Antagonism of picrotoxin-induced changes in dopamine and serotonin metabolism by allopregnanolone and midazolam

The effects of allopregnanolone and midazolam, given intracerebroventricularly, on the behavioral and biochemical effects of picrotoxin, were examined in a model of neurotoxin-induced seizures, in mice. After acute injections, midazolam (ED 50=39.8 nmol) and allopregnanolone (ED 50=11.0 nmol) produc...

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Veröffentlicht in:	Pharmacology, biochemistry and behavior biochemistry and behavior, 2002-07, Vol.72 (4), p.987-991
Hauptverfasser:	Maciejak, Piotr, Krząścik, Paweł, Członkowska, Agnieszka I., Szyndler, Janusz, Bidziński, Andrzej, Walkowiak, Jerzy, Kostowski, Wojciech, Plaznik, Adam
Format:	Artikel
Sprache:	eng
Schlagworte:	Allopregnanolone Amino Acids - metabolism Animals Anticonvulsants. Antiepileptics. Antiparkinson agents Biological and medical sciences Convulsants - pharmacology Dopamine Dopamine - metabolism Dose-Response Relationship, Drug GABA Antagonists - pharmacology GABA Modulators - pharmacology Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Injections, Intraventricular Intracerebroventricular injections Intraperitoneal injections Male Medical sciences Mice Microinjections Midazolam Midazolam - pharmacology Nervous system (semeiology, syndromes) Neurology Neuropharmacology Pharmacology. Drug treatments Picrotoxin Picrotoxin - antagonists & inhibitors Picrotoxin - pharmacology Pregnanolone - pharmacology Seizures Seizures - chemically induced Seizures - psychology Serotonin Serotonin - metabolism
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