Curcumin Monoglucoside Shows Improved Bioavailability and Mitigates Rotenone Induced Neurotoxicity in Cell and Drosophila Models of Parkinson’s Disease

Curcumin (CUR), a dietary polyphenol has diverse pharmacologic effects, but is limited by poor bioavailability. This is probably due to decreased solubility, cellular uptake and stability. In order to enhance its solubility and bioavailability, we synthesized the CUR bioconjugate curcumin monoglucos...

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Veröffentlicht in:	Neurochemical research 2016-11, Vol.41 (11), p.3113-3128
Hauptverfasser:	Pandareesh, M. D., Shrivash, M. K., Naveen Kumar, H. N., Misra, K., Srinivas Bharath, M. M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants - pharmacology Biochemistry Biomedical and Life Sciences Biomedicine Cell Biology Curcumin - pharmacology Disease Models, Animal Dopaminergic Neurons - drug effects Down-Regulation - drug effects Drosophila Drosophila melanogaster Neurochemistry Neurology Neurosciences Original Paper Oxidative Stress - drug effects Rats Rotenone - pharmacology Up-Regulation - drug effects
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