Coumarin-Induced DNA Ligation, Rearrangement to DNA Interstrand Crosslinks, and Photorelease of Coumarin Moiety

Coumarin moieties react with thymine and cytosine in DNA by photoinduced [2+2] cycloaddition, which allows quantitative DNA interstrand crosslink (ICL) formation. Here, we report the application of coumarin analogues for DNA photoligation and the rearrangement of coumarin‐induced ligation to ICL pro...

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Veröffentlicht in:	Chembiochem : a European journal of chemical biology 2016-11, Vol.17 (21), p.2046-2053
Hauptverfasser:	Sun, Huabing, Fan, Heli, Eom, Hyeyoung, Peng, Xiaohua
Format:	Artikel
Sprache:	eng
Schlagworte:	coumarins Coumarins - chemistry Coumarins - pharmacology Cross-Linking Reagents - chemistry Deoxyribonucleic acid DNA DNA - chemistry DNA - drug effects DNA rearrangement Humans interstrand crosslink Molecular Structure Photochemical Processes photoligation photorelease
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