Clinicopathological effects of protein phosphatase 2, regulatory subunit A, alpha mutations in gastrointestinal stromal tumors

Recently, several studies have reported that dysfunctions in protein phosphatase 2A (PP2A) caused by alterations in protein phosphatase 2 regulatory subunit A, alpha (PPP2R1A) are responsible for tumorigenesis and tumor progression in several types of cancers. The impact of PPP2R1A mutations remains...

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Veröffentlicht in:	Modern pathology 2016-11, Vol.29 (11), p.1424-1432
Hauptverfasser:	Toda-Ishii, Midori, Akaike, Keisuke, Suehara, Yoshiyuki, Mukaihara, Kenta, Kubota, Daisuke, Kohsaka, Shinji, Okubo, Taketo, Mitani, Keiko, Mogushi, Kaoru, Takagi, Tatsuya, Kaneko, Kazuo, Yao, Takashi, Saito, Tsuyoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 13/109 38/23 38/70 631/67/1504/1829 631/67/69 Aged Angiogenesis Cell cycle Dehydrogenases Disease-Free Survival DNA Mutational Analysis Female Gastrointestinal Stromal Tumors - genetics Gastrointestinal Stromal Tumors - mortality Humans Kinases Laboratory Medicine Male Medical prognosis Medicine Medicine & Public Health Middle Aged Mutation original-article Pathology Phosphatase Phosphorylation Prognosis Protein Phosphatase 2 - genetics Proteins Signal transduction Tumorigenesis Tumors
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