Normal human gingival fibroblasts undergo cytostasis and apoptosis after long-term exposure to butyric acid

The causes of periodontal disease are complex. Butyric acid, a metabolite of periodontopathic bacteria such as Porphyromonas gingivalis, acts as a histone deacetylase inhibitor that has a direct effect on mRNA expression. Butyric acid produced by Clostridium butyricum in the intestinal tract induces...

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Veröffentlicht in:	Biochemical and biophysical research communications 2017-01, Vol.482 (4), p.1122-1128
Hauptverfasser:	Shirasugi, Michihiro, Nishioka, Keisuke, Yamamoto, Toshiro, Nakaya, Takaaki, Kanamura, Narisato
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Butyric acid Butyric Acid - chemistry Caspase 8 - metabolism Cell Division Cell Survival Cytokines - metabolism DNA Damage Fibroblasts - drug effects Fibroblasts - metabolism Gingiva - drug effects Gingiva - metabolism Human gingival fibroblast Humans Inflammation Mice Periodontal disease RAW 264.7 Cells TNF-alpha Tumor Necrosis Factor-alpha - metabolism Tumor Suppressor Protein p53 - metabolism
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