Association of PDCD1 polymorphism to systemic lupus erythematosus and rheumatoid arthritis susceptibility
This study aims to analyze the relationship of programmed cell death 1 (PDCD1) gene polymorphism (PD1.3G/A – rs11568821) with features of systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) in a Southern Brazilian population. Polymerase chain reaction-restriction fragment length polymor...
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| creator | do Canto, Luisa Matos Farias, Ticiana Della Justina Medeiros, Mayara Delagnelo Coêlho, Cíntia Callegari Sereia, Aline Fernanda Rodrigues de Carlos Back, Lia Kubelka Fernandes de Mello, Filipe Martins Zimmermann, Adriana Fontes Pereira, Ivânio Alves de Souza, Ilíada Rainha |
| description | This study aims to analyze the relationship of programmed cell death 1 (PDCD1) gene polymorphism (PD1.3G/A – rs11568821) with features of systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) in a Southern Brazilian population.
Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was performed in 95 SLE and 87 RA patients and 128 control group individuals from Santa Catarina, Southern Brazil. The Hardy–Weinberg equilibrium (HWE) test, and odds ratio (OR) were analyzed, considering CI 95% and p≤0.05.
The PD1.3A allele frequencies were 0.095 (SLE), 0.115 (RA) and 0.078 (controls). The genotypes of the control group were in HWE, while those of SLE and RA patients were not. However, we found no association between PD1.3 polymorphism and the SLE or RA susceptibility, nor clinical or epidemiological data.
There was no significant association between PD1.3 polymorphism and SLE or RA susceptibility in this Southern Brazilian population.
Este estudo teve como objetivo analisar a relação entre o polimorfismo do gene PDCD1 (Programmed cell death 1) (PD1.3G/A – rs11568821) com caraterísticas do lúpus eritematoso sistêmico (LES) e da artrite reumatoide (AR) em uma população do sul do Brasil.
A técnica de PCR-RFLP (Polymerase Chain Reaction-Restriction Fragment Lenght Polymorphism) foi utilizada para analisar amostras de 95 pacientes com LES e 87 com AR e 128 indivíduos do grupo controle de Santa Catarina, sul do Brasil. Foi analisada a probabilidade de equilíbrio de Hardy–Weinberg (EHW) e o odds ratio (OR), considerando um IC 95% e p≤0.05.
As frequências alélicas PD1.3A foram de 0,095 (LES), 0,115 (AR) e 0,078 (controles). Os genótipos do grupo controle estavam em EHW, enquanto aqueles dos pacientes com LES e AR não estavam. No entanto, não foi encontrada nenhuma associação entre o polimorfismo PD1.3 e a susceptibilidade ao LES ou à AR, nem com dados clínicos ou epidemiológicos.
Não foi encontrada associação significativa entre o polimorfismo PD1.3 e a susceptibilidade ao LES ou à AR nesta população do sul do Brasil. |
| doi_str_mv | 10.1016/j.rbre.2015.07.008 |
| format | Article |
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Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was performed in 95 SLE and 87 RA patients and 128 control group individuals from Santa Catarina, Southern Brazil. The Hardy–Weinberg equilibrium (HWE) test, and odds ratio (OR) were analyzed, considering CI 95% and p≤0.05.
The PD1.3A allele frequencies were 0.095 (SLE), 0.115 (RA) and 0.078 (controls). The genotypes of the control group were in HWE, while those of SLE and RA patients were not. However, we found no association between PD1.3 polymorphism and the SLE or RA susceptibility, nor clinical or epidemiological data.
There was no significant association between PD1.3 polymorphism and SLE or RA susceptibility in this Southern Brazilian population.
Este estudo teve como objetivo analisar a relação entre o polimorfismo do gene PDCD1 (Programmed cell death 1) (PD1.3G/A – rs11568821) com caraterísticas do lúpus eritematoso sistêmico (LES) e da artrite reumatoide (AR) em uma população do sul do Brasil.
A técnica de PCR-RFLP (Polymerase Chain Reaction-Restriction Fragment Lenght Polymorphism) foi utilizada para analisar amostras de 95 pacientes com LES e 87 com AR e 128 indivíduos do grupo controle de Santa Catarina, sul do Brasil. Foi analisada a probabilidade de equilíbrio de Hardy–Weinberg (EHW) e o odds ratio (OR), considerando um IC 95% e p≤0.05.
As frequências alélicas PD1.3A foram de 0,095 (LES), 0,115 (AR) e 0,078 (controles). Os genótipos do grupo controle estavam em EHW, enquanto aqueles dos pacientes com LES e AR não estavam. No entanto, não foi encontrada nenhuma associação entre o polimorfismo PD1.3 e a susceptibilidade ao LES ou à AR, nem com dados clínicos ou epidemiológicos.
Não foi encontrada associação significativa entre o polimorfismo PD1.3 e a susceptibilidade ao LES ou à AR nesta população do sul do Brasil.</description><identifier>ISSN: 2255-5021</identifier><identifier>ISSN: 1809-4570</identifier><identifier>EISSN: 2255-5021</identifier><identifier>DOI: 10.1016/j.rbre.2015.07.008</identifier><identifier>PMID: 27914594</identifier><language>eng</language><publisher>Brazil: Elsevier Editora Ltda</publisher><subject>Apoptosis Regulatory Proteins - genetics ; Arthritis, Rheumatoid - genetics ; Artrite reumatoide ; Autoimmunity ; Autoimunidade ; Brazil ; Case-Control Studies ; Gene Frequency ; Gene PDCD1 ; Genetic Predisposition to Disease ; Humans ; Lupus Erythematosus, Systemic - genetics ; Lúpus eritematoso sistêmico ; PD1.3 polymorphism ; PDCD1 gene ; Polimorfismo PD1.3 ; Polymorphism, Restriction Fragment Length ; Programmed Cell Death 1 Receptor ; Rheumatoid arthritis ; Systemic lupus erythematosus</subject><ispartof>Revista Brasileira de Reumatologia, 2016-11, Vol.56 (6), p.483-489</ispartof><rights>2015 Elsevier Editora Ltda.</rights><rights>Copyright © 2015 Elsevier Editora Ltda. All rights reserved.</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c435t-fadaca2ec2c035d931614c51e80c62aa9cc3bb3d4346f357142c883a9e7dbf33</citedby><cites>FETCH-LOGICAL-c435t-fadaca2ec2c035d931614c51e80c62aa9cc3bb3d4346f357142c883a9e7dbf33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27914594$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>do Canto, Luisa Matos</creatorcontrib><creatorcontrib>Farias, Ticiana Della Justina</creatorcontrib><creatorcontrib>Medeiros, Mayara Delagnelo</creatorcontrib><creatorcontrib>Coêlho, Cíntia Callegari</creatorcontrib><creatorcontrib>Sereia, Aline Fernanda Rodrigues</creatorcontrib><creatorcontrib>de Carlos Back, Lia Kubelka Fernandes</creatorcontrib><creatorcontrib>de Mello, Filipe Martins</creatorcontrib><creatorcontrib>Zimmermann, Adriana Fontes</creatorcontrib><creatorcontrib>Pereira, Ivânio Alves</creatorcontrib><creatorcontrib>de Souza, Ilíada Rainha</creatorcontrib><title>Association of PDCD1 polymorphism to systemic lupus erythematosus and rheumatoid arthritis susceptibility</title><title>Revista Brasileira de Reumatologia</title><addtitle>Rev Bras Reumatol Engl Ed</addtitle><description>This study aims to analyze the relationship of programmed cell death 1 (PDCD1) gene polymorphism (PD1.3G/A – rs11568821) with features of systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) in a Southern Brazilian population.
Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was performed in 95 SLE and 87 RA patients and 128 control group individuals from Santa Catarina, Southern Brazil. The Hardy–Weinberg equilibrium (HWE) test, and odds ratio (OR) were analyzed, considering CI 95% and p≤0.05.
The PD1.3A allele frequencies were 0.095 (SLE), 0.115 (RA) and 0.078 (controls). The genotypes of the control group were in HWE, while those of SLE and RA patients were not. However, we found no association between PD1.3 polymorphism and the SLE or RA susceptibility, nor clinical or epidemiological data.
There was no significant association between PD1.3 polymorphism and SLE or RA susceptibility in this Southern Brazilian population.
Este estudo teve como objetivo analisar a relação entre o polimorfismo do gene PDCD1 (Programmed cell death 1) (PD1.3G/A – rs11568821) com caraterísticas do lúpus eritematoso sistêmico (LES) e da artrite reumatoide (AR) em uma população do sul do Brasil.
A técnica de PCR-RFLP (Polymerase Chain Reaction-Restriction Fragment Lenght Polymorphism) foi utilizada para analisar amostras de 95 pacientes com LES e 87 com AR e 128 indivíduos do grupo controle de Santa Catarina, sul do Brasil. Foi analisada a probabilidade de equilíbrio de Hardy–Weinberg (EHW) e o odds ratio (OR), considerando um IC 95% e p≤0.05.
As frequências alélicas PD1.3A foram de 0,095 (LES), 0,115 (AR) e 0,078 (controles). Os genótipos do grupo controle estavam em EHW, enquanto aqueles dos pacientes com LES e AR não estavam. No entanto, não foi encontrada nenhuma associação entre o polimorfismo PD1.3 e a susceptibilidade ao LES ou à AR, nem com dados clínicos ou epidemiológicos.
Não foi encontrada associação significativa entre o polimorfismo PD1.3 e a susceptibilidade ao LES ou à AR nesta população do sul do Brasil.</description><subject>Apoptosis Regulatory Proteins - genetics</subject><subject>Arthritis, Rheumatoid - genetics</subject><subject>Artrite reumatoide</subject><subject>Autoimmunity</subject><subject>Autoimunidade</subject><subject>Brazil</subject><subject>Case-Control Studies</subject><subject>Gene Frequency</subject><subject>Gene PDCD1</subject><subject>Genetic Predisposition to Disease</subject><subject>Humans</subject><subject>Lupus Erythematosus, Systemic - genetics</subject><subject>Lúpus eritematoso sistêmico</subject><subject>PD1.3 polymorphism</subject><subject>PDCD1 gene</subject><subject>Polimorfismo PD1.3</subject><subject>Polymorphism, Restriction Fragment Length</subject><subject>Programmed Cell Death 1 Receptor</subject><subject>Rheumatoid arthritis</subject><subject>Systemic lupus erythematosus</subject><issn>2255-5021</issn><issn>1809-4570</issn><issn>2255-5021</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>DOA</sourceid><recordid>eNp9kU1vFDEMhkcIRKvSP8AB5chlt_mcD4lLtQVaqRIceo8Sj4f1amYzJBmk-fdk2VJx4hQ7fv04zltV7wXfCi7qm8M2-ohbyYXZ8mbLefuqupTSmI3hUrz-J76orlM6cM5Fo6VU_G11IZtOaNPpy4puUwpALlM4sjCw73e7O8HmMK5TiPOe0sRyYGlNGScCNi7zkhjGNe9xcjmkkrljz-Iel1NOPXMx7yNlSqwUAedMnkbK67vqzeDGhNfP51X19OXz0-5-8_jt68Pu9nEDWpm8GVzvwEkECVyZvlOiFhqMwJZDLZ3rAJT3qtdK14MyjdAS2la5DpveD0pdVQ9nbB_cwc6RJhdXGxzZPxch_rDlhQQj2kFCN7TOG4NCK8Vbb3TtvZZCokbAwvp4Zs0x_FwwZTtRWWkc3RHDkqxodc1lIw0vUnmWQgwpRRxeRgtuT4bZgz0ZZk-GWd7YYlhp-vDMX_yE_UvLX3uK4NNZgOXDfhFGm4DwCNhTRMhlJfof_zdaL6kl</recordid><startdate>20161101</startdate><enddate>20161101</enddate><creator>do Canto, Luisa Matos</creator><creator>Farias, Ticiana Della Justina</creator><creator>Medeiros, Mayara Delagnelo</creator><creator>Coêlho, Cíntia Callegari</creator><creator>Sereia, Aline Fernanda Rodrigues</creator><creator>de Carlos Back, Lia Kubelka Fernandes</creator><creator>de Mello, Filipe Martins</creator><creator>Zimmermann, Adriana Fontes</creator><creator>Pereira, Ivânio Alves</creator><creator>de Souza, Ilíada Rainha</creator><general>Elsevier Editora Ltda</general><general>Sociedade Brasileira de Reumatologia</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>DOA</scope></search><sort><creationdate>20161101</creationdate><title>Association of PDCD1 polymorphism to systemic lupus erythematosus and rheumatoid arthritis susceptibility</title><author>do Canto, Luisa Matos ; Farias, Ticiana Della Justina ; Medeiros, Mayara Delagnelo ; Coêlho, Cíntia Callegari ; Sereia, Aline Fernanda Rodrigues ; de Carlos Back, Lia Kubelka Fernandes ; de Mello, Filipe Martins ; Zimmermann, Adriana Fontes ; Pereira, Ivânio Alves ; de Souza, Ilíada Rainha</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c435t-fadaca2ec2c035d931614c51e80c62aa9cc3bb3d4346f357142c883a9e7dbf33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Apoptosis Regulatory Proteins - genetics</topic><topic>Arthritis, Rheumatoid - genetics</topic><topic>Artrite reumatoide</topic><topic>Autoimmunity</topic><topic>Autoimunidade</topic><topic>Brazil</topic><topic>Case-Control Studies</topic><topic>Gene Frequency</topic><topic>Gene PDCD1</topic><topic>Genetic Predisposition to Disease</topic><topic>Humans</topic><topic>Lupus Erythematosus, Systemic - genetics</topic><topic>Lúpus eritematoso sistêmico</topic><topic>PD1.3 polymorphism</topic><topic>PDCD1 gene</topic><topic>Polimorfismo PD1.3</topic><topic>Polymorphism, Restriction Fragment Length</topic><topic>Programmed Cell Death 1 Receptor</topic><topic>Rheumatoid arthritis</topic><topic>Systemic lupus erythematosus</topic><toplevel>online_resources</toplevel><creatorcontrib>do Canto, Luisa Matos</creatorcontrib><creatorcontrib>Farias, Ticiana Della Justina</creatorcontrib><creatorcontrib>Medeiros, Mayara Delagnelo</creatorcontrib><creatorcontrib>Coêlho, Cíntia Callegari</creatorcontrib><creatorcontrib>Sereia, Aline Fernanda Rodrigues</creatorcontrib><creatorcontrib>de Carlos Back, Lia Kubelka Fernandes</creatorcontrib><creatorcontrib>de Mello, Filipe Martins</creatorcontrib><creatorcontrib>Zimmermann, Adriana Fontes</creatorcontrib><creatorcontrib>Pereira, Ivânio Alves</creatorcontrib><creatorcontrib>de Souza, Ilíada Rainha</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Revista Brasileira de Reumatologia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>do Canto, Luisa Matos</au><au>Farias, Ticiana Della Justina</au><au>Medeiros, Mayara Delagnelo</au><au>Coêlho, Cíntia Callegari</au><au>Sereia, Aline Fernanda Rodrigues</au><au>de Carlos Back, Lia Kubelka Fernandes</au><au>de Mello, Filipe Martins</au><au>Zimmermann, Adriana Fontes</au><au>Pereira, Ivânio Alves</au><au>de Souza, Ilíada Rainha</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of PDCD1 polymorphism to systemic lupus erythematosus and rheumatoid arthritis susceptibility</atitle><jtitle>Revista Brasileira de Reumatologia</jtitle><addtitle>Rev Bras Reumatol Engl Ed</addtitle><date>2016-11-01</date><risdate>2016</risdate><volume>56</volume><issue>6</issue><spage>483</spage><epage>489</epage><pages>483-489</pages><issn>2255-5021</issn><issn>1809-4570</issn><eissn>2255-5021</eissn><abstract>This study aims to analyze the relationship of programmed cell death 1 (PDCD1) gene polymorphism (PD1.3G/A – rs11568821) with features of systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) in a Southern Brazilian population.
Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was performed in 95 SLE and 87 RA patients and 128 control group individuals from Santa Catarina, Southern Brazil. The Hardy–Weinberg equilibrium (HWE) test, and odds ratio (OR) were analyzed, considering CI 95% and p≤0.05.
The PD1.3A allele frequencies were 0.095 (SLE), 0.115 (RA) and 0.078 (controls). The genotypes of the control group were in HWE, while those of SLE and RA patients were not. However, we found no association between PD1.3 polymorphism and the SLE or RA susceptibility, nor clinical or epidemiological data.
There was no significant association between PD1.3 polymorphism and SLE or RA susceptibility in this Southern Brazilian population.
Este estudo teve como objetivo analisar a relação entre o polimorfismo do gene PDCD1 (Programmed cell death 1) (PD1.3G/A – rs11568821) com caraterísticas do lúpus eritematoso sistêmico (LES) e da artrite reumatoide (AR) em uma população do sul do Brasil.
A técnica de PCR-RFLP (Polymerase Chain Reaction-Restriction Fragment Lenght Polymorphism) foi utilizada para analisar amostras de 95 pacientes com LES e 87 com AR e 128 indivíduos do grupo controle de Santa Catarina, sul do Brasil. Foi analisada a probabilidade de equilíbrio de Hardy–Weinberg (EHW) e o odds ratio (OR), considerando um IC 95% e p≤0.05.
As frequências alélicas PD1.3A foram de 0,095 (LES), 0,115 (AR) e 0,078 (controles). Os genótipos do grupo controle estavam em EHW, enquanto aqueles dos pacientes com LES e AR não estavam. No entanto, não foi encontrada nenhuma associação entre o polimorfismo PD1.3 e a susceptibilidade ao LES ou à AR, nem com dados clínicos ou epidemiológicos.
Não foi encontrada associação significativa entre o polimorfismo PD1.3 e a susceptibilidade ao LES ou à AR nesta população do sul do Brasil.</abstract><cop>Brazil</cop><pub>Elsevier Editora Ltda</pub><pmid>27914594</pmid><doi>10.1016/j.rbre.2015.07.008</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Revista Brasileira de Reumatologia, 2016-11, Vol.56 (6), p.483-489 |
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| subjects | Apoptosis Regulatory Proteins - genetics Arthritis, Rheumatoid - genetics Artrite reumatoide Autoimmunity Autoimunidade Brazil Case-Control Studies Gene Frequency Gene PDCD1 Genetic Predisposition to Disease Humans Lupus Erythematosus, Systemic - genetics Lúpus eritematoso sistêmico PD1.3 polymorphism PDCD1 gene Polimorfismo PD1.3 Polymorphism, Restriction Fragment Length Programmed Cell Death 1 Receptor Rheumatoid arthritis Systemic lupus erythematosus |
| title | Association of PDCD1 polymorphism to systemic lupus erythematosus and rheumatoid arthritis susceptibility |
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