Perinatal hypothalamic-pituitary-adrenal axis regulation among women with eating disorders and their infants

Highlights • Eating disorders can affect pregnancy outcomes and impact on child development. • Foetal programming is a potential mechanism for these outcomes. • During pregnancy women with eating disorders show blunted diurnal cortisol rhythms. • In the postnatal period their infants also have a hei...

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Veröffentlicht in:	Psychoneuroendocrinology 2017-02, Vol.76, p.127-134
Hauptverfasser:	Easter, A, Taborelli, E, Bye, A, Zunszain, P.A, Pariante, C.M, Treasure, J, Schmidt, U, Micali, N
Format:	Artikel
Sprache:	eng
Schlagworte:	Cortisol Eating disorders Endocrinology & Metabolism Feeding and Eating Disorders - metabolism Feeding and Eating Disorders - physiopathology Female Humans Hydrocortisone - metabolism Hypothalamic-pituitary-adrenal axis Hypothalamo-Hypophyseal System - metabolism Hypothalamo-Hypophyseal System - physiopathology Infant Longitudinal Studies Male Perinatal Pituitary-Adrenal System - metabolism Pituitary-Adrenal System - physiopathology Pregnancy Pregnancy Complications - metabolism Pregnancy Complications - physiopathology Psychiatry Stress Stress, Psychological - metabolism Stress, Psychological - physiopathology
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Zusammenfassung:	Highlights • Eating disorders can affect pregnancy outcomes and impact on child development. • Foetal programming is a potential mechanism for these outcomes. • During pregnancy women with eating disorders show blunted diurnal cortisol rhythms. • In the postnatal period their infants also have a heightened response to stress. • Indicating intergenerational effects of hypothalamic-pituitary-adrenal axis dysfunction.
ISSN:	0306-4530 1873-3360
DOI:	10.1016/j.psyneuen.2016.11.004