Changes in nociceptin/orphanin FQ levels in rat brain regions after acute and chronic cannabinoid treatment in conjunction with the development of antinociceptive tolerance

It has been indicated that acute and chronic morphine administrations enhance nociceptin/orphanin FQ (N/OFQ) levels in the brain, which might play role in the development of tolerance to the antinociceptive effect of morphine. Accordingly, N/OFQ receptor (NOP) antagonists have been shown to prevent...

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Veröffentlicht in:	Fundamental & clinical pharmacology 2016-12, Vol.30 (6), p.537-548
Hauptverfasser:	Ulugol, Ahmet, Topuz, Ruhan D., Gunduz, Ozgur, Kizilay, Gulnur, Karadag, Hakan C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminoquinolines - pharmacology Analgesics - pharmacology Analgesics, Opioid - pharmacology Animals antinociceptive effect Benzamides - pharmacology Benzoxazines - pharmacology Brain - drug effects Brain - metabolism cannabinoid Cannabinoids - pharmacology Drug Tolerance - physiology immunohistochemistry Male Morphine - pharmacology Morpholines - pharmacology Naphthalenes - pharmacology Narcotic Antagonists - pharmacology Nociceptin nociceptin/orphanin FQ Opioid Peptides - metabolism Pain - drug therapy Pain Measurement - methods Rats Rats, Sprague-Dawley Receptors, Opioid - metabolism tolerance Western blotting
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