Both secreted and the cellular levels of BDNF attenuated due to tau hyperphosphorylation in primary cultures of cortical neurons

•OKA-induced tau hyperphosphorylation resulted in disruption of neurites.•This process lead to reduction in the levels of BDNF release in cortical neurons.•BDNF reduction might depend on the structural alterations in the neurites.•Altered neurotrophin levels in tauopathies might be associated with n...

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