Anti-arthritogenic and cardioprotective action of hesperidin and daidzein in collagen-induced rheumatoid arthritis
Atherosclerosis has been linked to chronic inflammatory processes. Changes in the levels of lipoproteins, especially low-density lipoprotein or its variants, as well as inflammatory markers are risk factors for the atherosclerosis. In the present study, an experimental model of rheumatoid arthritis...
Gespeichert in:
| Veröffentlicht in: | Molecular and cellular biochemistry 2016-12, Vol.423 (1-2), p.115-127 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 127 |
|---|---|
| container_issue | 1-2 |
| container_start_page | 115 |
| container_title | Molecular and cellular biochemistry |
| container_volume | 423 |
| creator | Ahmad, Shafeeque Alam, Khursheed Hossain, M. Mobarak Fatima, Mahino Firdaus, Fakiha Zafeer, Mohammad Faraz Arif, Zarina Ahmed, Murad Nafees, K. A. |
| description | Atherosclerosis has been linked to chronic inflammatory processes. Changes in the levels of lipoproteins, especially low-density lipoprotein or its variants, as well as inflammatory markers are risk factors for the atherosclerosis. In the present study, an experimental model of rheumatoid arthritis was developed by administrating collagen suspension intradermally in the tail region of Wistar albino rats. At the same time, a suspension of hesperidin (50 mg/kg body weight) and daidzein (20 mg/kg body weight) was orally administrated. The compounds were given in the morning and evening for 21 days. Levels of inflammatory markers in the homogenate of knee joints of experimental rats as well as plasma lipoproteins were investigated. The administration of hesperidin and daidzein caused significant (
p
|
| doi_str_mv | 10.1007/s11010-016-2830-y |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_1846413957</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A470636438</galeid><sourcerecordid>A470636438</sourcerecordid><originalsourceid>FETCH-LOGICAL-c472t-d242cef8c80f284f5fbf4f63c4178e8f7dffbd4668ef03f23e2af314247a7eb63</originalsourceid><addsrcrecordid>eNqFkluLWyEUhaW0dNJpf0BfyoG-9MWpt6PmMQy9wUBf2mcxuk0ccjRVTyHz62sm6ZWWoiDqt5d7yULoOSVXlBD1ulJKKMGESsw0J_jwAC3oqDgWS7p8iBaEE4I1VeoCPan1lnSYUPoYXTCliBBSLlBZpRaxLW1bYssbSNENNvnB2eJj3pfcwLX4FQbbl5yGHIYt1D2U6GO6J72N_g76pk-XdzvbRXBMfnbgh7KFebItRz-c34j1KXoU7K7Cs_N6iT6_ffPp-j2--fjuw_XqBjuhWMOeCeYgaKdJYFqEMayDCJI7QZUGHZQPYe27CQ2B8MA4MBs4FUwoq2At-SV6ddLtLr7MUJuZYnXQO0yQ52qoFlJQvuwf9n-Uj3xU4zh29OUf6G2eS-pG7ikp2cjZT2pjd2BiCrkV646iZiUUkVwKrjt19ReqDw9TdDlBiP38twJ6KnAl11ogmH2Jky0HQ4k5RsKcImF6JMwxEubQa16cG57XE_gfFd8z0AF2Amq_Shsovzj6p-o3f5fByg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1835662532</pqid></control><display><type>article</type><title>Anti-arthritogenic and cardioprotective action of hesperidin and daidzein in collagen-induced rheumatoid arthritis</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>Ahmad, Shafeeque ; Alam, Khursheed ; Hossain, M. Mobarak ; Fatima, Mahino ; Firdaus, Fakiha ; Zafeer, Mohammad Faraz ; Arif, Zarina ; Ahmed, Murad ; Nafees, K. A.</creator><creatorcontrib>Ahmad, Shafeeque ; Alam, Khursheed ; Hossain, M. Mobarak ; Fatima, Mahino ; Firdaus, Fakiha ; Zafeer, Mohammad Faraz ; Arif, Zarina ; Ahmed, Murad ; Nafees, K. A.</creatorcontrib><description>Atherosclerosis has been linked to chronic inflammatory processes. Changes in the levels of lipoproteins, especially low-density lipoprotein or its variants, as well as inflammatory markers are risk factors for the atherosclerosis. In the present study, an experimental model of rheumatoid arthritis was developed by administrating collagen suspension intradermally in the tail region of Wistar albino rats. At the same time, a suspension of hesperidin (50 mg/kg body weight) and daidzein (20 mg/kg body weight) was orally administrated. The compounds were given in the morning and evening for 21 days. Levels of inflammatory markers in the homogenate of knee joints of experimental rats as well as plasma lipoproteins were investigated. The administration of hesperidin and daidzein caused significant (
p
< 0.001) decrease in articular elastase activity, TNF-α, and malondialdehyde levels. Further, arthritis scoring and histological findings supported the anti-inflammatory actions of the test compounds. Interestingly, the test compounds also lowered the plasma low-density lipoprotein cholesterol, very low-density lipoprotein cholesterol, and triglyceride but increased the level of high-density lipoprotein cholesterol. The test compounds thus ameliorated the risk factors of atherosclerosis. Furthermore, antioxidant roles of hesperidin as well as daidzein were evident from decrease in free radical load demonstrated as increase in total antioxidant level in plasma of arthritic animals treated with hesperidin and daidzein. In a separate in vitro experiment, enhanced free radical scavenging activity of hesperidin was demonstrated against 2,2-diphenyl-1-picrylhydrazyl and 2,2-azinobis-3-ethylbenzothiazoline-6-sulfonic acid. The anti-inflammatory, hypolipidemic, and antioxidant actions of the naturally occurring test compounds, particularly hesperidin, seem to be quite effective against rheumatoid arthritis and atherosclerosis. Thus, their consumption may be helpful in prevention or at least delaying the onset of these diseases in susceptible individuals.</description><identifier>ISSN: 0300-8177</identifier><identifier>EISSN: 1573-4919</identifier><identifier>DOI: 10.1007/s11010-016-2830-y</identifier><identifier>PMID: 27704466</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Animals ; Antioxidants ; Arthritis ; Arthritis, Rheumatoid - chemically induced ; Arthritis, Rheumatoid - drug therapy ; Arthritis, Rheumatoid - metabolism ; Atherosclerosis ; Autoimmune diseases ; Biochemistry ; Biomedical and Life Sciences ; Blood lipids ; Body weight ; Cardiology ; Cardiotonic Agents - pharmacology ; Cholesterol ; Collagen ; Collagen - toxicity ; Disease susceptibility ; Hesperidin - pharmacology ; Isoflavones ; Isoflavones - pharmacology ; Life Sciences ; Low density lipoproteins ; Male ; Medical Biochemistry ; Oncology ; Rats ; Rats, Wistar ; Rheumatoid arthritis ; Rheumatoid factor ; Risk factors ; Triglycerides</subject><ispartof>Molecular and cellular biochemistry, 2016-12, Vol.423 (1-2), p.115-127</ispartof><rights>Springer Science+Business Media New York 2016</rights><rights>COPYRIGHT 2016 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c472t-d242cef8c80f284f5fbf4f63c4178e8f7dffbd4668ef03f23e2af314247a7eb63</citedby><cites>FETCH-LOGICAL-c472t-d242cef8c80f284f5fbf4f63c4178e8f7dffbd4668ef03f23e2af314247a7eb63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11010-016-2830-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11010-016-2830-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27704466$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ahmad, Shafeeque</creatorcontrib><creatorcontrib>Alam, Khursheed</creatorcontrib><creatorcontrib>Hossain, M. Mobarak</creatorcontrib><creatorcontrib>Fatima, Mahino</creatorcontrib><creatorcontrib>Firdaus, Fakiha</creatorcontrib><creatorcontrib>Zafeer, Mohammad Faraz</creatorcontrib><creatorcontrib>Arif, Zarina</creatorcontrib><creatorcontrib>Ahmed, Murad</creatorcontrib><creatorcontrib>Nafees, K. A.</creatorcontrib><title>Anti-arthritogenic and cardioprotective action of hesperidin and daidzein in collagen-induced rheumatoid arthritis</title><title>Molecular and cellular biochemistry</title><addtitle>Mol Cell Biochem</addtitle><addtitle>Mol Cell Biochem</addtitle><description>Atherosclerosis has been linked to chronic inflammatory processes. Changes in the levels of lipoproteins, especially low-density lipoprotein or its variants, as well as inflammatory markers are risk factors for the atherosclerosis. In the present study, an experimental model of rheumatoid arthritis was developed by administrating collagen suspension intradermally in the tail region of Wistar albino rats. At the same time, a suspension of hesperidin (50 mg/kg body weight) and daidzein (20 mg/kg body weight) was orally administrated. The compounds were given in the morning and evening for 21 days. Levels of inflammatory markers in the homogenate of knee joints of experimental rats as well as plasma lipoproteins were investigated. The administration of hesperidin and daidzein caused significant (
p
< 0.001) decrease in articular elastase activity, TNF-α, and malondialdehyde levels. Further, arthritis scoring and histological findings supported the anti-inflammatory actions of the test compounds. Interestingly, the test compounds also lowered the plasma low-density lipoprotein cholesterol, very low-density lipoprotein cholesterol, and triglyceride but increased the level of high-density lipoprotein cholesterol. The test compounds thus ameliorated the risk factors of atherosclerosis. Furthermore, antioxidant roles of hesperidin as well as daidzein were evident from decrease in free radical load demonstrated as increase in total antioxidant level in plasma of arthritic animals treated with hesperidin and daidzein. In a separate in vitro experiment, enhanced free radical scavenging activity of hesperidin was demonstrated against 2,2-diphenyl-1-picrylhydrazyl and 2,2-azinobis-3-ethylbenzothiazoline-6-sulfonic acid. The anti-inflammatory, hypolipidemic, and antioxidant actions of the naturally occurring test compounds, particularly hesperidin, seem to be quite effective against rheumatoid arthritis and atherosclerosis. Thus, their consumption may be helpful in prevention or at least delaying the onset of these diseases in susceptible individuals.</description><subject>Animals</subject><subject>Antioxidants</subject><subject>Arthritis</subject><subject>Arthritis, Rheumatoid - chemically induced</subject><subject>Arthritis, Rheumatoid - drug therapy</subject><subject>Arthritis, Rheumatoid - metabolism</subject><subject>Atherosclerosis</subject><subject>Autoimmune diseases</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Blood lipids</subject><subject>Body weight</subject><subject>Cardiology</subject><subject>Cardiotonic Agents - pharmacology</subject><subject>Cholesterol</subject><subject>Collagen</subject><subject>Collagen - toxicity</subject><subject>Disease susceptibility</subject><subject>Hesperidin - pharmacology</subject><subject>Isoflavones</subject><subject>Isoflavones - pharmacology</subject><subject>Life Sciences</subject><subject>Low density lipoproteins</subject><subject>Male</subject><subject>Medical Biochemistry</subject><subject>Oncology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Rheumatoid arthritis</subject><subject>Rheumatoid factor</subject><subject>Risk factors</subject><subject>Triglycerides</subject><issn>0300-8177</issn><issn>1573-4919</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkluLWyEUhaW0dNJpf0BfyoG-9MWpt6PmMQy9wUBf2mcxuk0ccjRVTyHz62sm6ZWWoiDqt5d7yULoOSVXlBD1ulJKKMGESsw0J_jwAC3oqDgWS7p8iBaEE4I1VeoCPan1lnSYUPoYXTCliBBSLlBZpRaxLW1bYssbSNENNvnB2eJj3pfcwLX4FQbbl5yGHIYt1D2U6GO6J72N_g76pk-XdzvbRXBMfnbgh7KFebItRz-c34j1KXoU7K7Cs_N6iT6_ffPp-j2--fjuw_XqBjuhWMOeCeYgaKdJYFqEMayDCJI7QZUGHZQPYe27CQ2B8MA4MBs4FUwoq2At-SV6ddLtLr7MUJuZYnXQO0yQ52qoFlJQvuwf9n-Uj3xU4zh29OUf6G2eS-pG7ikp2cjZT2pjd2BiCrkV646iZiUUkVwKrjt19ReqDw9TdDlBiP38twJ6KnAl11ogmH2Jky0HQ4k5RsKcImF6JMwxEubQa16cG57XE_gfFd8z0AF2Amq_Shsovzj6p-o3f5fByg</recordid><startdate>20161201</startdate><enddate>20161201</enddate><creator>Ahmad, Shafeeque</creator><creator>Alam, Khursheed</creator><creator>Hossain, M. Mobarak</creator><creator>Fatima, Mahino</creator><creator>Firdaus, Fakiha</creator><creator>Zafeer, Mohammad Faraz</creator><creator>Arif, Zarina</creator><creator>Ahmed, Murad</creator><creator>Nafees, K. A.</creator><general>Springer US</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QP</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20161201</creationdate><title>Anti-arthritogenic and cardioprotective action of hesperidin and daidzein in collagen-induced rheumatoid arthritis</title><author>Ahmad, Shafeeque ; Alam, Khursheed ; Hossain, M. Mobarak ; Fatima, Mahino ; Firdaus, Fakiha ; Zafeer, Mohammad Faraz ; Arif, Zarina ; Ahmed, Murad ; Nafees, K. A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c472t-d242cef8c80f284f5fbf4f63c4178e8f7dffbd4668ef03f23e2af314247a7eb63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Animals</topic><topic>Antioxidants</topic><topic>Arthritis</topic><topic>Arthritis, Rheumatoid - chemically induced</topic><topic>Arthritis, Rheumatoid - drug therapy</topic><topic>Arthritis, Rheumatoid - metabolism</topic><topic>Atherosclerosis</topic><topic>Autoimmune diseases</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Blood lipids</topic><topic>Body weight</topic><topic>Cardiology</topic><topic>Cardiotonic Agents - pharmacology</topic><topic>Cholesterol</topic><topic>Collagen</topic><topic>Collagen - toxicity</topic><topic>Disease susceptibility</topic><topic>Hesperidin - pharmacology</topic><topic>Isoflavones</topic><topic>Isoflavones - pharmacology</topic><topic>Life Sciences</topic><topic>Low density lipoproteins</topic><topic>Male</topic><topic>Medical Biochemistry</topic><topic>Oncology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Rheumatoid arthritis</topic><topic>Rheumatoid factor</topic><topic>Risk factors</topic><topic>Triglycerides</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ahmad, Shafeeque</creatorcontrib><creatorcontrib>Alam, Khursheed</creatorcontrib><creatorcontrib>Hossain, M. Mobarak</creatorcontrib><creatorcontrib>Fatima, Mahino</creatorcontrib><creatorcontrib>Firdaus, Fakiha</creatorcontrib><creatorcontrib>Zafeer, Mohammad Faraz</creatorcontrib><creatorcontrib>Arif, Zarina</creatorcontrib><creatorcontrib>Ahmed, Murad</creatorcontrib><creatorcontrib>Nafees, K. A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Molecular and cellular biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ahmad, Shafeeque</au><au>Alam, Khursheed</au><au>Hossain, M. Mobarak</au><au>Fatima, Mahino</au><au>Firdaus, Fakiha</au><au>Zafeer, Mohammad Faraz</au><au>Arif, Zarina</au><au>Ahmed, Murad</au><au>Nafees, K. A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anti-arthritogenic and cardioprotective action of hesperidin and daidzein in collagen-induced rheumatoid arthritis</atitle><jtitle>Molecular and cellular biochemistry</jtitle><stitle>Mol Cell Biochem</stitle><addtitle>Mol Cell Biochem</addtitle><date>2016-12-01</date><risdate>2016</risdate><volume>423</volume><issue>1-2</issue><spage>115</spage><epage>127</epage><pages>115-127</pages><issn>0300-8177</issn><eissn>1573-4919</eissn><abstract>Atherosclerosis has been linked to chronic inflammatory processes. Changes in the levels of lipoproteins, especially low-density lipoprotein or its variants, as well as inflammatory markers are risk factors for the atherosclerosis. In the present study, an experimental model of rheumatoid arthritis was developed by administrating collagen suspension intradermally in the tail region of Wistar albino rats. At the same time, a suspension of hesperidin (50 mg/kg body weight) and daidzein (20 mg/kg body weight) was orally administrated. The compounds were given in the morning and evening for 21 days. Levels of inflammatory markers in the homogenate of knee joints of experimental rats as well as plasma lipoproteins were investigated. The administration of hesperidin and daidzein caused significant (
p
< 0.001) decrease in articular elastase activity, TNF-α, and malondialdehyde levels. Further, arthritis scoring and histological findings supported the anti-inflammatory actions of the test compounds. Interestingly, the test compounds also lowered the plasma low-density lipoprotein cholesterol, very low-density lipoprotein cholesterol, and triglyceride but increased the level of high-density lipoprotein cholesterol. The test compounds thus ameliorated the risk factors of atherosclerosis. Furthermore, antioxidant roles of hesperidin as well as daidzein were evident from decrease in free radical load demonstrated as increase in total antioxidant level in plasma of arthritic animals treated with hesperidin and daidzein. In a separate in vitro experiment, enhanced free radical scavenging activity of hesperidin was demonstrated against 2,2-diphenyl-1-picrylhydrazyl and 2,2-azinobis-3-ethylbenzothiazoline-6-sulfonic acid. The anti-inflammatory, hypolipidemic, and antioxidant actions of the naturally occurring test compounds, particularly hesperidin, seem to be quite effective against rheumatoid arthritis and atherosclerosis. Thus, their consumption may be helpful in prevention or at least delaying the onset of these diseases in susceptible individuals.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>27704466</pmid><doi>10.1007/s11010-016-2830-y</doi><tpages>13</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0300-8177 |
| ispartof | Molecular and cellular biochemistry, 2016-12, Vol.423 (1-2), p.115-127 |
| issn | 0300-8177 1573-4919 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1846413957 |
| source | MEDLINE; SpringerNature Journals |
| subjects | Animals Antioxidants Arthritis Arthritis, Rheumatoid - chemically induced Arthritis, Rheumatoid - drug therapy Arthritis, Rheumatoid - metabolism Atherosclerosis Autoimmune diseases Biochemistry Biomedical and Life Sciences Blood lipids Body weight Cardiology Cardiotonic Agents - pharmacology Cholesterol Collagen Collagen - toxicity Disease susceptibility Hesperidin - pharmacology Isoflavones Isoflavones - pharmacology Life Sciences Low density lipoproteins Male Medical Biochemistry Oncology Rats Rats, Wistar Rheumatoid arthritis Rheumatoid factor Risk factors Triglycerides |
| title | Anti-arthritogenic and cardioprotective action of hesperidin and daidzein in collagen-induced rheumatoid arthritis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-26T11%3A57%3A13IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Anti-arthritogenic%20and%20cardioprotective%20action%20of%20hesperidin%20and%20daidzein%20in%20collagen-induced%20rheumatoid%20arthritis&rft.jtitle=Molecular%20and%20cellular%20biochemistry&rft.au=Ahmad,%20Shafeeque&rft.date=2016-12-01&rft.volume=423&rft.issue=1-2&rft.spage=115&rft.epage=127&rft.pages=115-127&rft.issn=0300-8177&rft.eissn=1573-4919&rft_id=info:doi/10.1007/s11010-016-2830-y&rft_dat=%3Cgale_proqu%3EA470636438%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1835662532&rft_id=info:pmid/27704466&rft_galeid=A470636438&rfr_iscdi=true |