Alterations in metabolism and gene expression in brain regions during cuprizone‐induced demyelination and remyelination

Exposure of mice to the copper chelator, cuprizone, results in CNS demyelination. There is remyelination after removal of the metabolic insult. We present brain regional studies identifying corpus callosum as particularly severely affected; 65% of cerebroside is lost after 6 weeks of exposure. We ex...

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Veröffentlicht in:	Journal of neurochemistry 2002-07, Vol.82 (1), p.126-136
Hauptverfasser:	Jurevics, Helga, Largent, Carrie, Hostettler, Janell, Sammond, Deanne W., K. Matsushima, Glenn, Toews, Arrel D., Morell, Pierre
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biochemistry and metabolism Biological and medical sciences Biomarkers - analysis Brain - drug effects Brain - metabolism Brain Stem - chemistry Brain Stem - metabolism Central nervous system ceramide galactosyltransferase Cerebellum - chemistry Cerebellum - metabolism cerebroside Cerebrosides - analysis Cerebrosides - metabolism Chelating Agents cholesterol Cholesterol - analysis Cholesterol - metabolism Corpus Callosum - chemistry Corpus Callosum - drug effects Corpus Callosum - metabolism Cuprizone Demyelinating Diseases - chemically induced Demyelinating Diseases - genetics Demyelinating Diseases - metabolism Disease Models, Animal Disease Progression Fundamental and applied biological sciences. Psychology Galactosyltransferases - genetics Galactosyltransferases - metabolism Gene Expression Profiling Gene Expression Regulation - drug effects GeneChip Mice Mice, Inbred C3H myelin myelin basic protein Myelin Basic Protein - analysis Myelin Basic Protein - metabolism Myelin Sheath - metabolism N-Acylsphingosine Galactosyltransferase Oligonucleotide Array Sequence Analysis RNA, Messenger - analysis RNA, Messenger - metabolism Vertebrates: nervous system and sense organs
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