Reduced cortical thickness in body dysmorphic disorder
Abstract Recent neuroimaging studies in body dysmorphic disorder (BDD) have implicated abnormal structure and function of occipito-temporal and fronto-limbic regions in the potential pathophysiology of the disorder. To date, morphometric investigations have yielded inconsistent results, and have sug...
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creator | Grace, Sally A Ben Buchanan Maller, Jerome J Toh, Wei Lin Castle, David J Rossell, Susan L |
description | Abstract Recent neuroimaging studies in body dysmorphic disorder (BDD) have implicated abnormal structure and function of occipito-temporal and fronto-limbic regions in the potential pathophysiology of the disorder. To date, morphometric investigations have yielded inconsistent results, and have suggested that clinical symptoms may mediate morphometric abnormalities in BDD. We measured Grey Matter (GM) cortical thickness in 20 participants with BDD and 20 healthy control participants matched on age, gender and handedness. We observed cortical thinning in BDD patients compared with healthy control participants within the left middle temporal and left inferior parietal gyrus. No significant relationships between cortical thickness and BDD symptom severity, insight, social anxiety and depression were observed within the BDD group. Thinning within left temporal and left inferior parietal regions supports the involvement of these regions in the pathophysiology of BDD. |
doi_str_mv | 10.1016/j.pscychresns.2016.11.004 |
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To date, morphometric investigations have yielded inconsistent results, and have suggested that clinical symptoms may mediate morphometric abnormalities in BDD. We measured Grey Matter (GM) cortical thickness in 20 participants with BDD and 20 healthy control participants matched on age, gender and handedness. We observed cortical thinning in BDD patients compared with healthy control participants within the left middle temporal and left inferior parietal gyrus. No significant relationships between cortical thickness and BDD symptom severity, insight, social anxiety and depression were observed within the BDD group. Thinning within left temporal and left inferior parietal regions supports the involvement of these regions in the pathophysiology of BDD.</description><identifier>ISSN: 0925-4927</identifier><identifier>EISSN: 1872-7506</identifier><identifier>DOI: 10.1016/j.pscychresns.2016.11.004</identifier><identifier>PMID: 27918913</identifier><language>eng</language><publisher>Netherlands: Elsevier Ireland Ltd</publisher><subject>Adult ; Body Dysmorphic Disorders - diagnostic imaging ; Body Dysmorphic Disorders - pathology ; Cerebral cortex ; Cerebral Cortex - diagnostic imaging ; Cerebral Cortex - pathology ; Female ; Functional Laterality - physiology ; Grey matter ; Humans ; Magnetic resonance imaging ; Magnetic Resonance Imaging - methods ; Male ; Middle Aged ; Organ Size - physiology ; Psychiatry ; Radiology ; Young Adult</subject><ispartof>Psychiatry research. Neuroimaging, 2017-01, Vol.259, p.25-28</ispartof><rights>2016 Elsevier Ireland Ltd</rights><rights>Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c432t-2593482e5d915656211047765dfb9223a59a8a888380c78266ba7a2ccab8ca033</citedby><cites>FETCH-LOGICAL-c432t-2593482e5d915656211047765dfb9223a59a8a888380c78266ba7a2ccab8ca033</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.pscychresns.2016.11.004$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27918913$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Grace, Sally A</creatorcontrib><creatorcontrib>Ben Buchanan</creatorcontrib><creatorcontrib>Maller, Jerome J</creatorcontrib><creatorcontrib>Toh, Wei Lin</creatorcontrib><creatorcontrib>Castle, David J</creatorcontrib><creatorcontrib>Rossell, Susan L</creatorcontrib><title>Reduced cortical thickness in body dysmorphic disorder</title><title>Psychiatry research. Neuroimaging</title><addtitle>Psychiatry Res Neuroimaging</addtitle><description>Abstract Recent neuroimaging studies in body dysmorphic disorder (BDD) have implicated abnormal structure and function of occipito-temporal and fronto-limbic regions in the potential pathophysiology of the disorder. To date, morphometric investigations have yielded inconsistent results, and have suggested that clinical symptoms may mediate morphometric abnormalities in BDD. We measured Grey Matter (GM) cortical thickness in 20 participants with BDD and 20 healthy control participants matched on age, gender and handedness. We observed cortical thinning in BDD patients compared with healthy control participants within the left middle temporal and left inferior parietal gyrus. No significant relationships between cortical thickness and BDD symptom severity, insight, social anxiety and depression were observed within the BDD group. Thinning within left temporal and left inferior parietal regions supports the involvement of these regions in the pathophysiology of BDD.</description><subject>Adult</subject><subject>Body Dysmorphic Disorders - diagnostic imaging</subject><subject>Body Dysmorphic Disorders - pathology</subject><subject>Cerebral cortex</subject><subject>Cerebral Cortex - diagnostic imaging</subject><subject>Cerebral Cortex - pathology</subject><subject>Female</subject><subject>Functional Laterality - physiology</subject><subject>Grey matter</subject><subject>Humans</subject><subject>Magnetic resonance imaging</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Organ Size - physiology</subject><subject>Psychiatry</subject><subject>Radiology</subject><subject>Young Adult</subject><issn>0925-4927</issn><issn>1872-7506</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc2LFDEQxYMo7rj6L0h789JtKulOJxdBhvUDFgQ_ziGd1LCZ7emMqW6h_3vTzCriyVPB41U96vcYewW8AQ7qzbE5k1_9XUaaqBFFagAazttHbAe6F3XfcfWY7bgRXd0a0V-xZ0RHzoXUSj5lV6I3oA3IHVNfMCweQ-VTnqN3YzXfRX8_IVEVp2pIYa3CSqeUz0WvQqSUA-bn7MnBjYQvHuY1-_7-5tv-Y337-cOn_bvb2rdSzLXojGy1wC4Y6FSnBABv-1514TAYIaTrjNNOay01970WSg2ud8J7N2jvuJTX7PXl7jmnHwvSbE-RPI6jmzAtZEG3SirFzWY1F6vPiSjjwZ5zPLm8WuB2w2aP9i9sdsNmAWzBVnZfPsQswwnDn83fnIphfzFgefZnxGzJR5wKuJjRzzak-F8xb_-54sc4bdTvcUU6piVPhaYFS8Jy-3Xrb6sPlOSCl-p-AYicmDU</recordid><startdate>20170130</startdate><enddate>20170130</enddate><creator>Grace, Sally A</creator><creator>Ben Buchanan</creator><creator>Maller, Jerome J</creator><creator>Toh, Wei Lin</creator><creator>Castle, David J</creator><creator>Rossell, Susan L</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20170130</creationdate><title>Reduced cortical thickness in body dysmorphic disorder</title><author>Grace, Sally A ; Ben Buchanan ; Maller, Jerome J ; Toh, Wei Lin ; Castle, David J ; Rossell, Susan L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c432t-2593482e5d915656211047765dfb9223a59a8a888380c78266ba7a2ccab8ca033</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Body Dysmorphic Disorders - diagnostic imaging</topic><topic>Body Dysmorphic Disorders - pathology</topic><topic>Cerebral cortex</topic><topic>Cerebral Cortex - diagnostic imaging</topic><topic>Cerebral Cortex - pathology</topic><topic>Female</topic><topic>Functional Laterality - physiology</topic><topic>Grey matter</topic><topic>Humans</topic><topic>Magnetic resonance imaging</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Organ Size - physiology</topic><topic>Psychiatry</topic><topic>Radiology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Grace, Sally A</creatorcontrib><creatorcontrib>Ben Buchanan</creatorcontrib><creatorcontrib>Maller, Jerome J</creatorcontrib><creatorcontrib>Toh, Wei Lin</creatorcontrib><creatorcontrib>Castle, David J</creatorcontrib><creatorcontrib>Rossell, Susan L</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Psychiatry research. Neuroimaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Grace, Sally A</au><au>Ben Buchanan</au><au>Maller, Jerome J</au><au>Toh, Wei Lin</au><au>Castle, David J</au><au>Rossell, Susan L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reduced cortical thickness in body dysmorphic disorder</atitle><jtitle>Psychiatry research. Neuroimaging</jtitle><addtitle>Psychiatry Res Neuroimaging</addtitle><date>2017-01-30</date><risdate>2017</risdate><volume>259</volume><spage>25</spage><epage>28</epage><pages>25-28</pages><issn>0925-4927</issn><eissn>1872-7506</eissn><abstract>Abstract Recent neuroimaging studies in body dysmorphic disorder (BDD) have implicated abnormal structure and function of occipito-temporal and fronto-limbic regions in the potential pathophysiology of the disorder. 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subjects | Adult Body Dysmorphic Disorders - diagnostic imaging Body Dysmorphic Disorders - pathology Cerebral cortex Cerebral Cortex - diagnostic imaging Cerebral Cortex - pathology Female Functional Laterality - physiology Grey matter Humans Magnetic resonance imaging Magnetic Resonance Imaging - methods Male Middle Aged Organ Size - physiology Psychiatry Radiology Young Adult |
title | Reduced cortical thickness in body dysmorphic disorder |
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