Visible-light-mediated generation of nitrile oxides for the photoredox synthesis of isoxazolines and isoxazoles

Visible-light-mediated generation of nitrile oxides for the photoredox synthesis of isoxazolines and isoxazoles

Visible-light photoredox catalysis enables the synthesis of biologically relevant isoxazolines and isoxazoles from hydroxyimino acids. The process shows broad functional group compatibility and mechanistic and computational studies support a visible-light-mediated generation of nitrile oxides by two...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2016-01, Vol.52 (83), p.12302-12305
Hauptverfasser: Svejstrup, Thomas D, Zawodny, Wojciech, Douglas, James J, Bidgeli, Damon, Sheikh, Nadeem S, Leonori, Daniele
Format: Artikel
Sprache:eng
Schlagworte:
Catalysis
Compatibility
Functional groups
Nitriles
Oxides
Single electrons
Synthesis
Synthesis (chemistry)
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Beschreibung
Zusammenfassung:Visible-light photoredox catalysis enables the synthesis of biologically relevant isoxazolines and isoxazoles from hydroxyimino acids. The process shows broad functional group compatibility and mechanistic and computational studies support a visible-light-mediated generation of nitrile oxides by two sequential oxidative single electron transfer processes.
ISSN:1359-7345
1364-548X
DOI:10.1039/c6cc06029c