Exposure to anesthetic gases among operating room personnel and risk of genotoxicity: A systematic review of the human biomonitoring studies
Abstract Background and objective Anesthetic gases have been used for a long time. Adverse effects of anesthetic gases to occupationally exposed people have been well documented in the literature. Due to low solubility, these gases are rapidly eliminated from the human body. Nevertheless, neurotoxic...
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| Veröffentlicht in: | Journal of clinical anesthesia 2016-12, Vol.35, p.326-331 |
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| description | Abstract Background and objective Anesthetic gases have been used for a long time. Adverse effects of anesthetic gases to occupationally exposed people have been well documented in the literature. Due to low solubility, these gases are rapidly eliminated from the human body. Nevertheless, neurotoxic, immunosuppressive, hepatotoxic and reproductive toxicological effects have been shown in many of the scientific works. However, there is no detailed systematic bio-monitoring review about genotoxicity risk among occupationally exposed people. We herein performed systematic review based on relevant studies. Methods This work reviews the published literature about the genotoxic effects of anesthetic gases among operating room personnel published between 1989 and September 2015. We performed a computerized search of articles on Pubmed, Scopus, Web of Science, and Google Scholar. Results Analyzed works have shown us that chromosomal aberration, sister chromatid exchanges, micronucleus and comet assays were the most frequently used genotoxicity end-points. In almost all data, occupational exposure to anesthetic gases has been associated with statistically significant increase in genotoxic damage among operating room personnel. Conclusion Health care workers are exposed to wide variety of agents including biological, physical and chemical factors. Among them anesthetic gases seems to be deserve special attentions since their genotoxic, mutagenic activities. In addition, chronic exposure to all anesthetic gases instead of alone induces cumulative genotoxic effects. |
| doi_str_mv | 10.1016/j.jclinane.2016.08.029 |
| format | Article |
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Adverse effects of anesthetic gases to occupationally exposed people have been well documented in the literature. Due to low solubility, these gases are rapidly eliminated from the human body. Nevertheless, neurotoxic, immunosuppressive, hepatotoxic and reproductive toxicological effects have been shown in many of the scientific works. However, there is no detailed systematic bio-monitoring review about genotoxicity risk among occupationally exposed people. We herein performed systematic review based on relevant studies. Methods This work reviews the published literature about the genotoxic effects of anesthetic gases among operating room personnel published between 1989 and September 2015. We performed a computerized search of articles on Pubmed, Scopus, Web of Science, and Google Scholar. Results Analyzed works have shown us that chromosomal aberration, sister chromatid exchanges, micronucleus and comet assays were the most frequently used genotoxicity end-points. In almost all data, occupational exposure to anesthetic gases has been associated with statistically significant increase in genotoxic damage among operating room personnel. Conclusion Health care workers are exposed to wide variety of agents including biological, physical and chemical factors. Among them anesthetic gases seems to be deserve special attentions since their genotoxic, mutagenic activities. In addition, chronic exposure to all anesthetic gases instead of alone induces cumulative genotoxic effects.</description><identifier>ISSN: 0952-8180</identifier><identifier>EISSN: 1873-4529</identifier><identifier>DOI: 10.1016/j.jclinane.2016.08.029</identifier><identifier>PMID: 27871551</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Anesthesia ; Anesthesia & Perioperative Care ; Anesthesiology ; Anesthetic gases ; Anesthetics, Inhalation - adverse effects ; Cancer risk ; Chromosome Aberrations - chemically induced ; Comet Assay ; Deoxyribonucleic acid ; DNA ; DNA damage ; DNA Damage - drug effects ; Environmental Monitoring ; Female employees ; Genotoxicity ; Health Personnel ; Hospitals ; Humans ; Infertility ; Lymphocytes ; Micronuclei, Chromosome-Defective - chemically induced ; Miscarriage ; Nitrous oxide ; Nurses ; Occupational Exposure - adverse effects ; Operating room personnel ; Operating Rooms ; Pain Medicine ; Risk ; Sister Chromatid Exchange - drug effects ; Studies ; Surgeons ; Systematic review ; Urine</subject><ispartof>Journal of clinical anesthesia, 2016-12, Vol.35, p.326-331</ispartof><rights>Elsevier Inc.</rights><rights>2016 Elsevier Inc.</rights><rights>Copyright © 2016 Elsevier Inc. All rights reserved.</rights><rights>Copyright Elsevier Limited Dec 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c484t-4a5b37757685594b0920a516bae75918f82ed45202767ffe899212bda57022d33</citedby><cites>FETCH-LOGICAL-c484t-4a5b37757685594b0920a516bae75918f82ed45202767ffe899212bda57022d33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1846842036?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995,64385,64387,64389,72469</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27871551$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yilmaz, Serkan</creatorcontrib><creatorcontrib>Calbayram, Nazan Cakirer</creatorcontrib><title>Exposure to anesthetic gases among operating room personnel and risk of genotoxicity: A systematic review of the human biomonitoring studies</title><title>Journal of clinical anesthesia</title><addtitle>J Clin Anesth</addtitle><description>Abstract Background and objective Anesthetic gases have been used for a long time. Adverse effects of anesthetic gases to occupationally exposed people have been well documented in the literature. Due to low solubility, these gases are rapidly eliminated from the human body. Nevertheless, neurotoxic, immunosuppressive, hepatotoxic and reproductive toxicological effects have been shown in many of the scientific works. However, there is no detailed systematic bio-monitoring review about genotoxicity risk among occupationally exposed people. We herein performed systematic review based on relevant studies. Methods This work reviews the published literature about the genotoxic effects of anesthetic gases among operating room personnel published between 1989 and September 2015. We performed a computerized search of articles on Pubmed, Scopus, Web of Science, and Google Scholar. Results Analyzed works have shown us that chromosomal aberration, sister chromatid exchanges, micronucleus and comet assays were the most frequently used genotoxicity end-points. In almost all data, occupational exposure to anesthetic gases has been associated with statistically significant increase in genotoxic damage among operating room personnel. Conclusion Health care workers are exposed to wide variety of agents including biological, physical and chemical factors. Among them anesthetic gases seems to be deserve special attentions since their genotoxic, mutagenic activities. In addition, chronic exposure to all anesthetic gases instead of alone induces cumulative genotoxic effects.</description><subject>Anesthesia</subject><subject>Anesthesia & Perioperative Care</subject><subject>Anesthesiology</subject><subject>Anesthetic gases</subject><subject>Anesthetics, Inhalation - adverse effects</subject><subject>Cancer risk</subject><subject>Chromosome Aberrations - chemically induced</subject><subject>Comet Assay</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA damage</subject><subject>DNA Damage - drug effects</subject><subject>Environmental Monitoring</subject><subject>Female employees</subject><subject>Genotoxicity</subject><subject>Health Personnel</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Infertility</subject><subject>Lymphocytes</subject><subject>Micronuclei, Chromosome-Defective - chemically induced</subject><subject>Miscarriage</subject><subject>Nitrous oxide</subject><subject>Nurses</subject><subject>Occupational Exposure - adverse effects</subject><subject>Operating room personnel</subject><subject>Operating Rooms</subject><subject>Pain Medicine</subject><subject>Risk</subject><subject>Sister Chromatid Exchange - drug effects</subject><subject>Studies</subject><subject>Surgeons</subject><subject>Systematic review</subject><subject>Urine</subject><issn>0952-8180</issn><issn>1873-4529</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFks-O1SAUh4nRONfRV5iQuHHTCrQU6sI4mYx_kklcqGtC6ekd7rTlyqE69x18aKl3RpPZuALCxwfn_CDkjLOSM9683pU7N_rZzlCKvC6ZLploH5EN16oqainax2TDWikKzTU7Ic8Qd4yxvMGfkhOhtOJS8g35dXm7D7hEoCnQbMN0Dck7urUISO0U5i0Ne4g2-TyLIUw0rzDMM4yZ72n0eEPDQLcwhxRuvfPp8IaeUzxggsmurgg_PPxcoSyn18tkZ9r5kN0-hbh6MS29B3xOngx2RHhxN56Sb-8vv158LK4-f_h0cX5VuFrXqait7CqlpGq0lG3dsVYwK3nTWVCy5XrQAvpcKROqUcMAum0FF11vpWJC9FV1Sl4dvfsYvi-5ZjN5dDCOuQFhQcN13dRcN4pl9OUDdBeWOOfX_aF0LVjVZKo5Ui4GxAiD2Uc_2XgwnJk1L7Mz93mZNS_DtMl55YNnd_qlm6D_e-w-oAy8OwKQ-5HbGA06D7OD3kdwyfTB__-Otw8UK-WdHW_gAPivHoPCMPNl_TXrp-FNxRTjovoNTLnAPA</recordid><startdate>20161201</startdate><enddate>20161201</enddate><creator>Yilmaz, Serkan</creator><creator>Calbayram, Nazan Cakirer</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7QO</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20161201</creationdate><title>Exposure to anesthetic gases among operating room personnel and risk of genotoxicity: A systematic review of the human biomonitoring studies</title><author>Yilmaz, Serkan ; Calbayram, Nazan Cakirer</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c484t-4a5b37757685594b0920a516bae75918f82ed45202767ffe899212bda57022d33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Anesthesia</topic><topic>Anesthesia & Perioperative Care</topic><topic>Anesthesiology</topic><topic>Anesthetic gases</topic><topic>Anesthetics, Inhalation - adverse effects</topic><topic>Cancer risk</topic><topic>Chromosome Aberrations - chemically induced</topic><topic>Comet Assay</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>DNA damage</topic><topic>DNA Damage - drug effects</topic><topic>Environmental Monitoring</topic><topic>Female employees</topic><topic>Genotoxicity</topic><topic>Health Personnel</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Infertility</topic><topic>Lymphocytes</topic><topic>Micronuclei, Chromosome-Defective - chemically induced</topic><topic>Miscarriage</topic><topic>Nitrous oxide</topic><topic>Nurses</topic><topic>Occupational Exposure - adverse effects</topic><topic>Operating room personnel</topic><topic>Operating Rooms</topic><topic>Pain Medicine</topic><topic>Risk</topic><topic>Sister Chromatid Exchange - drug effects</topic><topic>Studies</topic><topic>Surgeons</topic><topic>Systematic review</topic><topic>Urine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yilmaz, Serkan</creatorcontrib><creatorcontrib>Calbayram, Nazan Cakirer</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>Biotechnology Research Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Journal of clinical anesthesia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yilmaz, Serkan</au><au>Calbayram, Nazan Cakirer</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Exposure to anesthetic gases among operating room personnel and risk of genotoxicity: A systematic review of the human biomonitoring studies</atitle><jtitle>Journal of clinical anesthesia</jtitle><addtitle>J Clin Anesth</addtitle><date>2016-12-01</date><risdate>2016</risdate><volume>35</volume><spage>326</spage><epage>331</epage><pages>326-331</pages><issn>0952-8180</issn><eissn>1873-4529</eissn><abstract>Abstract Background and objective Anesthetic gases have been used for a long time. Adverse effects of anesthetic gases to occupationally exposed people have been well documented in the literature. Due to low solubility, these gases are rapidly eliminated from the human body. Nevertheless, neurotoxic, immunosuppressive, hepatotoxic and reproductive toxicological effects have been shown in many of the scientific works. However, there is no detailed systematic bio-monitoring review about genotoxicity risk among occupationally exposed people. We herein performed systematic review based on relevant studies. Methods This work reviews the published literature about the genotoxic effects of anesthetic gases among operating room personnel published between 1989 and September 2015. We performed a computerized search of articles on Pubmed, Scopus, Web of Science, and Google Scholar. Results Analyzed works have shown us that chromosomal aberration, sister chromatid exchanges, micronucleus and comet assays were the most frequently used genotoxicity end-points. In almost all data, occupational exposure to anesthetic gases has been associated with statistically significant increase in genotoxic damage among operating room personnel. Conclusion Health care workers are exposed to wide variety of agents including biological, physical and chemical factors. Among them anesthetic gases seems to be deserve special attentions since their genotoxic, mutagenic activities. In addition, chronic exposure to all anesthetic gases instead of alone induces cumulative genotoxic effects.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>27871551</pmid><doi>10.1016/j.jclinane.2016.08.029</doi><tpages>6</tpages></addata></record> |
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| subjects | Anesthesia Anesthesia & Perioperative Care Anesthesiology Anesthetic gases Anesthetics, Inhalation - adverse effects Cancer risk Chromosome Aberrations - chemically induced Comet Assay Deoxyribonucleic acid DNA DNA damage DNA Damage - drug effects Environmental Monitoring Female employees Genotoxicity Health Personnel Hospitals Humans Infertility Lymphocytes Micronuclei, Chromosome-Defective - chemically induced Miscarriage Nitrous oxide Nurses Occupational Exposure - adverse effects Operating room personnel Operating Rooms Pain Medicine Risk Sister Chromatid Exchange - drug effects Studies Surgeons Systematic review Urine |
| title | Exposure to anesthetic gases among operating room personnel and risk of genotoxicity: A systematic review of the human biomonitoring studies |
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