Dual antiplasmodial activity of vitamin D3 and its analog, 22-oxacalcitriol, by direct and indirect mechanisms

Abstract Recent evidence suggests that 1α,25-dihydroxyvitamin D3 (calcitriol, VD3), the active form of vitamin D (VD), can inhibit the proliferation of microorganisms. In the present study, we conducted in vitro experiments and utilized in vivo murine models to investigate the antimalarial activity...

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Veröffentlicht in:	Parasitology international 2017-04, Vol.66 (2), p.89-99
Hauptverfasser:	Yamamoto, Kiichi, Iwagami, Moritoshi, Seki, Takenori, Kano, Shigeyuki, Ota, Nobuo, Ato, Manabu
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease - therapy Animals Antimalarials - pharmacology Antimalarials - therapeutic use Body Weight - drug effects Calcitriol - analogs & derivatives Calcitriol - pharmacology Calcitriol - therapeutic use Cholecalciferol - administration & dosage Cholecalciferol - pharmacology Chronic Disease - drug therapy Diphosphonates - pharmacology Diphosphonates - therapeutic use Erythrocytes - drug effects Erythrocytes - parasitology Gastroenterology and Hepatology Humans Hypercalcemia - blood Hypercalcemia - drug therapy Imidazoles - pharmacology Imidazoles - therapeutic use Infectious Disease Interferon-gamma - blood Interferon-gamma - deficiency Malaria - drug therapy Malaria - parasitology Mice Mice, Inbred BALB C Mice, Knockout Parasitemia - drug therapy Parasitemia - immunology Parasitemia - parasitology Plasmodium chabaudi - drug effects Plasmodium chabaudi - growth & development Plasmodium chabaudi - immunology Receptors, Calcitriol - deficiency
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