Acetylation of PCNA Sliding Surface by Eco1 Promotes Genome Stability through Homologous Recombination

During DNA replication, proliferating cell nuclear antigen (PCNA) adopts a ring-shaped structure to promote processive DNA synthesis, acting as a sliding clamp for polymerases. Known posttranslational modifications function at the outer surface of the PCNA ring to favor DNA damage bypass. Here, we d...

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Veröffentlicht in:	Molecular cell 2017-01, Vol.65 (1), p.78-90
Hauptverfasser:	Billon, Pierre, Li, Jian, Lambert, Jean-Philippe, Chen, Yizhang, Tremblay, Véronique, Brunzelle, Joseph S., Gingras, Anne-Claude, Verreault, Alain, Sugiyama, Tomohiko, Couture, Jean-Francois, Côté, Jacques
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Acetyltransferases - chemistry Acetyltransferases - genetics Acetyltransferases - metabolism Chromatids Chromosomes, Fungal DNA Damage DNA Polymerase III - genetics DNA Polymerase III - metabolism DNA polymerases Eco1 Genomic Instability Genotype homologous recombination Humans Lysine lysine acetylation Models, Molecular Mutation Nuclear Proteins - chemistry Nuclear Proteins - genetics Nuclear Proteins - metabolism PCNA Phenotype Proliferating Cell Nuclear Antigen - chemistry Proliferating Cell Nuclear Antigen - genetics Proliferating Cell Nuclear Antigen - metabolism Protein Conformation Protein Processing, Post-Translational Recombinational DNA Repair Saccharomyces cerevisiae - enzymology Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae Proteins - chemistry Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism Structure-Activity Relationship translesion synthesis
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