Recombinant AAV-mediated in vivo long-term expression and antitumour activity of an anti-ganglioside GM3(Neu5Gc) antibody

The ganglioside GM3(Neu5Gc) has gained increasing attention as therapeutic target because of its selective expression in various human tumours, such as melanoma, breast and lung cancer. 14F7 is a mouse IgG1 with specific reactivity to GM3(Neu5Gc)-positive tumours. The therapeutic activity of 14F7 ha...

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Veröffentlicht in:	Gene therapy 2015-12, Vol.22 (12), p.960-967
Hauptverfasser:	Piperno, G M, López-Requena, A, Predonzani, A, Dorvignit, D, Labrada, M, Zentilin, L, Burrone, O R, Cesco-Gaspere, M
Format:	Artikel
Sprache:	eng
Schlagworte:	42 42/44 631/1647/1511 631/1647/2300/1850 631/250/251 631/61/2300/1514 631/67/1059/99 Amino Acid Sequence Animals Antibodies Antibodies, Monoclonal - biosynthesis Antibodies, Monoclonal - immunology Biomedical and Life Sciences Biomedicine Breast Breast cancer Cancer Care and treatment Cell Biology Dependovirus - genetics Dependovirus - metabolism G(M3) Ganglioside - immunology Ganglioside GM3 Gangliosides Gene Expression Gene Therapy Genetic aspects Health aspects HEK293 Cells Human Genetics Humans Immunoglobulin G Immunoglobulin G - biosynthesis Immunoglobulin G - immunology Lung cancer Melanoma Mice Mice, Inbred BALB C Molecular Sequence Data Monoclonal antibodies Myeloma Nanotechnology Neoplasms, Experimental - immunology Neoplasms, Experimental - therapy original-article Recombinant Proteins - genetics Recombinant Proteins - metabolism Therapeutic applications Tumors
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