Food, gastrointestinal pH, and models of oral drug absorption

[Display omitted] This article reviews the major physiological and physicochemical principles of the effect of food and gastrointestinal (GI) pH on the absorption and bioavailability of oral drugs, and the various absorption models that are used to describe/predict oral drug absorption. The rate and...

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Veröffentlicht in:	European journal of pharmaceutics and biopharmaceutics 2017-03, Vol.112, p.234-248
Hauptverfasser:	Abuhelwa, Ahmad Y., Williams, Desmond B., Upton, Richard N., Foster, David J.R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Aged Biological Availability Empirical absorption models Food-Drug Interactions Gastrointestinal pH Gastrointestinal Tract - metabolism Humans Hydrogen-Ion Concentration Pharmacokinetics Physiologically-based pharmacokinetic (PBPK) models Predicting oral absorption Solubility
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