Reduced cortical thickness in body dysmorphic disorder

Abstract Recent neuroimaging studies in body dysmorphic disorder (BDD) have implicated abnormal structure and function of occipito-temporal and fronto-limbic regions in the potential pathophysiology of the disorder. To date, morphometric investigations have yielded inconsistent results, and have sug...

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Veröffentlicht in:Psychiatry research. Neuroimaging 2017-01, Vol.259, p.25-28
Hauptverfasser: Grace, Sally A, Ben Buchanan, Maller, Jerome J, Toh, Wei Lin, Castle, David J, Rossell, Susan L
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container_start_page 25
container_title Psychiatry research. Neuroimaging
container_volume 259
creator Grace, Sally A
Ben Buchanan
Maller, Jerome J
Toh, Wei Lin
Castle, David J
Rossell, Susan L
description Abstract Recent neuroimaging studies in body dysmorphic disorder (BDD) have implicated abnormal structure and function of occipito-temporal and fronto-limbic regions in the potential pathophysiology of the disorder. To date, morphometric investigations have yielded inconsistent results, and have suggested that clinical symptoms may mediate morphometric abnormalities in BDD. We measured Grey Matter (GM) cortical thickness in 20 participants with BDD and 20 healthy control participants matched on age, gender and handedness. We observed cortical thinning in BDD patients compared with healthy control participants within the left middle temporal and left inferior parietal gyrus. No significant relationships between cortical thickness and BDD symptom severity, insight, social anxiety and depression were observed within the BDD group. Thinning within left temporal and left inferior parietal regions supports the involvement of these regions in the pathophysiology of BDD.
doi_str_mv 10.1016/j.pscychresns.2016.11.004
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subjects Adult
Body Dysmorphic Disorders - diagnostic imaging
Body Dysmorphic Disorders - pathology
Cerebral cortex
Cerebral Cortex - diagnostic imaging
Cerebral Cortex - pathology
Female
Functional Laterality - physiology
Grey matter
Humans
Magnetic resonance imaging
Magnetic Resonance Imaging - methods
Male
Middle Aged
Organ Size - physiology
Psychiatry
Radiology
Young Adult
title Reduced cortical thickness in body dysmorphic disorder
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