Tyrosine kinase 2 is not limiting human antiviral type III interferon responses

Tyrosine kinase 2 (TYK2) associates with interferon (IFN) alpha receptor, IL‐10 receptor (IL‐10R) beta and other cytokine receptor subunits for signal transduction, in response to various cytokines, including type‐I and type‐III IFNs, IL‐6, IL‐10, IL‐12 and IL‐23. Data on TYK2 dependence on cytokine...

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Veröffentlicht in:	European journal of immunology 2016-11, Vol.46 (11), p.2639-2649
Hauptverfasser:	Fuchs, Sebastian, Kaiser‐Labusch, Petra, Bank, Julia, Ammann, Sandra, Kolb‐Kokocinski, Anja, Edelbusch, Christine, Omran, Heymut, Ehl, Stephan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line Child Disease Susceptibility - immunology Disease Susceptibility - virology Eczema - etiology Eczema - immunology HAP1 cells · IFN‐lambda · Immunodeficiencies · NK cells · TYK2 · VSV‐GFP Humans Immunoglobulin E - blood Interferon-gamma - immunology Interferon-gamma - metabolism Interferons - immunology Interleukin-10 - genetics Interleukin-10 - immunology Interleukin-6 - genetics Interleukin-6 - immunology Job Syndrome - immunology Killer Cells, Natural - immunology Mice Mutation Mycobacterium Receptors, Cytokine - immunology Receptors, Interleukin-10 - genetics Receptors, Interleukin-10 - immunology Signal Transduction - immunology Skin - pathology TYK2 Kinase - deficiency TYK2 Kinase - genetics TYK2 Kinase - immunology TYK2 Kinase - metabolism
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