Serum IgE specific to indoor moulds, measured by basophil histamine release, is associated with building-related symptoms in damp buildings
To study the relationship between basophil histamine release (HRT) to indoor moulds, indicating specific IgE, and building-related symptoms (BRS), asthma, and hay fever in individuals working in damp and mouldy buildings. A cross-sectional study was performed among 86 school staff members, who on av...
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| Veröffentlicht in: | Inflammation research 2001-04, Vol.50 (4), p.227-231 |
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| creator | Lander, F Meyer, H W Norn, S |
| description | To study the relationship between basophil histamine release (HRT) to indoor moulds, indicating specific IgE, and building-related symptoms (BRS), asthma, and hay fever in individuals working in damp and mouldy buildings.
A cross-sectional study was performed among 86 school staff members, who on average had worked 143 months (range: 3-396) in moist buildings with mould growth in the constructions. A questionnaire concerning mucous membrane symptoms, facial skin symptoms, central nervous system symptoms, hay fever, and asthma was fulfilled by the participants, and blood samples were taken. Eight mould species growing on building constructions were identified and cultivated to obtain allergenic materials for testing. The presence in serum of IgE specific to moulds was verified by histamine release test (HRT) based on passive sensitization of basophil leukocytes. The validity of the method was confirmed by parallel testing of patients allergic to grass- and birch pollen and by the shift from positive to negative response after removal of serum IgE and by using sham sensitization.
The prevalence of most BRS was between 32% and 62%. Positive HRT, showing serum IgE specific to one or more of the moulds, was observed in 37% of the individuals. The highest frequency of positive HRT was found to Penicillium chrysogenum and then to Aspergillus species, Cladosporium sphaerospermum and Stachybotrys chartarum. A significant association was found between most BRS and positive HRT, whereas no association was observed between positive HRT to moulds and self reported hay fever or asthma.
Positive HRT to indoor moulds, showing the presence in serum of IgE specific to the fungi, was found to be related to BRS in individuals working in damp and mouldy buildings. Whether the association is of causal character is a question for further studies. The test may be useful in the evaluation and study of possible mould induced BRS. |
| doi_str_mv | 10.1007/s000110050748 |
| format | Article |
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A cross-sectional study was performed among 86 school staff members, who on average had worked 143 months (range: 3-396) in moist buildings with mould growth in the constructions. A questionnaire concerning mucous membrane symptoms, facial skin symptoms, central nervous system symptoms, hay fever, and asthma was fulfilled by the participants, and blood samples were taken. Eight mould species growing on building constructions were identified and cultivated to obtain allergenic materials for testing. The presence in serum of IgE specific to moulds was verified by histamine release test (HRT) based on passive sensitization of basophil leukocytes. The validity of the method was confirmed by parallel testing of patients allergic to grass- and birch pollen and by the shift from positive to negative response after removal of serum IgE and by using sham sensitization.
The prevalence of most BRS was between 32% and 62%. Positive HRT, showing serum IgE specific to one or more of the moulds, was observed in 37% of the individuals. The highest frequency of positive HRT was found to Penicillium chrysogenum and then to Aspergillus species, Cladosporium sphaerospermum and Stachybotrys chartarum. A significant association was found between most BRS and positive HRT, whereas no association was observed between positive HRT to moulds and self reported hay fever or asthma.
Positive HRT to indoor moulds, showing the presence in serum of IgE specific to the fungi, was found to be related to BRS in individuals working in damp and mouldy buildings. Whether the association is of causal character is a question for further studies. The test may be useful in the evaluation and study of possible mould induced BRS.</description><identifier>ISSN: 1023-3830</identifier><identifier>EISSN: 1420-908X</identifier><identifier>DOI: 10.1007/s000110050748</identifier><identifier>PMID: 11392611</identifier><language>eng</language><publisher>Switzerland</publisher><subject>Adult ; Antibody Specificity ; Antigens, Fungal - immunology ; Aspergillus ; Aspergillus - immunology ; Asthma - immunology ; Basophils - physiology ; Cladosporium - immunology ; Cladosporium sphaerospermum ; Female ; histamine ; Histamine Release ; Humans ; Immunoglobulin E - blood ; Immunoglobulin E - immunology ; Male ; Middle Aged ; molds ; Penicillium chrysogenum ; Penicillium chrysogenum - immunology ; Rhinitis, Allergic, Seasonal - immunology ; schools ; Sick Building Syndrome - immunology ; Sick Building Syndrome - microbiology ; Stachybotrys - immunology ; Stachybotrys chartarum</subject><ispartof>Inflammation research, 2001-04, Vol.50 (4), p.227-231</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c353t-9516b67c2d8626782aa045e65316802ea96c673a9d734a6ea74467c679c801e53</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11392611$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lander, F</creatorcontrib><creatorcontrib>Meyer, H W</creatorcontrib><creatorcontrib>Norn, S</creatorcontrib><title>Serum IgE specific to indoor moulds, measured by basophil histamine release, is associated with building-related symptoms in damp buildings</title><title>Inflammation research</title><addtitle>Inflamm Res</addtitle><description>To study the relationship between basophil histamine release (HRT) to indoor moulds, indicating specific IgE, and building-related symptoms (BRS), asthma, and hay fever in individuals working in damp and mouldy buildings.
A cross-sectional study was performed among 86 school staff members, who on average had worked 143 months (range: 3-396) in moist buildings with mould growth in the constructions. A questionnaire concerning mucous membrane symptoms, facial skin symptoms, central nervous system symptoms, hay fever, and asthma was fulfilled by the participants, and blood samples were taken. Eight mould species growing on building constructions were identified and cultivated to obtain allergenic materials for testing. The presence in serum of IgE specific to moulds was verified by histamine release test (HRT) based on passive sensitization of basophil leukocytes. The validity of the method was confirmed by parallel testing of patients allergic to grass- and birch pollen and by the shift from positive to negative response after removal of serum IgE and by using sham sensitization.
The prevalence of most BRS was between 32% and 62%. Positive HRT, showing serum IgE specific to one or more of the moulds, was observed in 37% of the individuals. The highest frequency of positive HRT was found to Penicillium chrysogenum and then to Aspergillus species, Cladosporium sphaerospermum and Stachybotrys chartarum. A significant association was found between most BRS and positive HRT, whereas no association was observed between positive HRT to moulds and self reported hay fever or asthma.
Positive HRT to indoor moulds, showing the presence in serum of IgE specific to the fungi, was found to be related to BRS in individuals working in damp and mouldy buildings. Whether the association is of causal character is a question for further studies. The test may be useful in the evaluation and study of possible mould induced BRS.</description><subject>Adult</subject><subject>Antibody Specificity</subject><subject>Antigens, Fungal - immunology</subject><subject>Aspergillus</subject><subject>Aspergillus - immunology</subject><subject>Asthma - immunology</subject><subject>Basophils - physiology</subject><subject>Cladosporium - immunology</subject><subject>Cladosporium sphaerospermum</subject><subject>Female</subject><subject>histamine</subject><subject>Histamine Release</subject><subject>Humans</subject><subject>Immunoglobulin E - blood</subject><subject>Immunoglobulin E - immunology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>molds</subject><subject>Penicillium chrysogenum</subject><subject>Penicillium chrysogenum - immunology</subject><subject>Rhinitis, Allergic, Seasonal - immunology</subject><subject>schools</subject><subject>Sick Building Syndrome - immunology</subject><subject>Sick Building Syndrome - microbiology</subject><subject>Stachybotrys - immunology</subject><subject>Stachybotrys chartarum</subject><issn>1023-3830</issn><issn>1420-908X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90UtLJDEQB_AgK76Pe11yWvZga16dpI-L-ALBgwremnS6xsnSmfSmupH5DPuljTooe_FURfGjCupPyHfOTjhj5hQZY7x0NTPKbpE9rgSrGmYfv5WeCVlJK9ku2Uf8U6QVVuyQXc5lIzTne-TfHeQ50uunc4oj-LAInk6JhlWfUqYxzUOPxzSCwzlDT7s17RymcRkGugw4uRhWQDMMBcAxDUgdYvLBTQU_h2lJuzkMfVg9VQW9TXEdxylFLDdo7-L4IfCQbC_cgHC0qQfk4eL8_uyqurm9vD77fVN5WcupamquO2286K0W2ljhHFM16FpybZkA12ivjXRNb6RyGpxRqnBtGm8Zh1oekF_ve8ec_s6AUxsDehgGt4I0Y8ut0qo81dhCf35NjbWNUU2B1Tv0OSFmWLRjDtHldctZ-xpU-19Qxf_YLJ67CP2n3iQjXwDS4o5S</recordid><startdate>20010401</startdate><enddate>20010401</enddate><creator>Lander, F</creator><creator>Meyer, H W</creator><creator>Norn, S</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T2</scope><scope>7T5</scope><scope>7U2</scope><scope>C1K</scope><scope>H94</scope></search><sort><creationdate>20010401</creationdate><title>Serum IgE specific to indoor moulds, measured by basophil histamine release, is associated with building-related symptoms in damp buildings</title><author>Lander, F ; Meyer, H W ; Norn, S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c353t-9516b67c2d8626782aa045e65316802ea96c673a9d734a6ea74467c679c801e53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adult</topic><topic>Antibody Specificity</topic><topic>Antigens, Fungal - immunology</topic><topic>Aspergillus</topic><topic>Aspergillus - immunology</topic><topic>Asthma - immunology</topic><topic>Basophils - physiology</topic><topic>Cladosporium - immunology</topic><topic>Cladosporium sphaerospermum</topic><topic>Female</topic><topic>histamine</topic><topic>Histamine Release</topic><topic>Humans</topic><topic>Immunoglobulin E - blood</topic><topic>Immunoglobulin E - immunology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>molds</topic><topic>Penicillium chrysogenum</topic><topic>Penicillium chrysogenum - immunology</topic><topic>Rhinitis, Allergic, Seasonal - immunology</topic><topic>schools</topic><topic>Sick Building Syndrome - immunology</topic><topic>Sick Building Syndrome - microbiology</topic><topic>Stachybotrys - immunology</topic><topic>Stachybotrys chartarum</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lander, F</creatorcontrib><creatorcontrib>Meyer, H W</creatorcontrib><creatorcontrib>Norn, S</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Safety Science and Risk</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Inflammation research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lander, F</au><au>Meyer, H W</au><au>Norn, S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum IgE specific to indoor moulds, measured by basophil histamine release, is associated with building-related symptoms in damp buildings</atitle><jtitle>Inflammation research</jtitle><addtitle>Inflamm Res</addtitle><date>2001-04-01</date><risdate>2001</risdate><volume>50</volume><issue>4</issue><spage>227</spage><epage>231</epage><pages>227-231</pages><issn>1023-3830</issn><eissn>1420-908X</eissn><abstract>To study the relationship between basophil histamine release (HRT) to indoor moulds, indicating specific IgE, and building-related symptoms (BRS), asthma, and hay fever in individuals working in damp and mouldy buildings.
A cross-sectional study was performed among 86 school staff members, who on average had worked 143 months (range: 3-396) in moist buildings with mould growth in the constructions. A questionnaire concerning mucous membrane symptoms, facial skin symptoms, central nervous system symptoms, hay fever, and asthma was fulfilled by the participants, and blood samples were taken. Eight mould species growing on building constructions were identified and cultivated to obtain allergenic materials for testing. The presence in serum of IgE specific to moulds was verified by histamine release test (HRT) based on passive sensitization of basophil leukocytes. The validity of the method was confirmed by parallel testing of patients allergic to grass- and birch pollen and by the shift from positive to negative response after removal of serum IgE and by using sham sensitization.
The prevalence of most BRS was between 32% and 62%. Positive HRT, showing serum IgE specific to one or more of the moulds, was observed in 37% of the individuals. The highest frequency of positive HRT was found to Penicillium chrysogenum and then to Aspergillus species, Cladosporium sphaerospermum and Stachybotrys chartarum. A significant association was found between most BRS and positive HRT, whereas no association was observed between positive HRT to moulds and self reported hay fever or asthma.
Positive HRT to indoor moulds, showing the presence in serum of IgE specific to the fungi, was found to be related to BRS in individuals working in damp and mouldy buildings. Whether the association is of causal character is a question for further studies. The test may be useful in the evaluation and study of possible mould induced BRS.</abstract><cop>Switzerland</cop><pmid>11392611</pmid><doi>10.1007/s000110050748</doi><tpages>5</tpages></addata></record> |
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| subjects | Adult Antibody Specificity Antigens, Fungal - immunology Aspergillus Aspergillus - immunology Asthma - immunology Basophils - physiology Cladosporium - immunology Cladosporium sphaerospermum Female histamine Histamine Release Humans Immunoglobulin E - blood Immunoglobulin E - immunology Male Middle Aged molds Penicillium chrysogenum Penicillium chrysogenum - immunology Rhinitis, Allergic, Seasonal - immunology schools Sick Building Syndrome - immunology Sick Building Syndrome - microbiology Stachybotrys - immunology Stachybotrys chartarum |
| title | Serum IgE specific to indoor moulds, measured by basophil histamine release, is associated with building-related symptoms in damp buildings |
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