Positive Feedback Loop of OCT4 and c‐JUN Expedites Cancer Stemness in Liver Cancer

The network of stemness genes and oncogenes in human patient‐specific reprogrammed cancer stem cells (CSCs) remains elusive, especially in liver cancer. HepG2‐derived induced pluripotent stem cell‐like cells (HepG2‐iPS‐like cells) were generated by introducing Yamanaka factors and the knockdown vect...

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Veröffentlicht in:	Stem cells (Dayton, Ohio) Ohio), 2016-11, Vol.34 (11), p.2613-2624
Hauptverfasser:	Kuo, Kung‐Kai, Lee, King‐Teh, Chen, Ker‐Kong, Yang, Ya‐Han, Lin, Ying‐Chu, Tsai, Ming‐Ho, Wuputra, Kenly, Lee, Yen‐Liang, Ku, Chia‐Chen, Miyoshi, Hiroyuki, Nakamura, Yukio, Saito, Shigeo, Wu, Chun‐Chieh, Chai, Chee‐Yin, Eckner, Richard, Steve Lin, Chen‐Lung, Wang, Sophie S‐W, Wu, Deng‐Chyang, Lin, Chang‐Shen, Yokoyama, Kazunari K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Animals Antineoplastic Agents - pharmacology c-Jun protein c-Myc protein Cancer Cancer stem cells Cell Differentiation Cell fate Cellular Reprogramming Chemoresistance Cisplatin - pharmacology Colonies c‐JUN Doxorubicin - pharmacology Drug Resistance, Neoplasm - genetics Feedback Feedback loops Feedback, Physiological Female Fluorouracil - pharmacology Gene expression Gene Expression Regulation, Neoplastic Hep G2 Cells Hepatocytes Humans Induced Pluripotent Stem Cells - drug effects Induced Pluripotent Stem Cells - metabolism Induced Pluripotent Stem Cells - pathology JNK Mitogen-Activated Protein Kinases - genetics JNK Mitogen-Activated Protein Kinases - metabolism Liver Liver cancer Liver Neoplasms - drug therapy Liver Neoplasms - genetics Liver Neoplasms - metabolism Liver Neoplasms - pathology Male Mice Mice, SCID Middle Aged Myc protein Neoplastic Stem Cells - drug effects Neoplastic Stem Cells - metabolism Neoplastic Stem Cells - pathology Oct-4 protein OCT4 Octamer Transcription Factor-3 - genetics Octamer Transcription Factor-3 - metabolism Pluripotency Positive feedback Reprogramming Signal Transduction Spheroids, Cellular - drug effects Spheroids, Cellular - metabolism Spheroids, Cellular - pathology Stem cell transplantation Stem cells Transcription factors Transcriptional Activation Transplantation Tumor Burden - drug effects Tumor markers Tumorigenesis Tumors Xenograft Model Antitumor Assays Xenografts
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