Prevalence and factors associated with cryptococcal antigenemia in HIV-infected patients in Cotonou/Benin
Determine the prevalence of cryptococcal antigenemia and associated factors in HIV-infected patients in Cotonou in order to introduce systematic screening in national guidelines. This is a cross-sectional, descriptive and analytical study conducted from June to September 2015 in four outpatient trea...
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| Veröffentlicht in: | Journal de mycologie médicale 2016-12, Vol.26 (4), p.391-397 |
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| container_title | Journal de mycologie médicale |
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| creator | Ogouyèmi-Hounto, A Zannou, D M Ayihounton, G Ahouada, C Azon-Kouanou, A Acakpo, J Sissinto Savi de Tove, Y Kinde Gazard, D |
| description | Determine the prevalence of cryptococcal antigenemia and associated factors in HIV-infected patients in Cotonou in order to introduce systematic screening in national guidelines.
This is a cross-sectional, descriptive and analytical study conducted from June to September 2015 in four outpatient treatment centers with adult patients infected with HIV, receiving or not antiretroviral treatment with a number of CD4≤200cell/μL and who have given their informed consent to participate in the study. For each enrolled patient, after signing the informed consent form, it was made a clinical examination and administration of a questionnaire to collect general information, treatment and biological data. Then a blood sample for counting CD4 lymphocytes and the search of cryptococcal antigenemia were done.
In total, 355 patients were included in the study with a mean age of 40±10.2years. The overall prevalence of cryptococcal antigenemia is 1.7%. All patient with cryptococcal antigenemia have a CD4 count below 100cells/μL with a majority having CD4 count below 50cells/μL. Body mass index |
| doi_str_mv | 10.1016/j.mycmed.2016.08.007 |
| format | Article |
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This is a cross-sectional, descriptive and analytical study conducted from June to September 2015 in four outpatient treatment centers with adult patients infected with HIV, receiving or not antiretroviral treatment with a number of CD4≤200cell/μL and who have given their informed consent to participate in the study. For each enrolled patient, after signing the informed consent form, it was made a clinical examination and administration of a questionnaire to collect general information, treatment and biological data. Then a blood sample for counting CD4 lymphocytes and the search of cryptococcal antigenemia were done.
In total, 355 patients were included in the study with a mean age of 40±10.2years. The overall prevalence of cryptococcal antigenemia is 1.7%. All patient with cryptococcal antigenemia have a CD4 count below 100cells/μL with a majority having CD4 count below 50cells/μL. Body mass index<18.5kg/m
, an alteration of the general condition with a CD4 lymphocyte counts<50cells/μL are the main factors associated with the occurrence of cryptococcal antigenemia.
This pilot study showed a low prevalence of cryptococcal antigenemia in the study population, but higher in highly immuno-deficient patients with CD4 counts<50cells/μl. Given the results obtained, the introduction of routine screening among patients infected with HIV could be reserved to those with CD4 counts<50cells/μl.</description><identifier>EISSN: 1773-0449</identifier><identifier>DOI: 10.1016/j.mycmed.2016.08.007</identifier><identifier>PMID: 27641486</identifier><language>fre</language><publisher>France</publisher><subject>Adult ; AIDS-Related Opportunistic Infections - blood ; AIDS-Related Opportunistic Infections - epidemiology ; Antigens, Fungal - blood ; Benin - epidemiology ; CD4 Lymphocyte Count ; Cross-Sectional Studies ; Cryptococcosis - blood ; Cryptococcosis - complications ; Cryptococcosis - epidemiology ; Cryptococcus - immunology ; Female ; HIV Infections - blood ; HIV Infections - complications ; HIV Infections - epidemiology ; HIV-1 ; Humans ; Male ; Meningitis, Cryptococcal - blood ; Meningitis, Cryptococcal - complications ; Meningitis, Cryptococcal - epidemiology ; Middle Aged ; Pilot Projects ; Prevalence ; Risk Factors</subject><ispartof>Journal de mycologie médicale, 2016-12, Vol.26 (4), p.391-397</ispartof><rights>Copyright © 2016 Elsevier Masson SAS. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27641486$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ogouyèmi-Hounto, A</creatorcontrib><creatorcontrib>Zannou, D M</creatorcontrib><creatorcontrib>Ayihounton, G</creatorcontrib><creatorcontrib>Ahouada, C</creatorcontrib><creatorcontrib>Azon-Kouanou, A</creatorcontrib><creatorcontrib>Acakpo, J</creatorcontrib><creatorcontrib>Sissinto Savi de Tove, Y</creatorcontrib><creatorcontrib>Kinde Gazard, D</creatorcontrib><title>Prevalence and factors associated with cryptococcal antigenemia in HIV-infected patients in Cotonou/Benin</title><title>Journal de mycologie médicale</title><addtitle>J Mycol Med</addtitle><description>Determine the prevalence of cryptococcal antigenemia and associated factors in HIV-infected patients in Cotonou in order to introduce systematic screening in national guidelines.
This is a cross-sectional, descriptive and analytical study conducted from June to September 2015 in four outpatient treatment centers with adult patients infected with HIV, receiving or not antiretroviral treatment with a number of CD4≤200cell/μL and who have given their informed consent to participate in the study. For each enrolled patient, after signing the informed consent form, it was made a clinical examination and administration of a questionnaire to collect general information, treatment and biological data. Then a blood sample for counting CD4 lymphocytes and the search of cryptococcal antigenemia were done.
In total, 355 patients were included in the study with a mean age of 40±10.2years. The overall prevalence of cryptococcal antigenemia is 1.7%. All patient with cryptococcal antigenemia have a CD4 count below 100cells/μL with a majority having CD4 count below 50cells/μL. Body mass index<18.5kg/m
, an alteration of the general condition with a CD4 lymphocyte counts<50cells/μL are the main factors associated with the occurrence of cryptococcal antigenemia.
This pilot study showed a low prevalence of cryptococcal antigenemia in the study population, but higher in highly immuno-deficient patients with CD4 counts<50cells/μl. Given the results obtained, the introduction of routine screening among patients infected with HIV could be reserved to those with CD4 counts<50cells/μl.</description><subject>Adult</subject><subject>AIDS-Related Opportunistic Infections - blood</subject><subject>AIDS-Related Opportunistic Infections - epidemiology</subject><subject>Antigens, Fungal - blood</subject><subject>Benin - epidemiology</subject><subject>CD4 Lymphocyte Count</subject><subject>Cross-Sectional Studies</subject><subject>Cryptococcosis - blood</subject><subject>Cryptococcosis - complications</subject><subject>Cryptococcosis - epidemiology</subject><subject>Cryptococcus - immunology</subject><subject>Female</subject><subject>HIV Infections - blood</subject><subject>HIV Infections - complications</subject><subject>HIV Infections - epidemiology</subject><subject>HIV-1</subject><subject>Humans</subject><subject>Male</subject><subject>Meningitis, Cryptococcal - blood</subject><subject>Meningitis, Cryptococcal - complications</subject><subject>Meningitis, Cryptococcal - epidemiology</subject><subject>Middle Aged</subject><subject>Pilot Projects</subject><subject>Prevalence</subject><subject>Risk Factors</subject><issn>1773-0449</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kE9LwzAchoMgbk6_gUiPXtolTZo_Rx3ODQZ6UK_l1zTVjDapTars29vhPL28vA_v4UHohuCMYMKX-6w76M7UWT61DMsMY3GG5kQImmLG1AxdhrDHuOBFwS7QLBecESb5HNmXwXxDa5w2Cbg6aUBHP4QEQvDaQjR18mPjZ6KHQx-99lpDO4HRfhhnOguJdclm-55a1xh9pHuI1rgYjsPKR-_8uHwwzrordN5AG8z1KRfobf34utqku-en7ep-l_aEkZjKCkiFaU4FiDoXtKCCKF3zSjaY57RQGisGkgggtRJF1ehGY9JgqSQvqAK6QHd_v_3gv0YTYtnZoE3bgjN-DCWRjOOcE6Ym9PaEjtVkr-wH28FwKP_10F9ouWfG</recordid><startdate>201612</startdate><enddate>201612</enddate><creator>Ogouyèmi-Hounto, A</creator><creator>Zannou, D M</creator><creator>Ayihounton, G</creator><creator>Ahouada, C</creator><creator>Azon-Kouanou, A</creator><creator>Acakpo, J</creator><creator>Sissinto Savi de Tove, Y</creator><creator>Kinde Gazard, D</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201612</creationdate><title>Prevalence and factors associated with cryptococcal antigenemia in HIV-infected patients in Cotonou/Benin</title><author>Ogouyèmi-Hounto, A ; Zannou, D M ; Ayihounton, G ; Ahouada, C ; Azon-Kouanou, A ; Acakpo, J ; Sissinto Savi de Tove, Y ; Kinde Gazard, D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p141t-8ba1b03237a7d27353719cd6b8f062359c094a817a1d975bfcfc01f08986539a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>fre</language><creationdate>2016</creationdate><topic>Adult</topic><topic>AIDS-Related Opportunistic Infections - blood</topic><topic>AIDS-Related Opportunistic Infections - epidemiology</topic><topic>Antigens, Fungal - blood</topic><topic>Benin - epidemiology</topic><topic>CD4 Lymphocyte Count</topic><topic>Cross-Sectional Studies</topic><topic>Cryptococcosis - blood</topic><topic>Cryptococcosis - complications</topic><topic>Cryptococcosis - epidemiology</topic><topic>Cryptococcus - immunology</topic><topic>Female</topic><topic>HIV Infections - blood</topic><topic>HIV Infections - complications</topic><topic>HIV Infections - epidemiology</topic><topic>HIV-1</topic><topic>Humans</topic><topic>Male</topic><topic>Meningitis, Cryptococcal - blood</topic><topic>Meningitis, Cryptococcal - complications</topic><topic>Meningitis, Cryptococcal - epidemiology</topic><topic>Middle Aged</topic><topic>Pilot Projects</topic><topic>Prevalence</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ogouyèmi-Hounto, A</creatorcontrib><creatorcontrib>Zannou, D M</creatorcontrib><creatorcontrib>Ayihounton, G</creatorcontrib><creatorcontrib>Ahouada, C</creatorcontrib><creatorcontrib>Azon-Kouanou, A</creatorcontrib><creatorcontrib>Acakpo, J</creatorcontrib><creatorcontrib>Sissinto Savi de Tove, Y</creatorcontrib><creatorcontrib>Kinde Gazard, D</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Journal de mycologie médicale</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ogouyèmi-Hounto, A</au><au>Zannou, D M</au><au>Ayihounton, G</au><au>Ahouada, C</au><au>Azon-Kouanou, A</au><au>Acakpo, J</au><au>Sissinto Savi de Tove, Y</au><au>Kinde Gazard, D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevalence and factors associated with cryptococcal antigenemia in HIV-infected patients in Cotonou/Benin</atitle><jtitle>Journal de mycologie médicale</jtitle><addtitle>J Mycol Med</addtitle><date>2016-12</date><risdate>2016</risdate><volume>26</volume><issue>4</issue><spage>391</spage><epage>397</epage><pages>391-397</pages><eissn>1773-0449</eissn><abstract>Determine the prevalence of cryptococcal antigenemia and associated factors in HIV-infected patients in Cotonou in order to introduce systematic screening in national guidelines.
This is a cross-sectional, descriptive and analytical study conducted from June to September 2015 in four outpatient treatment centers with adult patients infected with HIV, receiving or not antiretroviral treatment with a number of CD4≤200cell/μL and who have given their informed consent to participate in the study. For each enrolled patient, after signing the informed consent form, it was made a clinical examination and administration of a questionnaire to collect general information, treatment and biological data. Then a blood sample for counting CD4 lymphocytes and the search of cryptococcal antigenemia were done.
In total, 355 patients were included in the study with a mean age of 40±10.2years. The overall prevalence of cryptococcal antigenemia is 1.7%. All patient with cryptococcal antigenemia have a CD4 count below 100cells/μL with a majority having CD4 count below 50cells/μL. Body mass index<18.5kg/m
, an alteration of the general condition with a CD4 lymphocyte counts<50cells/μL are the main factors associated with the occurrence of cryptococcal antigenemia.
This pilot study showed a low prevalence of cryptococcal antigenemia in the study population, but higher in highly immuno-deficient patients with CD4 counts<50cells/μl. Given the results obtained, the introduction of routine screening among patients infected with HIV could be reserved to those with CD4 counts<50cells/μl.</abstract><cop>France</cop><pmid>27641486</pmid><doi>10.1016/j.mycmed.2016.08.007</doi><tpages>7</tpages></addata></record> |
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| subjects | Adult AIDS-Related Opportunistic Infections - blood AIDS-Related Opportunistic Infections - epidemiology Antigens, Fungal - blood Benin - epidemiology CD4 Lymphocyte Count Cross-Sectional Studies Cryptococcosis - blood Cryptococcosis - complications Cryptococcosis - epidemiology Cryptococcus - immunology Female HIV Infections - blood HIV Infections - complications HIV Infections - epidemiology HIV-1 Humans Male Meningitis, Cryptococcal - blood Meningitis, Cryptococcal - complications Meningitis, Cryptococcal - epidemiology Middle Aged Pilot Projects Prevalence Risk Factors |
| title | Prevalence and factors associated with cryptococcal antigenemia in HIV-infected patients in Cotonou/Benin |
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