Monitoring and functional characterization of the lymphocytic compartment in pancreatic ductal adenocarcinoma patients

Abstract Background/Objectives Pancreatic ductal adenocarcinoma (PDAC) still has a poor prognosis and current treatments including immunotherapy often fail. This might be due to the pronounced immunosuppressive milieu impairing infiltration and function of immune effector cells. This study aimed at...

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Veröffentlicht in:	Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 2016-11, Vol.16 (6), p.1069-1079
Hauptverfasser:	Oberg, Hans-Heinrich, Grage-Griebenow, Evelin, Adam-Klages, Sabine, Jerg, Elfi, Peipp, Matthias, Kellner, Christian, Petrick, Domantas, Gonnermann, Daniel, Freitag-Wolf, Sandra, Röcken, Christoph, Sebens, Thorsten, Vogel, Ilka, Becker, Thomas, Ebsen, Michael, Kabelitz, Dieter, Wesch, Daniela, Sebens, Susanne
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Antineoplastic Agents - therapeutic use Carcinoma, Pancreatic Ductal - drug therapy Carcinoma, Pancreatic Ductal - immunology Carcinoma, Pancreatic Ductal - pathology CD4-Positive T-Lymphocytes - immunology Chemotherapy Cloning Endocrinology & Metabolism Epithelium - pathology Female Flow Cytometry Gastroenterology and Hepatology Humans Immune escape Immune status Immune therapy Immunohistochemistry Immunotherapy Leukocyte Count Lymphatic system Lymphocytes Lymphocytes - immunology Male Medical prognosis Middle Aged Monitoring, Physiologic Pancreatic cancer Pancreatic Ducts - pathology Pancreatic Neoplasms - drug therapy Pancreatic Neoplasms - immunology Pancreatic Neoplasms - pathology Patients Receptor, ErbB-2 - genetics Receptor, ErbB-2 - metabolism T-Lymphocytes, Regulatory - immunology Thoracic surgery Trastuzumab - therapeutic use γδ T cells
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