Effect of hyperthyroidism on circulating prolactin and hypothalamic expression of tyrosine hydroxylase, prolactin signaling cascade members and estrogen and progesterone receptors during late pregnancy and lactation in the rat

Hyperthyroidism (HyperT) compromises pregnancy and lactation, hindering suckling-induced PRL release. We studied the effect of HyperT on hypothalamic mRNA (RT-qPCR) and protein (Western blot) expression of tyrosine hydroxylase (TH), PRL receptor (PRLR) and signaling pathway members, estrogen-α (ERα)...

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Veröffentlicht in:	Molecular and cellular endocrinology 2017-02, Vol.442, p.40-50
Hauptverfasser:	Pennacchio, Gisela E., Neira, Flavia J., Soaje, Marta, Jahn, Graciela A., Valdez, Susana R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Breast Feeding - methods Dopamine - metabolism Estrogens - metabolism Female Hyperthyroidism Hyperthyroidism - pathology Hypothalamic dopaminergic neurons Hypothalamus - metabolism Lactation Lactation - metabolism Mammary Glands, Animal - metabolism Pregnancy Pregnancy Complications - metabolism Pregnancy, Animal - metabolism PRL PRL signaling pathway Progesterone - metabolism Prolactin - metabolism Rats Rats, Wistar Receptors, Estrogen - metabolism Receptors, Progesterone - metabolism Receptors, Prolactin - metabolism RNA, Messenger - metabolism Signal Transduction - physiology Tyrosine 3-Monooxygenase - metabolism Tyrosine hydroxylase
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