Missed Opportunities for Loco-Regional Treatment of Elderly Women with Breast Cancer
Background Factors associated with surgery, adjuvant radiotherapy, and chemotherapy and whether there were missed opportunities for treatment in elderly patients were determined in an Asian setting. Methods All 5616 patients, diagnosed with breast cancer in University Malaya Medical Centre from 1999...
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| Veröffentlicht in: | World journal of surgery 2016-12, Vol.40 (12), p.2913-2921 |
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| creator | Bhoo-Pathy, Nirmala Balakrishnan, Nanthini See, Mee-Hoong Taib, Nur Aishah Yip, Cheng-Har |
| description | Background
Factors associated with surgery, adjuvant radiotherapy, and chemotherapy and whether there were missed opportunities for treatment in elderly patients were determined in an Asian setting.
Methods
All 5616 patients, diagnosed with breast cancer in University Malaya Medical Centre from 1999 to 2013 were included. In 945 elderly patients (aged 65 years and above), multivariable logistic regression was performed to identify factors associated with treatment, following adjustment for age, ethnicity, tumor, and other treatment characteristics. The impact of lack of treatment on survival of the elderly was assessed while accounting for comorbidities.
Results
One in five elderly patients had comorbidities. Compared to younger patients, the elderly had more favorable tumor characteristics, and received less loco-regional treatment and chemotherapy. Within stage I–IIIa elderly breast cancer patients, 10 % did not receive any surgery. These patients were older, more likely to be Malays, have comorbidities, and bigger tumors. In elderlies with indications for adjuvant radiotherapy, no irradiation (30 %) was associated with increasing age, comorbidity, and the absence of systemic therapy. Hormone therapy was optimal, but only 35 % of elderly women with ER negative tumors received chemotherapy. Compared to elderly women who received adequate treatment, those not receiving surgery (adjusted hazard ratio: 2.30, 95 %CI: 1.10–4.79), or radiotherapy (adjusted hazard ratio: 1.56, 95 %CI: 1.10–2.19), were associated with higher mortality. Less than 25 % of the survival discrepancy between elderly women receiving loco-regional treatment and no treatment were attributed to excess comorbidities in untreated patients.
Conclusion
While the presence of comorbidities significantly influenced loco-regional treatment decisions in the elderly, it was only able to explain the lower survival rates in untreated patients up to a certain extent, suggesting missed opportunities for treatment. |
| doi_str_mv | 10.1007/s00268-016-3658-z |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1846416113</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>4245514471</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4072-d4545fd34db95e3eb73abd45f05c6a308ff1bc83b933c8486a5e0562d6662af83</originalsourceid><addsrcrecordid>eNqNkV-L1DAUxYMo7jj6AXyRgC--VG_-NEkf3WHXXRlZ0JF9DGl7s3bpNGPSssx-elO6igiiTwn3_s7lcA4hLxm8ZQD6XQLgyhTAVCFUaYr7R2TFpOAFF1w8JisQSuY_EyfkWUq3AEwrUE_JCdeyVLLSK7L71KWELb06HEIcp6EbO0zUh0i3oQnFZ7zpwuB6uovoxj0OIw2envUtxv5Ir0Oe0Ltu_EZP8z6NdOOGBuNz8sS7PuGLh3dNvp6f7TYXxfbqw-Xm_bZoJGhetLKUpW-FbOuqRIG1Fq7OQw9lo5wA4z2rGyPqSojGSKNciVAq3iqluPNGrMmb5e4hhu8TptHuu9Rg37sBw5QsM1JJphgT_4Fypbmeg1uT13-gt2GKOYSZErqCHL3OFFuoJoaUInp7iN3exaNlYOd27NKOze3YuR17nzWvHi5P9R7bX4qfdWSgWoC7rsfjvy_a649fTs_BgJxt80Wbsmy4wfib7b86-gFajqp9</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1837900077</pqid></control><display><type>article</type><title>Missed Opportunities for Loco-Regional Treatment of Elderly Women with Breast Cancer</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><source>SpringerLink Journals - AutoHoldings</source><creator>Bhoo-Pathy, Nirmala ; Balakrishnan, Nanthini ; See, Mee-Hoong ; Taib, Nur Aishah ; Yip, Cheng-Har</creator><creatorcontrib>Bhoo-Pathy, Nirmala ; Balakrishnan, Nanthini ; See, Mee-Hoong ; Taib, Nur Aishah ; Yip, Cheng-Har</creatorcontrib><description>Background
Factors associated with surgery, adjuvant radiotherapy, and chemotherapy and whether there were missed opportunities for treatment in elderly patients were determined in an Asian setting.
Methods
All 5616 patients, diagnosed with breast cancer in University Malaya Medical Centre from 1999 to 2013 were included. In 945 elderly patients (aged 65 years and above), multivariable logistic regression was performed to identify factors associated with treatment, following adjustment for age, ethnicity, tumor, and other treatment characteristics. The impact of lack of treatment on survival of the elderly was assessed while accounting for comorbidities.
Results
One in five elderly patients had comorbidities. Compared to younger patients, the elderly had more favorable tumor characteristics, and received less loco-regional treatment and chemotherapy. Within stage I–IIIa elderly breast cancer patients, 10 % did not receive any surgery. These patients were older, more likely to be Malays, have comorbidities, and bigger tumors. In elderlies with indications for adjuvant radiotherapy, no irradiation (30 %) was associated with increasing age, comorbidity, and the absence of systemic therapy. Hormone therapy was optimal, but only 35 % of elderly women with ER negative tumors received chemotherapy. Compared to elderly women who received adequate treatment, those not receiving surgery (adjusted hazard ratio: 2.30, 95 %CI: 1.10–4.79), or radiotherapy (adjusted hazard ratio: 1.56, 95 %CI: 1.10–2.19), were associated with higher mortality. Less than 25 % of the survival discrepancy between elderly women receiving loco-regional treatment and no treatment were attributed to excess comorbidities in untreated patients.
Conclusion
While the presence of comorbidities significantly influenced loco-regional treatment decisions in the elderly, it was only able to explain the lower survival rates in untreated patients up to a certain extent, suggesting missed opportunities for treatment.</description><identifier>ISSN: 0364-2313</identifier><identifier>EISSN: 1432-2323</identifier><identifier>DOI: 10.1007/s00268-016-3658-z</identifier><identifier>PMID: 27456497</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Abdominal Surgery ; Adjuvant Radiotherapy ; Age Factors ; Aged ; Antineoplastic Agents, Hormonal - therapeutic use ; Breast Cancer ; Breast Neoplasms - ethnology ; Breast Neoplasms - pathology ; Breast Neoplasms - therapy ; Cardiac Surgery ; Chemotherapy, Adjuvant ; Comorbidity ; Elderly Woman ; Estrogen Receptor Negative Tumor ; Estrogen Receptor Positive Breast Cancer ; Female ; General Surgery ; Humans ; Logistic Models ; Malaysia ; Mastectomy, Segmental ; Medicine ; Medicine & Public Health ; Middle Aged ; Neoplasm Staging ; Original Scientific Report ; Proportional Hazards Models ; Radiotherapy, Adjuvant ; Surgery ; Survival Rate ; Thoracic Surgery ; Tumor Burden ; Vascular Surgery</subject><ispartof>World journal of surgery, 2016-12, Vol.40 (12), p.2913-2921</ispartof><rights>Société Internationale de Chirurgie 2016</rights><rights>2016 The Author(s) under exclusive licence to Société Internationale de Chirurgie</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c4072-d4545fd34db95e3eb73abd45f05c6a308ff1bc83b933c8486a5e0562d6662af83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00268-016-3658-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00268-016-3658-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,41488,42557,45574,45575,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27456497$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bhoo-Pathy, Nirmala</creatorcontrib><creatorcontrib>Balakrishnan, Nanthini</creatorcontrib><creatorcontrib>See, Mee-Hoong</creatorcontrib><creatorcontrib>Taib, Nur Aishah</creatorcontrib><creatorcontrib>Yip, Cheng-Har</creatorcontrib><title>Missed Opportunities for Loco-Regional Treatment of Elderly Women with Breast Cancer</title><title>World journal of surgery</title><addtitle>World J Surg</addtitle><addtitle>World J Surg</addtitle><description>Background
Factors associated with surgery, adjuvant radiotherapy, and chemotherapy and whether there were missed opportunities for treatment in elderly patients were determined in an Asian setting.
Methods
All 5616 patients, diagnosed with breast cancer in University Malaya Medical Centre from 1999 to 2013 were included. In 945 elderly patients (aged 65 years and above), multivariable logistic regression was performed to identify factors associated with treatment, following adjustment for age, ethnicity, tumor, and other treatment characteristics. The impact of lack of treatment on survival of the elderly was assessed while accounting for comorbidities.
Results
One in five elderly patients had comorbidities. Compared to younger patients, the elderly had more favorable tumor characteristics, and received less loco-regional treatment and chemotherapy. Within stage I–IIIa elderly breast cancer patients, 10 % did not receive any surgery. These patients were older, more likely to be Malays, have comorbidities, and bigger tumors. In elderlies with indications for adjuvant radiotherapy, no irradiation (30 %) was associated with increasing age, comorbidity, and the absence of systemic therapy. Hormone therapy was optimal, but only 35 % of elderly women with ER negative tumors received chemotherapy. Compared to elderly women who received adequate treatment, those not receiving surgery (adjusted hazard ratio: 2.30, 95 %CI: 1.10–4.79), or radiotherapy (adjusted hazard ratio: 1.56, 95 %CI: 1.10–2.19), were associated with higher mortality. Less than 25 % of the survival discrepancy between elderly women receiving loco-regional treatment and no treatment were attributed to excess comorbidities in untreated patients.
Conclusion
While the presence of comorbidities significantly influenced loco-regional treatment decisions in the elderly, it was only able to explain the lower survival rates in untreated patients up to a certain extent, suggesting missed opportunities for treatment.</description><subject>Abdominal Surgery</subject><subject>Adjuvant Radiotherapy</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Antineoplastic Agents, Hormonal - therapeutic use</subject><subject>Breast Cancer</subject><subject>Breast Neoplasms - ethnology</subject><subject>Breast Neoplasms - pathology</subject><subject>Breast Neoplasms - therapy</subject><subject>Cardiac Surgery</subject><subject>Chemotherapy, Adjuvant</subject><subject>Comorbidity</subject><subject>Elderly Woman</subject><subject>Estrogen Receptor Negative Tumor</subject><subject>Estrogen Receptor Positive Breast Cancer</subject><subject>Female</subject><subject>General Surgery</subject><subject>Humans</subject><subject>Logistic Models</subject><subject>Malaysia</subject><subject>Mastectomy, Segmental</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Neoplasm Staging</subject><subject>Original Scientific Report</subject><subject>Proportional Hazards Models</subject><subject>Radiotherapy, Adjuvant</subject><subject>Surgery</subject><subject>Survival Rate</subject><subject>Thoracic Surgery</subject><subject>Tumor Burden</subject><subject>Vascular Surgery</subject><issn>0364-2313</issn><issn>1432-2323</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqNkV-L1DAUxYMo7jj6AXyRgC--VG_-NEkf3WHXXRlZ0JF9DGl7s3bpNGPSssx-elO6igiiTwn3_s7lcA4hLxm8ZQD6XQLgyhTAVCFUaYr7R2TFpOAFF1w8JisQSuY_EyfkWUq3AEwrUE_JCdeyVLLSK7L71KWELb06HEIcp6EbO0zUh0i3oQnFZ7zpwuB6uovoxj0OIw2envUtxv5Ir0Oe0Ltu_EZP8z6NdOOGBuNz8sS7PuGLh3dNvp6f7TYXxfbqw-Xm_bZoJGhetLKUpW-FbOuqRIG1Fq7OQw9lo5wA4z2rGyPqSojGSKNciVAq3iqluPNGrMmb5e4hhu8TptHuu9Rg37sBw5QsM1JJphgT_4Fypbmeg1uT13-gt2GKOYSZErqCHL3OFFuoJoaUInp7iN3exaNlYOd27NKOze3YuR17nzWvHi5P9R7bX4qfdWSgWoC7rsfjvy_a649fTs_BgJxt80Wbsmy4wfib7b86-gFajqp9</recordid><startdate>201612</startdate><enddate>201612</enddate><creator>Bhoo-Pathy, Nirmala</creator><creator>Balakrishnan, Nanthini</creator><creator>See, Mee-Hoong</creator><creator>Taib, Nur Aishah</creator><creator>Yip, Cheng-Har</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>201612</creationdate><title>Missed Opportunities for Loco-Regional Treatment of Elderly Women with Breast Cancer</title><author>Bhoo-Pathy, Nirmala ; Balakrishnan, Nanthini ; See, Mee-Hoong ; Taib, Nur Aishah ; Yip, Cheng-Har</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4072-d4545fd34db95e3eb73abd45f05c6a308ff1bc83b933c8486a5e0562d6662af83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Abdominal Surgery</topic><topic>Adjuvant Radiotherapy</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Antineoplastic Agents, Hormonal - therapeutic use</topic><topic>Breast Cancer</topic><topic>Breast Neoplasms - ethnology</topic><topic>Breast Neoplasms - pathology</topic><topic>Breast Neoplasms - therapy</topic><topic>Cardiac Surgery</topic><topic>Chemotherapy, Adjuvant</topic><topic>Comorbidity</topic><topic>Elderly Woman</topic><topic>Estrogen Receptor Negative Tumor</topic><topic>Estrogen Receptor Positive Breast Cancer</topic><topic>Female</topic><topic>General Surgery</topic><topic>Humans</topic><topic>Logistic Models</topic><topic>Malaysia</topic><topic>Mastectomy, Segmental</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Neoplasm Staging</topic><topic>Original Scientific Report</topic><topic>Proportional Hazards Models</topic><topic>Radiotherapy, Adjuvant</topic><topic>Surgery</topic><topic>Survival Rate</topic><topic>Thoracic Surgery</topic><topic>Tumor Burden</topic><topic>Vascular Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bhoo-Pathy, Nirmala</creatorcontrib><creatorcontrib>Balakrishnan, Nanthini</creatorcontrib><creatorcontrib>See, Mee-Hoong</creatorcontrib><creatorcontrib>Taib, Nur Aishah</creatorcontrib><creatorcontrib>Yip, Cheng-Har</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>World journal of surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bhoo-Pathy, Nirmala</au><au>Balakrishnan, Nanthini</au><au>See, Mee-Hoong</au><au>Taib, Nur Aishah</au><au>Yip, Cheng-Har</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Missed Opportunities for Loco-Regional Treatment of Elderly Women with Breast Cancer</atitle><jtitle>World journal of surgery</jtitle><stitle>World J Surg</stitle><addtitle>World J Surg</addtitle><date>2016-12</date><risdate>2016</risdate><volume>40</volume><issue>12</issue><spage>2913</spage><epage>2921</epage><pages>2913-2921</pages><issn>0364-2313</issn><eissn>1432-2323</eissn><abstract>Background
Factors associated with surgery, adjuvant radiotherapy, and chemotherapy and whether there were missed opportunities for treatment in elderly patients were determined in an Asian setting.
Methods
All 5616 patients, diagnosed with breast cancer in University Malaya Medical Centre from 1999 to 2013 were included. In 945 elderly patients (aged 65 years and above), multivariable logistic regression was performed to identify factors associated with treatment, following adjustment for age, ethnicity, tumor, and other treatment characteristics. The impact of lack of treatment on survival of the elderly was assessed while accounting for comorbidities.
Results
One in five elderly patients had comorbidities. Compared to younger patients, the elderly had more favorable tumor characteristics, and received less loco-regional treatment and chemotherapy. Within stage I–IIIa elderly breast cancer patients, 10 % did not receive any surgery. These patients were older, more likely to be Malays, have comorbidities, and bigger tumors. In elderlies with indications for adjuvant radiotherapy, no irradiation (30 %) was associated with increasing age, comorbidity, and the absence of systemic therapy. Hormone therapy was optimal, but only 35 % of elderly women with ER negative tumors received chemotherapy. Compared to elderly women who received adequate treatment, those not receiving surgery (adjusted hazard ratio: 2.30, 95 %CI: 1.10–4.79), or radiotherapy (adjusted hazard ratio: 1.56, 95 %CI: 1.10–2.19), were associated with higher mortality. Less than 25 % of the survival discrepancy between elderly women receiving loco-regional treatment and no treatment were attributed to excess comorbidities in untreated patients.
Conclusion
While the presence of comorbidities significantly influenced loco-regional treatment decisions in the elderly, it was only able to explain the lower survival rates in untreated patients up to a certain extent, suggesting missed opportunities for treatment.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>27456497</pmid><doi>10.1007/s00268-016-3658-z</doi><tpages>9</tpages></addata></record> |
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| subjects | Abdominal Surgery Adjuvant Radiotherapy Age Factors Aged Antineoplastic Agents, Hormonal - therapeutic use Breast Cancer Breast Neoplasms - ethnology Breast Neoplasms - pathology Breast Neoplasms - therapy Cardiac Surgery Chemotherapy, Adjuvant Comorbidity Elderly Woman Estrogen Receptor Negative Tumor Estrogen Receptor Positive Breast Cancer Female General Surgery Humans Logistic Models Malaysia Mastectomy, Segmental Medicine Medicine & Public Health Middle Aged Neoplasm Staging Original Scientific Report Proportional Hazards Models Radiotherapy, Adjuvant Surgery Survival Rate Thoracic Surgery Tumor Burden Vascular Surgery |
| title | Missed Opportunities for Loco-Regional Treatment of Elderly Women with Breast Cancer |
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