Changes in Respiratory Function during Treatment with Combination of Analgesic Substances Trimeperidine and Dexmedetomidine
The effects of analgesic substances trimeperidine and dexmedetomidine and their combinations in different proportions (0.75:0.25, 0.5:0.5, 0.25:0.75 of the medium effective doses of each substance) on respiratory function was studied in experiments on rats. Administration of substances in 1 ED 50 by...
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| Veröffentlicht in: | Bulletin of experimental biology and medicine 2016-12, Vol.162 (2), p.215-219 |
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| creator | Yudin, M. A. Vengerovich, N. G. Sagalov, G. S. Vahvijanen, M. S. Bykov, V. N. Chepur, S. V. |
| description | The effects of analgesic substances trimeperidine and dexmedetomidine and their combinations in different proportions (0.75:0.25, 0.5:0.5, 0.25:0.75 of the medium effective doses of each substance) on respiratory function was studied in experiments on rats. Administration of substances in 1 ED
50
by analgesic effect (corresponded to medium therapeutic dose of trimeperidine in humans) was characterized by significantly longer suppression of respiration over 90 min in comparison with combined treatment with these substances. Administration of the substances in a dose of 8 ED
50
by analgesic effect (corresponded to daily therapeutic dose) over 60 min was followed by more than 3-fold reduction in respiration frequency and respiratory minute volume, more pronounced in animals receiving trimeperidine. Combined administration of these drugs in the specifi ed dose induced less pronounced suppression of respiration and combined administration of trimeperidine and dexmedetomidine in proportion of 0.75:0.25 signifi cantly reduced the period of restoration of respiratory parameters in comparison with animals receiving single substances. |
| doi_str_mv | 10.1007/s10517-016-3579-8 |
| format | Article |
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50
by analgesic effect (corresponded to medium therapeutic dose of trimeperidine in humans) was characterized by significantly longer suppression of respiration over 90 min in comparison with combined treatment with these substances. Administration of the substances in a dose of 8 ED
50
by analgesic effect (corresponded to daily therapeutic dose) over 60 min was followed by more than 3-fold reduction in respiration frequency and respiratory minute volume, more pronounced in animals receiving trimeperidine. Combined administration of these drugs in the specifi ed dose induced less pronounced suppression of respiration and combined administration of trimeperidine and dexmedetomidine in proportion of 0.75:0.25 signifi cantly reduced the period of restoration of respiratory parameters in comparison with animals receiving single substances.</description><identifier>ISSN: 0007-4888</identifier><identifier>EISSN: 1573-8221</identifier><identifier>DOI: 10.1007/s10517-016-3579-8</identifier><identifier>PMID: 27913936</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Analgesics ; Analgesics, Non-Narcotic - pharmacology ; Analgesics, Opioid - pharmacology ; Analysis ; Animal experimentation ; Animals ; Animals, Outbred Strains ; Biomedical and Life Sciences ; Biomedicine ; Cell Biology ; Dexmedetomidine - pharmacology ; Drug Administration Schedule ; Drug Combinations ; Drug Dosage Calculations ; Health aspects ; Internal Medicine ; Laboratory Medicine ; Male ; Pathology ; Promedol - pharmacology ; Rats ; Respiration ; Respiration - drug effects ; Respiratory function ; Respiratory Function Tests</subject><ispartof>Bulletin of experimental biology and medicine, 2016-12, Vol.162 (2), p.215-219</ispartof><rights>Springer Science+Business Media New York 2016</rights><rights>COPYRIGHT 2016 Springer</rights><rights>Bulletin of Experimental Biology and Medicine is a copyright of Springer, 2016.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c540t-fd15630da63b70cb42fc7476e9e452564de04523dabd36900b9290a04d12fa733</citedby><cites>FETCH-LOGICAL-c540t-fd15630da63b70cb42fc7476e9e452564de04523dabd36900b9290a04d12fa733</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10517-016-3579-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10517-016-3579-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27913936$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yudin, M. A.</creatorcontrib><creatorcontrib>Vengerovich, N. G.</creatorcontrib><creatorcontrib>Sagalov, G. S.</creatorcontrib><creatorcontrib>Vahvijanen, M. S.</creatorcontrib><creatorcontrib>Bykov, V. N.</creatorcontrib><creatorcontrib>Chepur, S. V.</creatorcontrib><title>Changes in Respiratory Function during Treatment with Combination of Analgesic Substances Trimeperidine and Dexmedetomidine</title><title>Bulletin of experimental biology and medicine</title><addtitle>Bull Exp Biol Med</addtitle><addtitle>Bull Exp Biol Med</addtitle><description>The effects of analgesic substances trimeperidine and dexmedetomidine and their combinations in different proportions (0.75:0.25, 0.5:0.5, 0.25:0.75 of the medium effective doses of each substance) on respiratory function was studied in experiments on rats. Administration of substances in 1 ED
50
by analgesic effect (corresponded to medium therapeutic dose of trimeperidine in humans) was characterized by significantly longer suppression of respiration over 90 min in comparison with combined treatment with these substances. Administration of the substances in a dose of 8 ED
50
by analgesic effect (corresponded to daily therapeutic dose) over 60 min was followed by more than 3-fold reduction in respiration frequency and respiratory minute volume, more pronounced in animals receiving trimeperidine. Combined administration of these drugs in the specifi ed dose induced less pronounced suppression of respiration and combined administration of trimeperidine and dexmedetomidine in proportion of 0.75:0.25 signifi cantly reduced the period of restoration of respiratory parameters in comparison with animals receiving single substances.</description><subject>Analgesics</subject><subject>Analgesics, Non-Narcotic - pharmacology</subject><subject>Analgesics, Opioid - pharmacology</subject><subject>Analysis</subject><subject>Animal experimentation</subject><subject>Animals</subject><subject>Animals, Outbred Strains</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cell Biology</subject><subject>Dexmedetomidine - pharmacology</subject><subject>Drug Administration Schedule</subject><subject>Drug Combinations</subject><subject>Drug Dosage Calculations</subject><subject>Health aspects</subject><subject>Internal Medicine</subject><subject>Laboratory Medicine</subject><subject>Male</subject><subject>Pathology</subject><subject>Promedol - pharmacology</subject><subject>Rats</subject><subject>Respiration</subject><subject>Respiration - drug effects</subject><subject>Respiratory function</subject><subject>Respiratory Function Tests</subject><issn>0007-4888</issn><issn>1573-8221</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1klFvFCEUhYnR2O3qD_DFkJiYvkyFgWFmHjerVZMmJro-Ewbu7NLMwAhMauOfl-lWbY2GB-DmO4fcy0HoBSXnlJD6TaSkonVBqChYVbdF8witaFWzoilL-hitSIYK3jTNCTqN8Wq5EkGfopOybilrmVihH9uDcnuI2Dr8GeJkg0o-3OCL2elkvcNmDtbt8S6ASiO4hK9tOuCtHzvr1C3he7xxasgmVuMvcxeTcjo77oIdYYJgjXWAlTP4LXwfwUDy423tGXrSqyHC87t9jb5evNttPxSXn95_3G4uC11xkore0EowYpRgXU10x8te17wW0AKvykpwAyQfmFGdYaIlpGvLlijCDS17VTO2RmdH3yn4bzPEJEcbNQyDcuDnKGnDq4Zxll9Zo1d_oVd-Drm7hRKkaQWpyB9qrwaQ1vU-BaUXU7nhbZPNBFmo839QeRkYrfYOepvrDwSv7wkOoIZ0iH6YlynHhyA9gjr4GAP0csqzVuFGUiKXZMhjMmROhlySIZuseXnX2dzlT_it-BWFDJRHIE7Lj0O41_p_XX8CjevCIQ</recordid><startdate>20161201</startdate><enddate>20161201</enddate><creator>Yudin, M. 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A.</au><au>Vengerovich, N. G.</au><au>Sagalov, G. S.</au><au>Vahvijanen, M. S.</au><au>Bykov, V. N.</au><au>Chepur, S. V.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Changes in Respiratory Function during Treatment with Combination of Analgesic Substances Trimeperidine and Dexmedetomidine</atitle><jtitle>Bulletin of experimental biology and medicine</jtitle><stitle>Bull Exp Biol Med</stitle><addtitle>Bull Exp Biol Med</addtitle><date>2016-12-01</date><risdate>2016</risdate><volume>162</volume><issue>2</issue><spage>215</spage><epage>219</epage><pages>215-219</pages><issn>0007-4888</issn><eissn>1573-8221</eissn><abstract>The effects of analgesic substances trimeperidine and dexmedetomidine and their combinations in different proportions (0.75:0.25, 0.5:0.5, 0.25:0.75 of the medium effective doses of each substance) on respiratory function was studied in experiments on rats. Administration of substances in 1 ED
50
by analgesic effect (corresponded to medium therapeutic dose of trimeperidine in humans) was characterized by significantly longer suppression of respiration over 90 min in comparison with combined treatment with these substances. Administration of the substances in a dose of 8 ED
50
by analgesic effect (corresponded to daily therapeutic dose) over 60 min was followed by more than 3-fold reduction in respiration frequency and respiratory minute volume, more pronounced in animals receiving trimeperidine. Combined administration of these drugs in the specifi ed dose induced less pronounced suppression of respiration and combined administration of trimeperidine and dexmedetomidine in proportion of 0.75:0.25 signifi cantly reduced the period of restoration of respiratory parameters in comparison with animals receiving single substances.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>27913936</pmid><doi>10.1007/s10517-016-3579-8</doi><tpages>5</tpages></addata></record> |
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| subjects | Analgesics Analgesics, Non-Narcotic - pharmacology Analgesics, Opioid - pharmacology Analysis Animal experimentation Animals Animals, Outbred Strains Biomedical and Life Sciences Biomedicine Cell Biology Dexmedetomidine - pharmacology Drug Administration Schedule Drug Combinations Drug Dosage Calculations Health aspects Internal Medicine Laboratory Medicine Male Pathology Promedol - pharmacology Rats Respiration Respiration - drug effects Respiratory function Respiratory Function Tests |
| title | Changes in Respiratory Function during Treatment with Combination of Analgesic Substances Trimeperidine and Dexmedetomidine |
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