Abstract 4877: Discovery of novel and potent inhibitors of indoleamine-2,3-dioxygenase (IDO1) for cancer immunotherapy

Indoleamine-2,3-dioxygenase (IDO1) is an immune regulatory enzyme that oxidizes tryptophan to kynurenine. IDO1 is overexpressed in numerous tumor cells that block T-cell activation, induce T-cell apoptosis and increase regulatory T cells, which create an environment in which tumor-specific cytotoxic...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2016-07, Vol.76 (14_Supplement), p.4877-4877
Hauptverfasser:	Liu, Shengyang, Tao, Taoliangshan, Liang, Yue, Guo, Hongli, Ye, Xiaogang, Wu, Zhiheng, Bao, Fang, Yang, Heping, Cai, Yaxian, Yang, Gangjing, Wang, Longsheng, Liu, Fang, Fu, Guangliang, Liu, Xiaolei, Du, Jiangang, Qin, Ping, Ma, Yuanfei, Zhu, Panhu, Yu, Yajun, Ma, Chen, Wang, Pei, Zhao, Liping, Wang, Yuxun, Gao, Daxin, Li, Qun
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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