Cytotoxicity and genotoxicity induced by coal and coal fly ash particles samples in V79 cells
Exposure to coal and coal ashes can cause harmful effects in in vitro and in vivo systems, mainly by the induction of oxidative damage. The aim of this work was to assess cytotoxic and genotoxic effects using the V79 cell line treated with coal and coal fly ash particles derived from a coal power pl...
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| Veröffentlicht in: | Environmental science and pollution research international 2016-12, Vol.23 (23), p.24019-24031 |
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| creator | León-Mejía, Grethel Silva, Luis F. O. Civeira, Matheus S. Oliveira, Marcos L. S. Machado, Miriana Villela, Izabel Vianna Hartmann, Andreas Premoli, Suziane Corrêa, Dione Silva Da Silva, Juliana Henriques, João Antônio Pêgas |
| description | Exposure to coal and coal ashes can cause harmful effects in in vitro and in vivo systems, mainly by the induction of oxidative damage. The aim of this work was to assess cytotoxic and genotoxic effects using the V79 cell line treated with coal and coal fly ash particles derived from a coal power plant located in Santa Catarina, Brazil. Two coal samples (COAL11 and COAL16) and two coal fly ash samples (CFA11 and CFA16) were included in this study. COAL16 was co-firing with a mixture of fuel oil and diesel oil. The comet assay data showed that exposure of V79 cells to coal and coal fly ash particles induced primary DNA lesions. Application of lesion-specific endonucleases (FPG and ENDO III) demonstrated increased DNA effects indicating the presence of high amounts of oxidative DNA lesions. The cytokinesis-block micronucleus cytome assay analysis showed that exposure of V79 cells to high concentrations of coal and coal fly ash particles induced cytotoxic effects (apoptosis and necrosis) and chromosomal instability (nucleoplasmic bridges, nuclear buds, and micronucleus (MN) formation). These results may be associated with compounds contained in the surface of the particles as hazardous elements, ultrafine/nanoparticles, and polycyclic aromatic hydrocarbons (PAHs) which were detected in the samples.
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| doi_str_mv | 10.1007/s11356-016-7623-z |
| format | Article |
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Graphical abstract
ᅟ</description><identifier>ISSN: 0944-1344</identifier><identifier>EISSN: 1614-7499</identifier><identifier>DOI: 10.1007/s11356-016-7623-z</identifier><identifier>PMID: 27638803</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Aquatic Pollution ; Atmospheric Protection/Air Quality Control/Air Pollution ; Bioassays ; Brazil ; Cell Line ; Coal ; Coal - analysis ; Coal - toxicity ; Coal Ash - analysis ; Coal Ash - toxicity ; Coal mining ; Coal-fired power plants ; Comet Assay ; Cytotoxicity ; Deoxyribonucleic acid ; DNA ; DNA Damage ; Earth and Environmental Science ; Ecotoxicology ; Electrons ; Environment ; Environmental Chemistry ; Environmental Health ; Environmental impact ; Environmental science ; Fly ash ; Genotoxicity ; Humans ; Lesions ; Nanoparticles - analysis ; Nanoparticles - toxicity ; Polycyclic aromatic hydrocarbons ; Polycyclic Aromatic Hydrocarbons - analysis ; Polycyclic Aromatic Hydrocarbons - toxicity ; Power Plants ; Research Article ; Scientific imaging ; Studies ; Waste Water Technology ; Water Management ; Water Pollution Control</subject><ispartof>Environmental science and pollution research international, 2016-12, Vol.23 (23), p.24019-24031</ispartof><rights>Springer-Verlag Berlin Heidelberg 2016</rights><rights>Environmental Science and Pollution Research is a copyright of Springer, 2016.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c489t-a1d07cb90dfa7217ded974fd3d8fd07baab6930fe3463e943cfcd292b0d9cc263</citedby><cites>FETCH-LOGICAL-c489t-a1d07cb90dfa7217ded974fd3d8fd07baab6930fe3463e943cfcd292b0d9cc263</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11356-016-7623-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11356-016-7623-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,782,786,27933,27934,41497,42566,51328</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27638803$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>León-Mejía, Grethel</creatorcontrib><creatorcontrib>Silva, Luis F. O.</creatorcontrib><creatorcontrib>Civeira, Matheus S.</creatorcontrib><creatorcontrib>Oliveira, Marcos L. S.</creatorcontrib><creatorcontrib>Machado, Miriana</creatorcontrib><creatorcontrib>Villela, Izabel Vianna</creatorcontrib><creatorcontrib>Hartmann, Andreas</creatorcontrib><creatorcontrib>Premoli, Suziane</creatorcontrib><creatorcontrib>Corrêa, Dione Silva</creatorcontrib><creatorcontrib>Da Silva, Juliana</creatorcontrib><creatorcontrib>Henriques, João Antônio Pêgas</creatorcontrib><title>Cytotoxicity and genotoxicity induced by coal and coal fly ash particles samples in V79 cells</title><title>Environmental science and pollution research international</title><addtitle>Environ Sci Pollut Res</addtitle><addtitle>Environ Sci Pollut Res Int</addtitle><description>Exposure to coal and coal ashes can cause harmful effects in in vitro and in vivo systems, mainly by the induction of oxidative damage. The aim of this work was to assess cytotoxic and genotoxic effects using the V79 cell line treated with coal and coal fly ash particles derived from a coal power plant located in Santa Catarina, Brazil. Two coal samples (COAL11 and COAL16) and two coal fly ash samples (CFA11 and CFA16) were included in this study. COAL16 was co-firing with a mixture of fuel oil and diesel oil. The comet assay data showed that exposure of V79 cells to coal and coal fly ash particles induced primary DNA lesions. Application of lesion-specific endonucleases (FPG and ENDO III) demonstrated increased DNA effects indicating the presence of high amounts of oxidative DNA lesions. The cytokinesis-block micronucleus cytome assay analysis showed that exposure of V79 cells to high concentrations of coal and coal fly ash particles induced cytotoxic effects (apoptosis and necrosis) and chromosomal instability (nucleoplasmic bridges, nuclear buds, and micronucleus (MN) formation). These results may be associated with compounds contained in the surface of the particles as hazardous elements, ultrafine/nanoparticles, and polycyclic aromatic hydrocarbons (PAHs) which were detected in the samples.
Graphical abstract
ᅟ</description><subject>Aquatic Pollution</subject><subject>Atmospheric Protection/Air Quality Control/Air Pollution</subject><subject>Bioassays</subject><subject>Brazil</subject><subject>Cell Line</subject><subject>Coal</subject><subject>Coal - analysis</subject><subject>Coal - toxicity</subject><subject>Coal Ash - analysis</subject><subject>Coal Ash - toxicity</subject><subject>Coal mining</subject><subject>Coal-fired power plants</subject><subject>Comet Assay</subject><subject>Cytotoxicity</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA Damage</subject><subject>Earth and Environmental Science</subject><subject>Ecotoxicology</subject><subject>Electrons</subject><subject>Environment</subject><subject>Environmental Chemistry</subject><subject>Environmental Health</subject><subject>Environmental impact</subject><subject>Environmental science</subject><subject>Fly ash</subject><subject>Genotoxicity</subject><subject>Humans</subject><subject>Lesions</subject><subject>Nanoparticles - analysis</subject><subject>Nanoparticles - toxicity</subject><subject>Polycyclic aromatic hydrocarbons</subject><subject>Polycyclic Aromatic Hydrocarbons - analysis</subject><subject>Polycyclic Aromatic Hydrocarbons - toxicity</subject><subject>Power Plants</subject><subject>Research Article</subject><subject>Scientific imaging</subject><subject>Studies</subject><subject>Waste Water Technology</subject><subject>Water Management</subject><subject>Water Pollution Control</subject><issn>0944-1344</issn><issn>1614-7499</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kMtKxDAUhoMozjj6AG6k4MZNNLcmzVIGbzDgRt1JSJN07NDL2LRg5-lNp-MFwdUJOd_5z-ED4BSjS4yQuPIY05hDhDkUnFC42QNTzDGDgkm5D6ZIMgYxZWwCjrxfIUSQJOIQTIjgNEkQnYLXed_Wbf2Rm7ztI13ZaOmqn4-8sp1xNkr7yNS62ALbR1YE2r9Fa920uSmcj7wu10PNq-hFyMi4ovDH4CDThXcnuzoDz7c3T_N7uHi8e5hfL6BhiWyhxhYJk0pkMy0IFtZZKVhmqU2y0Em1TrmkKHOUceokoyYzlkiSIiuNIZzOwMWYu27q9875VpW5Hy7Qlas7r3DCOMMxZgN6_gdd1V1ThesCRWUsGEdxoPBImab2vnGZWjd5qZteYaQG92p0r4J7NbhXmzBztkvu0tLZ74kv2QEgI-BDq1q65tfqf1M_AW9ckAU</recordid><startdate>20161201</startdate><enddate>20161201</enddate><creator>León-Mejía, Grethel</creator><creator>Silva, Luis F. 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O.</au><au>Civeira, Matheus S.</au><au>Oliveira, Marcos L. S.</au><au>Machado, Miriana</au><au>Villela, Izabel Vianna</au><au>Hartmann, Andreas</au><au>Premoli, Suziane</au><au>Corrêa, Dione Silva</au><au>Da Silva, Juliana</au><au>Henriques, João Antônio Pêgas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cytotoxicity and genotoxicity induced by coal and coal fly ash particles samples in V79 cells</atitle><jtitle>Environmental science and pollution research international</jtitle><stitle>Environ Sci Pollut Res</stitle><addtitle>Environ Sci Pollut Res Int</addtitle><date>2016-12-01</date><risdate>2016</risdate><volume>23</volume><issue>23</issue><spage>24019</spage><epage>24031</epage><pages>24019-24031</pages><issn>0944-1344</issn><eissn>1614-7499</eissn><abstract>Exposure to coal and coal ashes can cause harmful effects in in vitro and in vivo systems, mainly by the induction of oxidative damage. The aim of this work was to assess cytotoxic and genotoxic effects using the V79 cell line treated with coal and coal fly ash particles derived from a coal power plant located in Santa Catarina, Brazil. Two coal samples (COAL11 and COAL16) and two coal fly ash samples (CFA11 and CFA16) were included in this study. COAL16 was co-firing with a mixture of fuel oil and diesel oil. The comet assay data showed that exposure of V79 cells to coal and coal fly ash particles induced primary DNA lesions. Application of lesion-specific endonucleases (FPG and ENDO III) demonstrated increased DNA effects indicating the presence of high amounts of oxidative DNA lesions. The cytokinesis-block micronucleus cytome assay analysis showed that exposure of V79 cells to high concentrations of coal and coal fly ash particles induced cytotoxic effects (apoptosis and necrosis) and chromosomal instability (nucleoplasmic bridges, nuclear buds, and micronucleus (MN) formation). These results may be associated with compounds contained in the surface of the particles as hazardous elements, ultrafine/nanoparticles, and polycyclic aromatic hydrocarbons (PAHs) which were detected in the samples.
Graphical abstract
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| subjects | Aquatic Pollution Atmospheric Protection/Air Quality Control/Air Pollution Bioassays Brazil Cell Line Coal Coal - analysis Coal - toxicity Coal Ash - analysis Coal Ash - toxicity Coal mining Coal-fired power plants Comet Assay Cytotoxicity Deoxyribonucleic acid DNA DNA Damage Earth and Environmental Science Ecotoxicology Electrons Environment Environmental Chemistry Environmental Health Environmental impact Environmental science Fly ash Genotoxicity Humans Lesions Nanoparticles - analysis Nanoparticles - toxicity Polycyclic aromatic hydrocarbons Polycyclic Aromatic Hydrocarbons - analysis Polycyclic Aromatic Hydrocarbons - toxicity Power Plants Research Article Scientific imaging Studies Waste Water Technology Water Management Water Pollution Control |
| title | Cytotoxicity and genotoxicity induced by coal and coal fly ash particles samples in V79 cells |
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