Are Inflammatory Biomarkers Increased in Varicose Vein Blood?
Objectives: To test for the presence of inflammatory biomarkers in blood taken from varicose veins versus antecubital blood of the same patient and compare this to levels in healthy controls. Methods: Using a multiplex biochip array method (Randox, United Kingdom), the interleukins (ILs) IL-1α, IL-1...
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| Veröffentlicht in: | Clinical and applied thrombosis/hemostasis 2016-10, Vol.22 (7), p.656-664 |
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| creator | Lattimer, Christopher R. Kalodiki, Evi Geroulakos, George Hoppensteadt, Debra Fareed, Jawed |
| description | Objectives:
To test for the presence of inflammatory biomarkers in blood taken from varicose veins versus antecubital blood of the same patient and compare this to levels in healthy controls.
Methods:
Using a multiplex biochip array method (Randox, United Kingdom), the interleukins (ILs) IL-1α, IL-1β, IL-2, IL-4, IL-6, IL-8, and IL-10; vascular endothelial growth factor; interferon γ, tumor necrosis factor α ; monocyte chemotactic protein 1 (MCP-1); and epidermal growth factor were measured in citrated plasma samples drawn from the arms and legs of 24 patients with varicose veins and 24 controls.
Results:
Expressed as median (interquartile range) in pg/mL, leg samples from patients with varicose veins had significantly higher levels of IL-8 and MCP-1 compared to their own arm samples (IL-8: local 2.3 [1.71-3.3] vs systemic 2.3 [1.62-2.98], P = .023; MCP-1: local 114.42 [84.29-139.05] vs systemic 103.56 [79.75-126.42], P < .0005). This was not observed in the control group. Leg samples from both patients with varicose vein and controls had higher levels of IL-6 compared to their own arm samples (patients: local 1.67 [0.82-4.48] vs systemic 1.24 [0.58-3.26], P = .002; controls: local 1.23 [0.83-1.7] vs systemic 1.03 [1.7-1.52], P = .005). No significant differences were detected with the other biomarkers.
Conclusions:
Blood drawn from the site of varicose veins appears to have significantly increased concentrations of IL-6, IL-8, and MCP-1 when compared to the same patient’s arm blood. This supports the hypothesis that inflammation is activated from the tissues drained by the varicose veins. |
| doi_str_mv | 10.1177/1076029616645330 |
| format | Article |
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To test for the presence of inflammatory biomarkers in blood taken from varicose veins versus antecubital blood of the same patient and compare this to levels in healthy controls.
Methods:
Using a multiplex biochip array method (Randox, United Kingdom), the interleukins (ILs) IL-1α, IL-1β, IL-2, IL-4, IL-6, IL-8, and IL-10; vascular endothelial growth factor; interferon γ, tumor necrosis factor α ; monocyte chemotactic protein 1 (MCP-1); and epidermal growth factor were measured in citrated plasma samples drawn from the arms and legs of 24 patients with varicose veins and 24 controls.
Results:
Expressed as median (interquartile range) in pg/mL, leg samples from patients with varicose veins had significantly higher levels of IL-8 and MCP-1 compared to their own arm samples (IL-8: local 2.3 [1.71-3.3] vs systemic 2.3 [1.62-2.98], P = .023; MCP-1: local 114.42 [84.29-139.05] vs systemic 103.56 [79.75-126.42], P < .0005). This was not observed in the control group. Leg samples from both patients with varicose vein and controls had higher levels of IL-6 compared to their own arm samples (patients: local 1.67 [0.82-4.48] vs systemic 1.24 [0.58-3.26], P = .002; controls: local 1.23 [0.83-1.7] vs systemic 1.03 [1.7-1.52], P = .005). No significant differences were detected with the other biomarkers.
Conclusions:
Blood drawn from the site of varicose veins appears to have significantly increased concentrations of IL-6, IL-8, and MCP-1 when compared to the same patient’s arm blood. This supports the hypothesis that inflammation is activated from the tissues drained by the varicose veins.</description><identifier>ISSN: 1076-0296</identifier><identifier>EISSN: 1938-2723</identifier><identifier>DOI: 10.1177/1076029616645330</identifier><identifier>PMID: 27103338</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Biomarkers ; Biomarkers - blood ; Chronic Disease ; Cytokines - blood ; Female ; Growth factors ; Humans ; Inflammation ; Male ; Middle Aged ; Patients ; Varicose veins ; Varicose Veins - blood ; Venous Insufficiency - blood</subject><ispartof>Clinical and applied thrombosis/hemostasis, 2016-10, Vol.22 (7), p.656-664</ispartof><rights>The Author(s) 2016</rights><rights>The Author(s) 2016.</rights><rights>The Author(s) 2016. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the associated terms available at: https://uk.sagepub.com/en-gb/eur/reusing-open-access-and-sage-choice-content</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c506t-dbd5332be2e31ec2a0c1c1e043cff5a6354e3363a3733529790f2f29f3337e143</citedby><cites>FETCH-LOGICAL-c506t-dbd5332be2e31ec2a0c1c1e043cff5a6354e3363a3733529790f2f29f3337e143</cites><orcidid>0000-0002-0282-4826 ; 0000-0003-0310-2726</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/1076029616645330$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/1076029616645330$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,776,780,21945,27830,27901,27902,44921,45309</link.rule.ids><linktorsrc>$$Uhttps://journals.sagepub.com/doi/full/10.1177/1076029616645330?utm_source=summon&utm_medium=discovery-provider$$EView_record_in_SAGE_Publications$$FView_record_in_$$GSAGE_Publications</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27103338$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lattimer, Christopher R.</creatorcontrib><creatorcontrib>Kalodiki, Evi</creatorcontrib><creatorcontrib>Geroulakos, George</creatorcontrib><creatorcontrib>Hoppensteadt, Debra</creatorcontrib><creatorcontrib>Fareed, Jawed</creatorcontrib><title>Are Inflammatory Biomarkers Increased in Varicose Vein Blood?</title><title>Clinical and applied thrombosis/hemostasis</title><addtitle>Clin Appl Thromb Hemost</addtitle><description>Objectives:
To test for the presence of inflammatory biomarkers in blood taken from varicose veins versus antecubital blood of the same patient and compare this to levels in healthy controls.
Methods:
Using a multiplex biochip array method (Randox, United Kingdom), the interleukins (ILs) IL-1α, IL-1β, IL-2, IL-4, IL-6, IL-8, and IL-10; vascular endothelial growth factor; interferon γ, tumor necrosis factor α ; monocyte chemotactic protein 1 (MCP-1); and epidermal growth factor were measured in citrated plasma samples drawn from the arms and legs of 24 patients with varicose veins and 24 controls.
Results:
Expressed as median (interquartile range) in pg/mL, leg samples from patients with varicose veins had significantly higher levels of IL-8 and MCP-1 compared to their own arm samples (IL-8: local 2.3 [1.71-3.3] vs systemic 2.3 [1.62-2.98], P = .023; MCP-1: local 114.42 [84.29-139.05] vs systemic 103.56 [79.75-126.42], P < .0005). This was not observed in the control group. Leg samples from both patients with varicose vein and controls had higher levels of IL-6 compared to their own arm samples (patients: local 1.67 [0.82-4.48] vs systemic 1.24 [0.58-3.26], P = .002; controls: local 1.23 [0.83-1.7] vs systemic 1.03 [1.7-1.52], P = .005). No significant differences were detected with the other biomarkers.
Conclusions:
Blood drawn from the site of varicose veins appears to have significantly increased concentrations of IL-6, IL-8, and MCP-1 when compared to the same patient’s arm blood. This supports the hypothesis that inflammation is activated from the tissues drained by the varicose veins.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biomarkers</subject><subject>Biomarkers - blood</subject><subject>Chronic Disease</subject><subject>Cytokines - blood</subject><subject>Female</subject><subject>Growth factors</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Patients</subject><subject>Varicose veins</subject><subject>Varicose Veins - blood</subject><subject>Venous Insufficiency - blood</subject><issn>1076-0296</issn><issn>1938-2723</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNkU1LxDAQhoMorq7ePUnBi5dqJtMmzUFkXfwCwYt6Ldl0Il3bzZpsD_57I-sHCIKnTDLPvJl5h7ED4CcASp0CV5ILLUHKokTkG2wHNFa5UAI3U5zS-Ud-xHZjnHMOWmq5zUZCAUfEaoedTQJltwvXmb43Kx_esovW9ya8UIjp3QYykZqsXWRPJrTWR8qeKN0uOu-b8z225UwXaf_zHLPHq8uH6U1-d399O53c5bbkcpU3syZ1J2YkCIGsMNyCBeIFWudKI7EsCFGiQYVYCq00d8IJ7VKPiqDAMTte6y6Dfx0oruq-jZa6zizID7GGqpAFCF1V_0Ch1Mk1UAk9-oXO_RAWaZBaYFEIXsqKJ4qvKRt8jIFcvQxtcuitBl5_bKH-vYVUcvgpPMx6ar4LvmxPQL4Gonmmn1__FHwHzpCLNA</recordid><startdate>20161001</startdate><enddate>20161001</enddate><creator>Lattimer, Christopher R.</creator><creator>Kalodiki, Evi</creator><creator>Geroulakos, George</creator><creator>Hoppensteadt, Debra</creator><creator>Fareed, Jawed</creator><general>SAGE Publications</general><general>SAGE PUBLICATIONS, INC</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><orcidid>https://orcid.org/0000-0002-0282-4826</orcidid><orcidid>https://orcid.org/0000-0003-0310-2726</orcidid></search><sort><creationdate>20161001</creationdate><title>Are Inflammatory Biomarkers Increased in Varicose Vein Blood?</title><author>Lattimer, Christopher R. ; Kalodiki, Evi ; Geroulakos, George ; Hoppensteadt, Debra ; Fareed, Jawed</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c506t-dbd5332be2e31ec2a0c1c1e043cff5a6354e3363a3733529790f2f29f3337e143</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biomarkers</topic><topic>Biomarkers - blood</topic><topic>Chronic Disease</topic><topic>Cytokines - blood</topic><topic>Female</topic><topic>Growth factors</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Patients</topic><topic>Varicose veins</topic><topic>Varicose Veins - blood</topic><topic>Venous Insufficiency - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lattimer, Christopher R.</creatorcontrib><creatorcontrib>Kalodiki, Evi</creatorcontrib><creatorcontrib>Geroulakos, George</creatorcontrib><creatorcontrib>Hoppensteadt, Debra</creatorcontrib><creatorcontrib>Fareed, Jawed</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Clinical and applied thrombosis/hemostasis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Lattimer, Christopher R.</au><au>Kalodiki, Evi</au><au>Geroulakos, George</au><au>Hoppensteadt, Debra</au><au>Fareed, Jawed</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Are Inflammatory Biomarkers Increased in Varicose Vein Blood?</atitle><jtitle>Clinical and applied thrombosis/hemostasis</jtitle><addtitle>Clin Appl Thromb Hemost</addtitle><date>2016-10-01</date><risdate>2016</risdate><volume>22</volume><issue>7</issue><spage>656</spage><epage>664</epage><pages>656-664</pages><issn>1076-0296</issn><eissn>1938-2723</eissn><abstract>Objectives:
To test for the presence of inflammatory biomarkers in blood taken from varicose veins versus antecubital blood of the same patient and compare this to levels in healthy controls.
Methods:
Using a multiplex biochip array method (Randox, United Kingdom), the interleukins (ILs) IL-1α, IL-1β, IL-2, IL-4, IL-6, IL-8, and IL-10; vascular endothelial growth factor; interferon γ, tumor necrosis factor α ; monocyte chemotactic protein 1 (MCP-1); and epidermal growth factor were measured in citrated plasma samples drawn from the arms and legs of 24 patients with varicose veins and 24 controls.
Results:
Expressed as median (interquartile range) in pg/mL, leg samples from patients with varicose veins had significantly higher levels of IL-8 and MCP-1 compared to their own arm samples (IL-8: local 2.3 [1.71-3.3] vs systemic 2.3 [1.62-2.98], P = .023; MCP-1: local 114.42 [84.29-139.05] vs systemic 103.56 [79.75-126.42], P < .0005). This was not observed in the control group. Leg samples from both patients with varicose vein and controls had higher levels of IL-6 compared to their own arm samples (patients: local 1.67 [0.82-4.48] vs systemic 1.24 [0.58-3.26], P = .002; controls: local 1.23 [0.83-1.7] vs systemic 1.03 [1.7-1.52], P = .005). No significant differences were detected with the other biomarkers.
Conclusions:
Blood drawn from the site of varicose veins appears to have significantly increased concentrations of IL-6, IL-8, and MCP-1 when compared to the same patient’s arm blood. This supports the hypothesis that inflammation is activated from the tissues drained by the varicose veins.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>27103338</pmid><doi>10.1177/1076029616645330</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-0282-4826</orcidid><orcidid>https://orcid.org/0000-0003-0310-2726</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Clinical and applied thrombosis/hemostasis, 2016-10, Vol.22 (7), p.656-664 |
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| source | Sage Journals GOLD Open Access 2024 |
| subjects | Adult Aged Aged, 80 and over Biomarkers Biomarkers - blood Chronic Disease Cytokines - blood Female Growth factors Humans Inflammation Male Middle Aged Patients Varicose veins Varicose Veins - blood Venous Insufficiency - blood |
| title | Are Inflammatory Biomarkers Increased in Varicose Vein Blood? |
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