Glycolysis without pyruvate kinase in Clostridium thermocellum

The metabolism of Clostridium thermocellum is notable in that it assimilates sugar via the EMP pathway but does not possess a pyruvate kinase enzyme. In the wild type organism, there are three proposed pathways for conversion of phosphoenolpyruvate (PEP) to pyruvate, which differ in their cofactor u...

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Veröffentlicht in:	Metabolic engineering 2017-01, Vol.39, p.169-180
Hauptverfasser:	Olson, Daniel G., Hörl, Manuel, Fuhrer, Tobias, Cui, Jingxuan, Zhou, Jilai, Maloney, Marybeth I., Amador-Noguez, Daniel, Tian, Liang, Sauer, Uwe, Lynd, Lee R.
Format:	Artikel
Sprache:	eng
Schlagworte:	13C flux analysis Biosynthetic Pathways - physiology Carbon-13 Magnetic Resonance Spectroscopy - methods Clostridium thermocellum - physiology Glucose - metabolism Glycolysis - physiology Malate dehydrogenase Malate shunt Malates - metabolism Malic enzyme Metabolic Flux Analysis - methods Metabolic Networks and Pathways - physiology Models, Biological Oxaloacetate decarboxylase Phosphoenolpyruvate - metabolism Pyruvate kinase Pyruvate Kinase - metabolism Pyruvic Acid - isolation & purification Pyruvic Acid - metabolism
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