Synergistic effect of rSAG1 and rGRA2 antigens formulated in PLGA microspheres in eliciting immune protection against Toxoplasama gondii

There is still no human vaccine against Toxoplasma gondii (T. gondii), as one of the most successful parasites. In present study, we designed a subunit vaccine composed of recombinant SAG1 (rSAG1) and recombinant GRA2 (rGRA2) proteins. In order to improve the induced immune responses, rSAG1 and rGRA...

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Veröffentlicht in:	Experimental parasitology 2016-11, Vol.170, p.236-246
Hauptverfasser:	Allahyari, Mojgan, Mohabati, Reyhaneh, Amiri, Samira, Esmaeili Rastaghi, Ahmad Reza, Babaie, Jalal, Mahdavi, Mehdi, Vatanara, Alireza, Golkar, Majid
Format:	Artikel
Sprache:	eng
Schlagworte:	Adsorption Animals Antigens, Protozoan - administration & dosage Antigens, Protozoan - immunology Drug Carriers Drug Synergism Female Humans Immunoglobulin G - blood Interferon-gamma - analysis Interleukin-10 - analysis Lactic Acid Mice Mice, Inbred BALB C Microspheres PLGA microspheres Polyglycolic Acid Pregnancy Protozoan Proteins - administration & dosage Protozoan Proteins - immunology Protozoan Vaccines - administration & dosage Protozoan Vaccines - immunology Rabbits Random Allocation Recombinant Proteins - administration & dosage Recombinant Proteins - immunology rGRA2 rSAG1 Spleen - cytology Spleen - immunology Toxoplasama gondii Toxoplasma - immunology Toxoplasma gondii Toxoplasmosis, Animal - prevention & control Vaccine Vaccines, Subunit - immunology
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