Piracetam and Vinpocetine Exert Cytoprotective Activity and Prevent Apoptosis of Astrocytes In Vitro in Hypoxia and Reoxygenation

The aim of the present study was to establish whether piracetam (2-pyrrolidon- N-acetamide; PIR) and vinpocetine (a vasoactive vinca alkaloid; VINP) are capable of protecting astrocytes against hypoxic injury. Using the model of astrocyte cell culture we observed the cells treated with PIR and VINP...

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Veröffentlicht in:	Neurotoxicology (Park Forest South) 2002-05, Vol.23 (1), p.19-31
Hauptverfasser:	Gabryel, Bożena, Adamek, Mariusz, Pudełko, Anna, Małecki, Andrzej, Trzeciak, Henryk I
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Apoptosis Apoptosis - drug effects Apoptosis - physiology Astrocytes Astrocytes - cytology Astrocytes - drug effects Astrocytes - physiology Biological and medical sciences Cell Death - drug effects Cell Death - physiology Cell Hypoxia - drug effects Cell Hypoxia - physiology Cells, Cultured Cytoprotection - drug effects Cytoprotection - physiology Hypoxia Medical sciences Neuropharmacology Neuroprotective agent Oxygen - metabolism Oxygen Consumption - drug effects Oxygen Consumption - physiology Pharmacology. Drug treatments Piracetam Piracetam - pharmacology Rats Rats, Wistar Reoxygenation Vinca Alkaloids - pharmacology Vinpocetine
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