Cellular endocytic compartment localization of expressed canine CD1 molecules

•Recombinant canine CD1 molecules localized to different cellular compartments.•Canine CD1 isoforms showed similar endocytic localization as their human counterparts.•Canine CD1d showed an abnormal protein translation. CD1 molecules are glycoproteins present primarily on dendritic cells (DCs), which...

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Veröffentlicht in:	Veterinary immunology and immunopathology 2016-12, Vol.182, p.11-21
Hauptverfasser:	Schjaerff, Mette, Keller, Stefan M., Affolter, Verena K., Kristensen, Annemarie T., Moore, Peter F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Antigens, CD1 - genetics Antigens, CD1 - metabolism Canine CD1 intracellular localization Canine CD1 molecules Cell Compartmentation - immunology Confocal microscopy Cytoplasmic tail trafficking motif Dogs - genetics Dogs - immunology Endocytic compartments Endosomes - immunology Green Fluorescent Proteins - genetics Green Fluorescent Proteins - metabolism HEK293 Cells Humans Isoantigens - genetics Isoantigens - metabolism Lysosomes - immunology Microscopy, Confocal Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - immunology
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