Development of nanotoxicology: implications for drug delivery and medical devices
Current nanotoxicology research suffers from suboptimal models, lack of correlations, variability within protocols, deficits in both material purity and physicochemical characterization. Reliable nanomaterial toxicity and mechanistic insights are required for health and toxicity risk assessments. Mu...
Gespeichert in:
| Veröffentlicht in: | Nanomedicine (London, England) England), 2015-07, Vol.10 (14), p.2289-2305 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2305 |
|---|---|
| container_issue | 14 |
| container_start_page | 2289 |
| container_title | Nanomedicine (London, England) |
| container_volume | 10 |
| creator | Bhattacharjee, Sourav Brayden, David J |
| description | Current nanotoxicology research suffers from suboptimal
models, lack of
correlations, variability within
protocols, deficits in both material purity and physicochemical characterization. Reliable nanomaterial toxicity and mechanistic insights are required for health and toxicity risk assessments. Much
toxicological data is inconclusive in designating whether nanomaterials for drug delivery and medical device implants are truly safe. A critique is presented to analyze the interface between toxicology and nanopharmaceuticals. Deficiencies of existing practices in toxicology are reviewed and useful emerging techniques (e.g., lab-on-a-chip, tissue engineering, atomic force microscopy, high-content analysis) are highlighted. Cross-fertilization between disciplines will aid development of biocompatible delivery and implant platforms while improvements are being suggested for better translation of nanotoxicology. |
| doi_str_mv | 10.2217/nnm.15.69 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_1846417289</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A423254825</galeid><sourcerecordid>A423254825</sourcerecordid><originalsourceid>FETCH-LOGICAL-c521t-67a8fc12ce38b3ed1ad18772e171a61573684e8901d7e8b2a968aebd8f77005c3</originalsourceid><addsrcrecordid>eNptkU1r3DAQhkVpaD7aQ_9AMfTSHLz1SJY07i2kX4FAKbRnoZXHi4ItbSV76f77aLNpCyWn-eDhnZl3GHsNzYpz0O9DmFYgV6p7xs5At1irTonnD7moJWJ3ys5zvmsaiRyaF-yUK4AWsTlj3z_Sjsa4nSjMVRyqYEOc42_v4hg3-w-Vn7ajd3b2MeRqiKnq07Kpehr9jtK-sqGvJuoLMZbmzjvKL9nJYMdMrx7jBfv5-dOP66_17bcvN9dXt7WTHOZaaYuDA-5I4FpQD7YH1JoTaLAKpBYKW8KugV4TrrntFFpa9zhoXQ5x4oK9O-puU_y1UJ7N5LOjcbSB4pINYKta0By7gr79D72LSwplO8NbwVFI0eh_1MaOZHwY4pysO4iaq5YLLlvkslCXR8qlmHOiwWyTn2zaG2jM4RumfMOANOow983j3GVdXPpL_rG_APIIDMu8JMrOU3BkjtWDrz7QE8L3GASWog</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2432835307</pqid></control><display><type>article</type><title>Development of nanotoxicology: implications for drug delivery and medical devices</title><source>MEDLINE</source><source>PubMed Central</source><creator>Bhattacharjee, Sourav ; Brayden, David J</creator><creatorcontrib>Bhattacharjee, Sourav ; Brayden, David J</creatorcontrib><description>Current nanotoxicology research suffers from suboptimal
models, lack of
correlations, variability within
protocols, deficits in both material purity and physicochemical characterization. Reliable nanomaterial toxicity and mechanistic insights are required for health and toxicity risk assessments. Much
toxicological data is inconclusive in designating whether nanomaterials for drug delivery and medical device implants are truly safe. A critique is presented to analyze the interface between toxicology and nanopharmaceuticals. Deficiencies of existing practices in toxicology are reviewed and useful emerging techniques (e.g., lab-on-a-chip, tissue engineering, atomic force microscopy, high-content analysis) are highlighted. Cross-fertilization between disciplines will aid development of biocompatible delivery and implant platforms while improvements are being suggested for better translation of nanotoxicology.</description><identifier>ISSN: 1743-5889</identifier><identifier>EISSN: 1748-6963</identifier><identifier>DOI: 10.2217/nnm.15.69</identifier><identifier>PMID: 26114880</identifier><language>eng</language><publisher>England: Future Medicine Ltd</publisher><subject>Adsorption ; biomaterials ; Content analysis ; Cytotoxicity ; Drug delivery systems ; Drug Delivery Systems - adverse effects ; Health aspects ; high-content analysis ; Humans ; Immunoglobulins ; lab-on-a-chip ; Laboratories ; Medical equipment ; Nanomaterials ; Nanomedicine ; Nanostructures - adverse effects ; Nanotechnology - methods ; nanotoxicology ; NMR ; Nuclear magnetic resonance ; Particle size ; predictive toxicology ; Proteins ; Quantum dots ; Risk Assessment ; Scanning electron microscopy ; Solvents ; Surface chemistry ; Testing ; Tissue engineering ; Toxicology ; Toxicology - methods</subject><ispartof>Nanomedicine (London, England), 2015-07, Vol.10 (14), p.2289-2305</ispartof><rights>Future Medicine Ltd</rights><rights>COPYRIGHT 2015 Future Medicine Ltd.</rights><rights>Copyright Future Medicine Ltd Jul 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c521t-67a8fc12ce38b3ed1ad18772e171a61573684e8901d7e8b2a968aebd8f77005c3</citedby><cites>FETCH-LOGICAL-c521t-67a8fc12ce38b3ed1ad18772e171a61573684e8901d7e8b2a968aebd8f77005c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26114880$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bhattacharjee, Sourav</creatorcontrib><creatorcontrib>Brayden, David J</creatorcontrib><title>Development of nanotoxicology: implications for drug delivery and medical devices</title><title>Nanomedicine (London, England)</title><addtitle>Nanomedicine (Lond)</addtitle><description>Current nanotoxicology research suffers from suboptimal
models, lack of
correlations, variability within
protocols, deficits in both material purity and physicochemical characterization. Reliable nanomaterial toxicity and mechanistic insights are required for health and toxicity risk assessments. Much
toxicological data is inconclusive in designating whether nanomaterials for drug delivery and medical device implants are truly safe. A critique is presented to analyze the interface between toxicology and nanopharmaceuticals. Deficiencies of existing practices in toxicology are reviewed and useful emerging techniques (e.g., lab-on-a-chip, tissue engineering, atomic force microscopy, high-content analysis) are highlighted. Cross-fertilization between disciplines will aid development of biocompatible delivery and implant platforms while improvements are being suggested for better translation of nanotoxicology.</description><subject>Adsorption</subject><subject>biomaterials</subject><subject>Content analysis</subject><subject>Cytotoxicity</subject><subject>Drug delivery systems</subject><subject>Drug Delivery Systems - adverse effects</subject><subject>Health aspects</subject><subject>high-content analysis</subject><subject>Humans</subject><subject>Immunoglobulins</subject><subject>lab-on-a-chip</subject><subject>Laboratories</subject><subject>Medical equipment</subject><subject>Nanomaterials</subject><subject>Nanomedicine</subject><subject>Nanostructures - adverse effects</subject><subject>Nanotechnology - methods</subject><subject>nanotoxicology</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Particle size</subject><subject>predictive toxicology</subject><subject>Proteins</subject><subject>Quantum dots</subject><subject>Risk Assessment</subject><subject>Scanning electron microscopy</subject><subject>Solvents</subject><subject>Surface chemistry</subject><subject>Testing</subject><subject>Tissue engineering</subject><subject>Toxicology</subject><subject>Toxicology - methods</subject><issn>1743-5889</issn><issn>1748-6963</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNptkU1r3DAQhkVpaD7aQ_9AMfTSHLz1SJY07i2kX4FAKbRnoZXHi4ItbSV76f77aLNpCyWn-eDhnZl3GHsNzYpz0O9DmFYgV6p7xs5At1irTonnD7moJWJ3ys5zvmsaiRyaF-yUK4AWsTlj3z_Sjsa4nSjMVRyqYEOc42_v4hg3-w-Vn7ajd3b2MeRqiKnq07Kpehr9jtK-sqGvJuoLMZbmzjvKL9nJYMdMrx7jBfv5-dOP66_17bcvN9dXt7WTHOZaaYuDA-5I4FpQD7YH1JoTaLAKpBYKW8KugV4TrrntFFpa9zhoXQ5x4oK9O-puU_y1UJ7N5LOjcbSB4pINYKta0By7gr79D72LSwplO8NbwVFI0eh_1MaOZHwY4pysO4iaq5YLLlvkslCXR8qlmHOiwWyTn2zaG2jM4RumfMOANOow983j3GVdXPpL_rG_APIIDMu8JMrOU3BkjtWDrz7QE8L3GASWog</recordid><startdate>20150701</startdate><enddate>20150701</enddate><creator>Bhattacharjee, Sourav</creator><creator>Brayden, David J</creator><general>Future Medicine Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>EHMNL</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20150701</creationdate><title>Development of nanotoxicology: implications for drug delivery and medical devices</title><author>Bhattacharjee, Sourav ; Brayden, David J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c521t-67a8fc12ce38b3ed1ad18772e171a61573684e8901d7e8b2a968aebd8f77005c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adsorption</topic><topic>biomaterials</topic><topic>Content analysis</topic><topic>Cytotoxicity</topic><topic>Drug delivery systems</topic><topic>Drug Delivery Systems - adverse effects</topic><topic>Health aspects</topic><topic>high-content analysis</topic><topic>Humans</topic><topic>Immunoglobulins</topic><topic>lab-on-a-chip</topic><topic>Laboratories</topic><topic>Medical equipment</topic><topic>Nanomaterials</topic><topic>Nanomedicine</topic><topic>Nanostructures - adverse effects</topic><topic>Nanotechnology - methods</topic><topic>nanotoxicology</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Particle size</topic><topic>predictive toxicology</topic><topic>Proteins</topic><topic>Quantum dots</topic><topic>Risk Assessment</topic><topic>Scanning electron microscopy</topic><topic>Solvents</topic><topic>Surface chemistry</topic><topic>Testing</topic><topic>Tissue engineering</topic><topic>Toxicology</topic><topic>Toxicology - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bhattacharjee, Sourav</creatorcontrib><creatorcontrib>Brayden, David J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>UK & Ireland Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Nanomedicine (London, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bhattacharjee, Sourav</au><au>Brayden, David J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Development of nanotoxicology: implications for drug delivery and medical devices</atitle><jtitle>Nanomedicine (London, England)</jtitle><addtitle>Nanomedicine (Lond)</addtitle><date>2015-07-01</date><risdate>2015</risdate><volume>10</volume><issue>14</issue><spage>2289</spage><epage>2305</epage><pages>2289-2305</pages><issn>1743-5889</issn><eissn>1748-6963</eissn><abstract>Current nanotoxicology research suffers from suboptimal
models, lack of
correlations, variability within
protocols, deficits in both material purity and physicochemical characterization. Reliable nanomaterial toxicity and mechanistic insights are required for health and toxicity risk assessments. Much
toxicological data is inconclusive in designating whether nanomaterials for drug delivery and medical device implants are truly safe. A critique is presented to analyze the interface between toxicology and nanopharmaceuticals. Deficiencies of existing practices in toxicology are reviewed and useful emerging techniques (e.g., lab-on-a-chip, tissue engineering, atomic force microscopy, high-content analysis) are highlighted. Cross-fertilization between disciplines will aid development of biocompatible delivery and implant platforms while improvements are being suggested for better translation of nanotoxicology.</abstract><cop>England</cop><pub>Future Medicine Ltd</pub><pmid>26114880</pmid><doi>10.2217/nnm.15.69</doi><tpages>17</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1743-5889 |
| ispartof | Nanomedicine (London, England), 2015-07, Vol.10 (14), p.2289-2305 |
| issn | 1743-5889 1748-6963 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1846417289 |
| source | MEDLINE; PubMed Central |
| subjects | Adsorption biomaterials Content analysis Cytotoxicity Drug delivery systems Drug Delivery Systems - adverse effects Health aspects high-content analysis Humans Immunoglobulins lab-on-a-chip Laboratories Medical equipment Nanomaterials Nanomedicine Nanostructures - adverse effects Nanotechnology - methods nanotoxicology NMR Nuclear magnetic resonance Particle size predictive toxicology Proteins Quantum dots Risk Assessment Scanning electron microscopy Solvents Surface chemistry Testing Tissue engineering Toxicology Toxicology - methods |
| title | Development of nanotoxicology: implications for drug delivery and medical devices |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-21T21%3A38%3A07IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Development%20of%20nanotoxicology:%20implications%20for%20drug%20delivery%20and%20medical%20devices&rft.jtitle=Nanomedicine%20(London,%20England)&rft.au=Bhattacharjee,%20Sourav&rft.date=2015-07-01&rft.volume=10&rft.issue=14&rft.spage=2289&rft.epage=2305&rft.pages=2289-2305&rft.issn=1743-5889&rft.eissn=1748-6963&rft_id=info:doi/10.2217/nnm.15.69&rft_dat=%3Cgale_proqu%3EA423254825%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2432835307&rft_id=info:pmid/26114880&rft_galeid=A423254825&rfr_iscdi=true |