Propofol-induced spike firing suppression is more pronounced in pyramidal neurons than in fast-spiking neurons in the rat insular cortex
Highlights • Propofol-induced modulation of electrophysiological properties were compared between pyramidal and GABAergic neurons. • Propofol hyperpolarized the resting membrane potential with a decrease in the input resistance in all cell subtypes. • Propofol also suppressed repetitive spike firing...
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| Veröffentlicht in: | Neuroscience 2016-12, Vol.339, p.548-560 |
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| creator | Kaneko, Keisuke Koyanagi, Yuko Oi, Yoshiyuki Kobayashi, Masayuki |
| description | Highlights • Propofol-induced modulation of electrophysiological properties were compared between pyramidal and GABAergic neurons. • Propofol hyperpolarized the resting membrane potential with a decrease in the input resistance in all cell subtypes. • Propofol also suppressed repetitive spike firing in all cell subtypes. • The degree of the propofol-induced changes in the membrane and firing properties was most potent in pyramidal neurons. • Potentiation of GABAA receptor-mediated tonic currents by propofol contributes to modulation of these membrane properties. |
| doi_str_mv | 10.1016/j.neuroscience.2016.10.016 |
| format | Article |
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| ispartof | Neuroscience, 2016-12, Vol.339, p.548-560 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Action Potentials - drug effects Action Potentials - physiology anesthetics Animals Cell Membrane - drug effects Cell Membrane - physiology Cerebral Cortex - cytology Cerebral Cortex - drug effects Cerebral Cortex - physiology Dose-Response Relationship, Drug Electric Impedance GABAergic GABAergic Neurons - drug effects GABAergic Neurons - physiology Hypnotics and Sedatives - pharmacology interneurons Interneurons - drug effects Interneurons - physiology Neurology nociception Patch-Clamp Techniques Propofol - pharmacology Pyramidal Cells - drug effects Pyramidal Cells - physiology Rats, Transgenic Receptors, GABA-A - metabolism Tissue Culture Techniques tonic current |
| title | Propofol-induced spike firing suppression is more pronounced in pyramidal neurons than in fast-spiking neurons in the rat insular cortex |
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