Endotoxin-induced acute lung injury in mice is protected by 5,7-dihydroxy-8-methoxyflavone via inhibition of oxidative stress and HIF-1α

ABSTRACT Up to date, the morbidity and mortality rates of acute lung injury (ALI) still rank high among clinical illnesses. Endotoxin, also called lipopolysaccharide (LPS), induced sepsis is the major cause for ALI. Beneficial biological effects, such as antioxidation, anti‐inflammation, and neuropr...

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Veröffentlicht in:	Environmental toxicology 2016-12, Vol.31 (12), p.1700-1709
Hauptverfasser:	Sun, Hai-Lun, Peng, Mei-Ling, Lee, Shiuan-Shinn, Chen, Chun-Jung, Chen, Wen-Ying, Yang, Ming-Ling, Kuan, Yu-Hsiang
Format:	Artikel
Sprache:	eng
Schlagworte:	5,7‐dihydroxy‐8‐methoxyflavone (DHMF) 7-dihydroxy-8-methoxyflavone (DHMF) acute lung injury Acute Lung Injury - metabolism Acute Lung Injury - prevention & control Animals antioxidative enzymes Catalase - metabolism endotoxin Flavanones - pharmacology Flavanones - therapeutic use Glutathione Peroxidase - metabolism HIF-1α Hypoxia-Inducible Factor 1, alpha Subunit - antagonists & inhibitors Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Interleukin-1beta - metabolism Lipid Peroxidation Lipopolysaccharides - pharmacology Lung - drug effects Lung - pathology Male Mice, Inbred ICR Neuroprotective Agents - pharmacology Neuroprotective Agents - therapeutic use NF-kappa B - metabolism Oxidative Stress - drug effects Superoxide Dismutase - metabolism Tumor Necrosis Factor-alpha - metabolism Up-Regulation
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