Protein cysteine S-nitrosylation inhibits vesicular uptake of neurotransmitters

Highlights • Nitric oxide induces nitrosylation of vesicular monoamine transporter 2. • Nitric oxide induces nitrosylation of vesicular acetylcholine transporter. • Nitric oxide induces nitrosylation of vesicular glutamate transporters 1 and 2. • Nitric oxide inhibits the vesicular uptake of neurotr...

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Veröffentlicht in:	Neuroscience 2015-12, Vol.311, p.374-381
Hauptverfasser:	Wang, Y, Zhou, Z, Leylek, T, Tan, H, Sun, Y, Parkinson, F.E, Wang, J.-F
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - metabolism Animals Brain - drug effects Brain - metabolism Dopamine - metabolism Glutamic Acid - metabolism Mice Neurology neurotransmitter uptake nitric oxide Nitric Oxide - metabolism Nitric Oxide Donors - pharmacology nitrosylation S-Nitrosoglutathione - analogs & derivatives S-Nitrosoglutathione - pharmacology Tritium Vesicular Acetylcholine Transport Proteins - metabolism Vesicular Glutamate Transport Protein 1 - metabolism Vesicular Glutamate Transport Protein 2 - metabolism Vesicular Monoamine Transport Proteins - metabolism vesicular neurotransmitter transporters
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Zusammenfassung:	Highlights • Nitric oxide induces nitrosylation of vesicular monoamine transporter 2. • Nitric oxide induces nitrosylation of vesicular acetylcholine transporter. • Nitric oxide induces nitrosylation of vesicular glutamate transporters 1 and 2. • Nitric oxide inhibits the vesicular uptake of neurotransmitters.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2015.10.052