Role of Cytokine Gene Score in Risk Prediction of Premature Coronary Artery Disease
Pro- and anti-inflammatory cytokines play a significant role in early atherosclerosis. Linkage disequilibrium patterns differ between ethnic groups pointing toward the need to develop population-specific gene risk scores. Our objective was to investigate the role of a cytokine gene score in the risk...
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| Veröffentlicht in: | Genetic testing and molecular biomarkers 2016-11, Vol.20 (11), p.685-691 |
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| creator | Omer, Wafa Naveed, Abdul K Khan, Omer J Khan, Dilshad A |
| description | Pro- and anti-inflammatory cytokines play a significant role in early atherosclerosis. Linkage disequilibrium patterns differ between ethnic groups pointing toward the need to develop population-specific gene risk scores. Our objective was to investigate the role of a cytokine gene score in the risk prediction of premature coronary artery disease (PCAD).
A case-control study was performed at the National University of Sciences and Technology (NUST) in collaboration with the Cardiovascular Genetics Institute, University College London, United Kingdom. Three hundred forty subjects with >70% stenosis in at least one coronary vessel on angiography were labeled as PCAD cases and compared with 310 angio-negative controls. Genotyping of the rs187238 (interleukin [IL]-18), rs1800795 (IL-6), rs1800629 (tumor necrosis factor [TNF]-alpha), rs1800871 (IL-10), and rs1946519 (IL-18) SNPs was performed using KASPar and TaqMan assays.
The odds ratio for cytokine gene score was significantly higher for PCAD (p = 0.025) when adjusted for age, sex, and ethnicity. There was a highly significant difference in gene risk allele frequency between Pakistanis and Caucasians (Northwick Park Heart Study II [NPHSII]) for rs187238 (IL-18), rs1800795 (IL-6), rs1800629 (TNF-alpha), and rs1800871 (IL-10) (p |
| doi_str_mv | 10.1089/gtmb.2016.0108 |
| format | Article |
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A case-control study was performed at the National University of Sciences and Technology (NUST) in collaboration with the Cardiovascular Genetics Institute, University College London, United Kingdom. Three hundred forty subjects with >70% stenosis in at least one coronary vessel on angiography were labeled as PCAD cases and compared with 310 angio-negative controls. Genotyping of the rs187238 (interleukin [IL]-18), rs1800795 (IL-6), rs1800629 (tumor necrosis factor [TNF]-alpha), rs1800871 (IL-10), and rs1946519 (IL-18) SNPs was performed using KASPar and TaqMan assays.
The odds ratio for cytokine gene score was significantly higher for PCAD (p = 0.025) when adjusted for age, sex, and ethnicity. There was a highly significant difference in gene risk allele frequency between Pakistanis and Caucasians (Northwick Park Heart Study II [NPHSII]) for rs187238 (IL-18), rs1800795 (IL-6), rs1800629 (TNF-alpha), and rs1800871 (IL-10) (p < 0.01).
A cytokine gene score has significant discriminatory ability and potential in the risk prediction of PCAD. Cytokine gene risk allele frequencies differ significantly between Pakistanis and Caucasians supporting the need to develop population-specific gene scores.</description><identifier>ISSN: 1945-0265</identifier><identifier>EISSN: 1945-0257</identifier><identifier>DOI: 10.1089/gtmb.2016.0108</identifier><identifier>PMID: 27689253</identifier><language>eng</language><publisher>United States: Mary Ann Liebert, Inc</publisher><subject>Adult ; Alleles ; Angiography ; Arteriosclerosis ; Atherosclerosis ; Atherosclerosis - genetics ; Atherosclerosis - metabolism ; Cardiovascular disease ; Case-Control Studies ; Control methods ; Coronary artery ; Coronary artery disease ; Coronary Artery Disease - genetics ; Coronary Artery Disease - metabolism ; Coronary vessels ; Cytokines ; Cytokines - genetics ; Cytokines - metabolism ; Disease control ; Ethnic Groups - genetics ; Female ; Gene Frequency ; Genetic Predisposition to Disease ; Genetic Testing - methods ; Genetics ; Genotyping ; Health risks ; Heart ; Heart diseases ; Humans ; Inflammation ; Interleukin 10 ; Interleukin 18 ; Interleukin 6 ; Interleukins ; Interleukins - genetics ; Interleukins - metabolism ; Linkage Disequilibrium ; Male ; Middle Aged ; Minority & ethnic groups ; Necrosis ; Odds Ratio ; Polymorphism, Single Nucleotide ; Population genetics ; Risk ; Risk Factors ; Single-nucleotide polymorphism ; Stenosis ; Tumor Necrosis Factor-alpha - genetics ; Tumor Necrosis Factor-alpha - metabolism ; Tumor necrosis factor-TNF ; Tumor necrosis factor-α</subject><ispartof>Genetic testing and molecular biomarkers, 2016-11, Vol.20 (11), p.685-691</ispartof><rights>Copyright Mary Ann Liebert, Inc. Nov 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-5ab700892227db443748c59e3807820f98a7e939feb66cef359a48c693f3eacf3</citedby><cites>FETCH-LOGICAL-c356t-5ab700892227db443748c59e3807820f98a7e939feb66cef359a48c693f3eacf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27689253$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Omer, Wafa</creatorcontrib><creatorcontrib>Naveed, Abdul K</creatorcontrib><creatorcontrib>Khan, Omer J</creatorcontrib><creatorcontrib>Khan, Dilshad A</creatorcontrib><title>Role of Cytokine Gene Score in Risk Prediction of Premature Coronary Artery Disease</title><title>Genetic testing and molecular biomarkers</title><addtitle>Genet Test Mol Biomarkers</addtitle><description>Pro- and anti-inflammatory cytokines play a significant role in early atherosclerosis. Linkage disequilibrium patterns differ between ethnic groups pointing toward the need to develop population-specific gene risk scores. Our objective was to investigate the role of a cytokine gene score in the risk prediction of premature coronary artery disease (PCAD).
A case-control study was performed at the National University of Sciences and Technology (NUST) in collaboration with the Cardiovascular Genetics Institute, University College London, United Kingdom. Three hundred forty subjects with >70% stenosis in at least one coronary vessel on angiography were labeled as PCAD cases and compared with 310 angio-negative controls. Genotyping of the rs187238 (interleukin [IL]-18), rs1800795 (IL-6), rs1800629 (tumor necrosis factor [TNF]-alpha), rs1800871 (IL-10), and rs1946519 (IL-18) SNPs was performed using KASPar and TaqMan assays.
The odds ratio for cytokine gene score was significantly higher for PCAD (p = 0.025) when adjusted for age, sex, and ethnicity. There was a highly significant difference in gene risk allele frequency between Pakistanis and Caucasians (Northwick Park Heart Study II [NPHSII]) for rs187238 (IL-18), rs1800795 (IL-6), rs1800629 (TNF-alpha), and rs1800871 (IL-10) (p < 0.01).
A cytokine gene score has significant discriminatory ability and potential in the risk prediction of PCAD. Cytokine gene risk allele frequencies differ significantly between Pakistanis and Caucasians supporting the need to develop population-specific gene scores.</description><subject>Adult</subject><subject>Alleles</subject><subject>Angiography</subject><subject>Arteriosclerosis</subject><subject>Atherosclerosis</subject><subject>Atherosclerosis - genetics</subject><subject>Atherosclerosis - metabolism</subject><subject>Cardiovascular disease</subject><subject>Case-Control Studies</subject><subject>Control methods</subject><subject>Coronary artery</subject><subject>Coronary artery disease</subject><subject>Coronary Artery Disease - genetics</subject><subject>Coronary Artery Disease - metabolism</subject><subject>Coronary vessels</subject><subject>Cytokines</subject><subject>Cytokines - genetics</subject><subject>Cytokines - metabolism</subject><subject>Disease control</subject><subject>Ethnic Groups - genetics</subject><subject>Female</subject><subject>Gene Frequency</subject><subject>Genetic Predisposition to Disease</subject><subject>Genetic Testing - methods</subject><subject>Genetics</subject><subject>Genotyping</subject><subject>Health risks</subject><subject>Heart</subject><subject>Heart diseases</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Interleukin 10</subject><subject>Interleukin 18</subject><subject>Interleukin 6</subject><subject>Interleukins</subject><subject>Interleukins - genetics</subject><subject>Interleukins - metabolism</subject><subject>Linkage Disequilibrium</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Minority & ethnic groups</subject><subject>Necrosis</subject><subject>Odds Ratio</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Population genetics</subject><subject>Risk</subject><subject>Risk Factors</subject><subject>Single-nucleotide polymorphism</subject><subject>Stenosis</subject><subject>Tumor Necrosis Factor-alpha - genetics</subject><subject>Tumor Necrosis Factor-alpha - metabolism</subject><subject>Tumor necrosis factor-TNF</subject><subject>Tumor necrosis factor-α</subject><issn>1945-0265</issn><issn>1945-0257</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkT1PwzAQQC0EolBYGVEkFpYEf8Wxx6pAQaoEamG2nPSC0iZxsZOh_x5HLR2YWHw--fl0dw-hG4ITgqV6-OqaPKGYiASH_ARdEMXTGNM0Oz3eRTpCl96vMRacSXGORjQTUtGUXaDlwtYQ2TKa7jq7qVqIZhCOZWEdRFUbLSq_id4drKqiq2w7kCFrTNeH96l1tjVuF01cByE8Vh6Mhyt0Vpraw_UhjtHn89PH9CWev81ep5N5XLBUdHFq8gyHGSil2SrnnGVcFqkCJnEmKS6VNBkopkrIhSigZKkygRCKlQxMUbIxut_X3Tr73YPvdFP5AuratGB7r4nkgofdMPYPlClCFMEDevcHXdvetWEQTUloXCnOs0Ale6pw1nsHpd66qgm70ATrwYwezOjBjB7MhA-3h7J93sDqiP-qYD-mxYeY</recordid><startdate>201611</startdate><enddate>201611</enddate><creator>Omer, Wafa</creator><creator>Naveed, Abdul K</creator><creator>Khan, Omer J</creator><creator>Khan, Dilshad A</creator><general>Mary Ann Liebert, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7QP</scope><scope>7T5</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>201611</creationdate><title>Role of Cytokine Gene Score in Risk Prediction of Premature Coronary Artery Disease</title><author>Omer, Wafa ; Naveed, Abdul K ; Khan, Omer J ; Khan, Dilshad A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-5ab700892227db443748c59e3807820f98a7e939feb66cef359a48c693f3eacf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Alleles</topic><topic>Angiography</topic><topic>Arteriosclerosis</topic><topic>Atherosclerosis</topic><topic>Atherosclerosis - genetics</topic><topic>Atherosclerosis - metabolism</topic><topic>Cardiovascular disease</topic><topic>Case-Control Studies</topic><topic>Control methods</topic><topic>Coronary artery</topic><topic>Coronary artery disease</topic><topic>Coronary Artery Disease - genetics</topic><topic>Coronary Artery Disease - metabolism</topic><topic>Coronary vessels</topic><topic>Cytokines</topic><topic>Cytokines - genetics</topic><topic>Cytokines - metabolism</topic><topic>Disease control</topic><topic>Ethnic Groups - genetics</topic><topic>Female</topic><topic>Gene Frequency</topic><topic>Genetic Predisposition to Disease</topic><topic>Genetic Testing - methods</topic><topic>Genetics</topic><topic>Genotyping</topic><topic>Health risks</topic><topic>Heart</topic><topic>Heart diseases</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Interleukin 10</topic><topic>Interleukin 18</topic><topic>Interleukin 6</topic><topic>Interleukins</topic><topic>Interleukins - genetics</topic><topic>Interleukins - metabolism</topic><topic>Linkage Disequilibrium</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Minority & ethnic groups</topic><topic>Necrosis</topic><topic>Odds Ratio</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Population genetics</topic><topic>Risk</topic><topic>Risk Factors</topic><topic>Single-nucleotide polymorphism</topic><topic>Stenosis</topic><topic>Tumor Necrosis Factor-alpha - genetics</topic><topic>Tumor Necrosis Factor-alpha - metabolism</topic><topic>Tumor necrosis factor-TNF</topic><topic>Tumor necrosis factor-α</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Omer, Wafa</creatorcontrib><creatorcontrib>Naveed, Abdul K</creatorcontrib><creatorcontrib>Khan, Omer J</creatorcontrib><creatorcontrib>Khan, Dilshad A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Genetic testing and molecular biomarkers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Omer, Wafa</au><au>Naveed, Abdul K</au><au>Khan, Omer J</au><au>Khan, Dilshad A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of Cytokine Gene Score in Risk Prediction of Premature Coronary Artery Disease</atitle><jtitle>Genetic testing and molecular biomarkers</jtitle><addtitle>Genet Test Mol Biomarkers</addtitle><date>2016-11</date><risdate>2016</risdate><volume>20</volume><issue>11</issue><spage>685</spage><epage>691</epage><pages>685-691</pages><issn>1945-0265</issn><eissn>1945-0257</eissn><abstract>Pro- and anti-inflammatory cytokines play a significant role in early atherosclerosis. Linkage disequilibrium patterns differ between ethnic groups pointing toward the need to develop population-specific gene risk scores. Our objective was to investigate the role of a cytokine gene score in the risk prediction of premature coronary artery disease (PCAD).
A case-control study was performed at the National University of Sciences and Technology (NUST) in collaboration with the Cardiovascular Genetics Institute, University College London, United Kingdom. Three hundred forty subjects with >70% stenosis in at least one coronary vessel on angiography were labeled as PCAD cases and compared with 310 angio-negative controls. Genotyping of the rs187238 (interleukin [IL]-18), rs1800795 (IL-6), rs1800629 (tumor necrosis factor [TNF]-alpha), rs1800871 (IL-10), and rs1946519 (IL-18) SNPs was performed using KASPar and TaqMan assays.
The odds ratio for cytokine gene score was significantly higher for PCAD (p = 0.025) when adjusted for age, sex, and ethnicity. There was a highly significant difference in gene risk allele frequency between Pakistanis and Caucasians (Northwick Park Heart Study II [NPHSII]) for rs187238 (IL-18), rs1800795 (IL-6), rs1800629 (TNF-alpha), and rs1800871 (IL-10) (p < 0.01).
A cytokine gene score has significant discriminatory ability and potential in the risk prediction of PCAD. Cytokine gene risk allele frequencies differ significantly between Pakistanis and Caucasians supporting the need to develop population-specific gene scores.</abstract><cop>United States</cop><pub>Mary Ann Liebert, Inc</pub><pmid>27689253</pmid><doi>10.1089/gtmb.2016.0108</doi><tpages>7</tpages></addata></record> |
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| subjects | Adult Alleles Angiography Arteriosclerosis Atherosclerosis Atherosclerosis - genetics Atherosclerosis - metabolism Cardiovascular disease Case-Control Studies Control methods Coronary artery Coronary artery disease Coronary Artery Disease - genetics Coronary Artery Disease - metabolism Coronary vessels Cytokines Cytokines - genetics Cytokines - metabolism Disease control Ethnic Groups - genetics Female Gene Frequency Genetic Predisposition to Disease Genetic Testing - methods Genetics Genotyping Health risks Heart Heart diseases Humans Inflammation Interleukin 10 Interleukin 18 Interleukin 6 Interleukins Interleukins - genetics Interleukins - metabolism Linkage Disequilibrium Male Middle Aged Minority & ethnic groups Necrosis Odds Ratio Polymorphism, Single Nucleotide Population genetics Risk Risk Factors Single-nucleotide polymorphism Stenosis Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - metabolism Tumor necrosis factor-TNF Tumor necrosis factor-α |
| title | Role of Cytokine Gene Score in Risk Prediction of Premature Coronary Artery Disease |
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