Do ARTs affect the incidence of monozygotic twinning?
STUDY QUESTION Does the manipulation of gametes or embryos during ARTs increase the risk for monozygotic twinning (MZT)? SUMMARY ANSWER Frozen embryo transfer (ET) is associated with a lower MZT rate, while blastocyst culture is associated with an increased risk of monozygotic pregnancy. WHAT IS KNO...
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| Veröffentlicht in: | Human reproduction (Oxford) 2016-11, Vol.31 (11), p.2435-2441 |
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| creator | Mateizel, I. Santos-Ribeiro, S. Done, E. Van Landuyt, L. Van de Velde, H. Tournaye, H. Verheyen, G. |
| description | STUDY QUESTION
Does the manipulation of gametes or embryos during ARTs increase the risk for monozygotic twinning (MZT)?
SUMMARY ANSWER
Frozen embryo transfer (ET) is associated with a lower MZT rate, while blastocyst culture is associated with an increased risk of monozygotic pregnancy.
WHAT IS KNOWN ALREADY
Monozygotic twins have a higher risk for perinatal complications. Although an increased incidence of monozygotic pregnancies after ART has been previously reported, data regarding the possible impact of different laboratory procedures are conflicting.
STUDY DESIGN, SIZE, DURATION
All clinical pregnancies after single ET carried out in our centre between 2004 and 2013 (n = 6096) were retrospectively analysed for the incidence of MZT. The effect of different laboratory procedures on the incidence of MZT was evaluated.
PARTICIPANTS/MATERIALS, SETTING, METHODS
The following ART risk factors were assessed: maternal age, type of ET (fresh versus frozen), zona pellucida (ZP) manipulation (specifically, ICSI, embryo biopsy and assisted hatching), use of donor oocytes, embryo stage at time of ET (cleavage, compaction, early or advanced blastocyst) and culture media.
MAIN RESULTS AND THE ROLE OF CHANCE
The overall MZT rate was 2.2% (136/6096). Frozen ET was associated with a significant reduction in MZT incidence (adjusted odds ratio (aOR) 0.48, 95% CI 0.29–0.80), while blastocyst transfer (early or advanced blastocyst) was associated with a significant increase in MZT risk (aOR 2.70, 95% CI 1.36–5.34; aOR 2.05, 95% CI 1.29–3.26, respectively). No significant differences were found between the MZT and singleton (non-MZT) groups regarding maternal age, the use of different ZP manipulation techniques, not type of culture media used.
LIMITATION, REASONS FOR CAUTION
This study is limited by its retrospective nature and the fact that monozygosity was not confirmed by genetic testing. Furthermore, since monozygotic pregnancy is a rare event, other ART parameters that may influence its incidence could not be assessed during our analysis.
WIDER IMPLICATION OF THE FINDINGS
Our findings warrant future studies designed to investigate the association between specific ART procedures and MZT, namely the potential risk of blastocyst transfer to increase MZT.
STUDY FUNDING/COMPETING INTEREST(S)
No external funding was used for this study. There are no conflicts of interest. |
| doi_str_mv | 10.1093/humrep/dew216 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1845823657</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1093/humrep/dew216</oup_id><sourcerecordid>1845823657</sourcerecordid><originalsourceid>FETCH-LOGICAL-c431t-3e2b294f9ed70988c1c33c9f899a878c8e3ec6867e2caccafadf105e0034ebc73</originalsourceid><addsrcrecordid>eNqFkEtLw0AURgdRbK0u3UqWbmLnkUwmKymtLygIUtfD9OZOO9JkYiah1F9vS6ouXd27OJwPDiHXjN4xmovxuisbrMcFbjmTJ2TIEkljLlJ6SoaUSxUzJtmAXITwQen-VfKcDHgmZcIZG5J05qPJ2yJExlqENmrXGLkKXIEVYORtVPrKf-1WvnUQtVtXVa5a3V-SM2s2Aa-Od0TeHx8W0-d4_vr0Mp3MY0gEa2OBfMnzxOZYZDRXChgIAblVeW5UpkChQJBKZsjBABhrCstoipSKBJeQiRG57b114z87DK0uXQDcbEyFvguaqSRVXMj0gMY9Co0PoUGr68aVptlpRvWhlO5L6b7Unr85qrtlicUv_ZPmb9t39T-ubwtkc8o</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1845823657</pqid></control><display><type>article</type><title>Do ARTs affect the incidence of monozygotic twinning?</title><source>Oxford University Press Journals</source><source>MEDLINE</source><source>Alma/SFX Local Collection</source><source>EZB Electronic Journals Library</source><creator>Mateizel, I. ; Santos-Ribeiro, S. ; Done, E. ; Van Landuyt, L. ; Van de Velde, H. ; Tournaye, H. ; Verheyen, G.</creator><creatorcontrib>Mateizel, I. ; Santos-Ribeiro, S. ; Done, E. ; Van Landuyt, L. ; Van de Velde, H. ; Tournaye, H. ; Verheyen, G.</creatorcontrib><description>STUDY QUESTION
Does the manipulation of gametes or embryos during ARTs increase the risk for monozygotic twinning (MZT)?
SUMMARY ANSWER
Frozen embryo transfer (ET) is associated with a lower MZT rate, while blastocyst culture is associated with an increased risk of monozygotic pregnancy.
WHAT IS KNOWN ALREADY
Monozygotic twins have a higher risk for perinatal complications. Although an increased incidence of monozygotic pregnancies after ART has been previously reported, data regarding the possible impact of different laboratory procedures are conflicting.
STUDY DESIGN, SIZE, DURATION
All clinical pregnancies after single ET carried out in our centre between 2004 and 2013 (n = 6096) were retrospectively analysed for the incidence of MZT. The effect of different laboratory procedures on the incidence of MZT was evaluated.
PARTICIPANTS/MATERIALS, SETTING, METHODS
The following ART risk factors were assessed: maternal age, type of ET (fresh versus frozen), zona pellucida (ZP) manipulation (specifically, ICSI, embryo biopsy and assisted hatching), use of donor oocytes, embryo stage at time of ET (cleavage, compaction, early or advanced blastocyst) and culture media.
MAIN RESULTS AND THE ROLE OF CHANCE
The overall MZT rate was 2.2% (136/6096). Frozen ET was associated with a significant reduction in MZT incidence (adjusted odds ratio (aOR) 0.48, 95% CI 0.29–0.80), while blastocyst transfer (early or advanced blastocyst) was associated with a significant increase in MZT risk (aOR 2.70, 95% CI 1.36–5.34; aOR 2.05, 95% CI 1.29–3.26, respectively). No significant differences were found between the MZT and singleton (non-MZT) groups regarding maternal age, the use of different ZP manipulation techniques, not type of culture media used.
LIMITATION, REASONS FOR CAUTION
This study is limited by its retrospective nature and the fact that monozygosity was not confirmed by genetic testing. Furthermore, since monozygotic pregnancy is a rare event, other ART parameters that may influence its incidence could not be assessed during our analysis.
WIDER IMPLICATION OF THE FINDINGS
Our findings warrant future studies designed to investigate the association between specific ART procedures and MZT, namely the potential risk of blastocyst transfer to increase MZT.
STUDY FUNDING/COMPETING INTEREST(S)
No external funding was used for this study. There are no conflicts of interest.</description><identifier>ISSN: 0268-1161</identifier><identifier>EISSN: 1460-2350</identifier><identifier>DOI: 10.1093/humrep/dew216</identifier><identifier>PMID: 27664211</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Adult ; Embryo Culture Techniques ; Female ; Humans ; Incidence ; Oocyte Donation ; Pregnancy ; Reproductive Techniques, Assisted ; Retrospective Studies ; Single Embryo Transfer ; Twinning, Monozygotic</subject><ispartof>Human reproduction (Oxford), 2016-11, Vol.31 (11), p.2435-2441</ispartof><rights>The Author 2016. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com 2016</rights><rights>The Author 2016. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c431t-3e2b294f9ed70988c1c33c9f899a878c8e3ec6867e2caccafadf105e0034ebc73</citedby><cites>FETCH-LOGICAL-c431t-3e2b294f9ed70988c1c33c9f899a878c8e3ec6867e2caccafadf105e0034ebc73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1578,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27664211$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mateizel, I.</creatorcontrib><creatorcontrib>Santos-Ribeiro, S.</creatorcontrib><creatorcontrib>Done, E.</creatorcontrib><creatorcontrib>Van Landuyt, L.</creatorcontrib><creatorcontrib>Van de Velde, H.</creatorcontrib><creatorcontrib>Tournaye, H.</creatorcontrib><creatorcontrib>Verheyen, G.</creatorcontrib><title>Do ARTs affect the incidence of monozygotic twinning?</title><title>Human reproduction (Oxford)</title><addtitle>Hum Reprod</addtitle><description>STUDY QUESTION
Does the manipulation of gametes or embryos during ARTs increase the risk for monozygotic twinning (MZT)?
SUMMARY ANSWER
Frozen embryo transfer (ET) is associated with a lower MZT rate, while blastocyst culture is associated with an increased risk of monozygotic pregnancy.
WHAT IS KNOWN ALREADY
Monozygotic twins have a higher risk for perinatal complications. Although an increased incidence of monozygotic pregnancies after ART has been previously reported, data regarding the possible impact of different laboratory procedures are conflicting.
STUDY DESIGN, SIZE, DURATION
All clinical pregnancies after single ET carried out in our centre between 2004 and 2013 (n = 6096) were retrospectively analysed for the incidence of MZT. The effect of different laboratory procedures on the incidence of MZT was evaluated.
PARTICIPANTS/MATERIALS, SETTING, METHODS
The following ART risk factors were assessed: maternal age, type of ET (fresh versus frozen), zona pellucida (ZP) manipulation (specifically, ICSI, embryo biopsy and assisted hatching), use of donor oocytes, embryo stage at time of ET (cleavage, compaction, early or advanced blastocyst) and culture media.
MAIN RESULTS AND THE ROLE OF CHANCE
The overall MZT rate was 2.2% (136/6096). Frozen ET was associated with a significant reduction in MZT incidence (adjusted odds ratio (aOR) 0.48, 95% CI 0.29–0.80), while blastocyst transfer (early or advanced blastocyst) was associated with a significant increase in MZT risk (aOR 2.70, 95% CI 1.36–5.34; aOR 2.05, 95% CI 1.29–3.26, respectively). No significant differences were found between the MZT and singleton (non-MZT) groups regarding maternal age, the use of different ZP manipulation techniques, not type of culture media used.
LIMITATION, REASONS FOR CAUTION
This study is limited by its retrospective nature and the fact that monozygosity was not confirmed by genetic testing. Furthermore, since monozygotic pregnancy is a rare event, other ART parameters that may influence its incidence could not be assessed during our analysis.
WIDER IMPLICATION OF THE FINDINGS
Our findings warrant future studies designed to investigate the association between specific ART procedures and MZT, namely the potential risk of blastocyst transfer to increase MZT.
STUDY FUNDING/COMPETING INTEREST(S)
No external funding was used for this study. There are no conflicts of interest.</description><subject>Adult</subject><subject>Embryo Culture Techniques</subject><subject>Female</subject><subject>Humans</subject><subject>Incidence</subject><subject>Oocyte Donation</subject><subject>Pregnancy</subject><subject>Reproductive Techniques, Assisted</subject><subject>Retrospective Studies</subject><subject>Single Embryo Transfer</subject><subject>Twinning, Monozygotic</subject><issn>0268-1161</issn><issn>1460-2350</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtLw0AURgdRbK0u3UqWbmLnkUwmKymtLygIUtfD9OZOO9JkYiah1F9vS6ouXd27OJwPDiHXjN4xmovxuisbrMcFbjmTJ2TIEkljLlJ6SoaUSxUzJtmAXITwQen-VfKcDHgmZcIZG5J05qPJ2yJExlqENmrXGLkKXIEVYORtVPrKf-1WvnUQtVtXVa5a3V-SM2s2Aa-Od0TeHx8W0-d4_vr0Mp3MY0gEa2OBfMnzxOZYZDRXChgIAblVeW5UpkChQJBKZsjBABhrCstoipSKBJeQiRG57b114z87DK0uXQDcbEyFvguaqSRVXMj0gMY9Co0PoUGr68aVptlpRvWhlO5L6b7Unr85qrtlicUv_ZPmb9t39T-ubwtkc8o</recordid><startdate>20161101</startdate><enddate>20161101</enddate><creator>Mateizel, I.</creator><creator>Santos-Ribeiro, S.</creator><creator>Done, E.</creator><creator>Van Landuyt, L.</creator><creator>Van de Velde, H.</creator><creator>Tournaye, H.</creator><creator>Verheyen, G.</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20161101</creationdate><title>Do ARTs affect the incidence of monozygotic twinning?</title><author>Mateizel, I. ; Santos-Ribeiro, S. ; Done, E. ; Van Landuyt, L. ; Van de Velde, H. ; Tournaye, H. ; Verheyen, G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c431t-3e2b294f9ed70988c1c33c9f899a878c8e3ec6867e2caccafadf105e0034ebc73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Embryo Culture Techniques</topic><topic>Female</topic><topic>Humans</topic><topic>Incidence</topic><topic>Oocyte Donation</topic><topic>Pregnancy</topic><topic>Reproductive Techniques, Assisted</topic><topic>Retrospective Studies</topic><topic>Single Embryo Transfer</topic><topic>Twinning, Monozygotic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mateizel, I.</creatorcontrib><creatorcontrib>Santos-Ribeiro, S.</creatorcontrib><creatorcontrib>Done, E.</creatorcontrib><creatorcontrib>Van Landuyt, L.</creatorcontrib><creatorcontrib>Van de Velde, H.</creatorcontrib><creatorcontrib>Tournaye, H.</creatorcontrib><creatorcontrib>Verheyen, G.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Human reproduction (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mateizel, I.</au><au>Santos-Ribeiro, S.</au><au>Done, E.</au><au>Van Landuyt, L.</au><au>Van de Velde, H.</au><au>Tournaye, H.</au><au>Verheyen, G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Do ARTs affect the incidence of monozygotic twinning?</atitle><jtitle>Human reproduction (Oxford)</jtitle><addtitle>Hum Reprod</addtitle><date>2016-11-01</date><risdate>2016</risdate><volume>31</volume><issue>11</issue><spage>2435</spage><epage>2441</epage><pages>2435-2441</pages><issn>0268-1161</issn><eissn>1460-2350</eissn><abstract>STUDY QUESTION
Does the manipulation of gametes or embryos during ARTs increase the risk for monozygotic twinning (MZT)?
SUMMARY ANSWER
Frozen embryo transfer (ET) is associated with a lower MZT rate, while blastocyst culture is associated with an increased risk of monozygotic pregnancy.
WHAT IS KNOWN ALREADY
Monozygotic twins have a higher risk for perinatal complications. Although an increased incidence of monozygotic pregnancies after ART has been previously reported, data regarding the possible impact of different laboratory procedures are conflicting.
STUDY DESIGN, SIZE, DURATION
All clinical pregnancies after single ET carried out in our centre between 2004 and 2013 (n = 6096) were retrospectively analysed for the incidence of MZT. The effect of different laboratory procedures on the incidence of MZT was evaluated.
PARTICIPANTS/MATERIALS, SETTING, METHODS
The following ART risk factors were assessed: maternal age, type of ET (fresh versus frozen), zona pellucida (ZP) manipulation (specifically, ICSI, embryo biopsy and assisted hatching), use of donor oocytes, embryo stage at time of ET (cleavage, compaction, early or advanced blastocyst) and culture media.
MAIN RESULTS AND THE ROLE OF CHANCE
The overall MZT rate was 2.2% (136/6096). Frozen ET was associated with a significant reduction in MZT incidence (adjusted odds ratio (aOR) 0.48, 95% CI 0.29–0.80), while blastocyst transfer (early or advanced blastocyst) was associated with a significant increase in MZT risk (aOR 2.70, 95% CI 1.36–5.34; aOR 2.05, 95% CI 1.29–3.26, respectively). No significant differences were found between the MZT and singleton (non-MZT) groups regarding maternal age, the use of different ZP manipulation techniques, not type of culture media used.
LIMITATION, REASONS FOR CAUTION
This study is limited by its retrospective nature and the fact that monozygosity was not confirmed by genetic testing. Furthermore, since monozygotic pregnancy is a rare event, other ART parameters that may influence its incidence could not be assessed during our analysis.
WIDER IMPLICATION OF THE FINDINGS
Our findings warrant future studies designed to investigate the association between specific ART procedures and MZT, namely the potential risk of blastocyst transfer to increase MZT.
STUDY FUNDING/COMPETING INTEREST(S)
No external funding was used for this study. There are no conflicts of interest.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>27664211</pmid><doi>10.1093/humrep/dew216</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Human reproduction (Oxford), 2016-11, Vol.31 (11), p.2435-2441 |
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| language | eng |
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| source | Oxford University Press Journals; MEDLINE; Alma/SFX Local Collection; EZB Electronic Journals Library |
| subjects | Adult Embryo Culture Techniques Female Humans Incidence Oocyte Donation Pregnancy Reproductive Techniques, Assisted Retrospective Studies Single Embryo Transfer Twinning, Monozygotic |
| title | Do ARTs affect the incidence of monozygotic twinning? |
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