Palladium-catalyzed Sonogashira coupling of amides: access to ynones via C-N bond cleavage

The first palladium-catalyzed Sonogashira coupling of amides has been developed, which proceeds via a selective cleavage of the N-acylsaccharin C-N bond. Notably, the new approach employs N-acylsaccharins as coupling partners to give ynones in good to excellent yield. This protocol can be efficientl...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2016-01, Vol.52 (81), p.12076-12079
Hauptverfasser:	Cui, Ming, Wu, Hongxiang, Jian, Junsheng, Wang, Hui, Liu, Chao, Daniel, Stelck, Zeng, Zhuo
Format:	Artikel
Sprache:	eng
Schlagworte:	Amides Arrays Bonding Catalysts Cleavage Coupling Palladium Synthesis (chemistry)
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creator	Cui, Ming Wu, Hongxiang Jian, Junsheng Wang, Hui Liu, Chao Daniel, Stelck Zeng, Zhuo
description	The first palladium-catalyzed Sonogashira coupling of amides has been developed, which proceeds via a selective cleavage of the N-acylsaccharin C-N bond. Notably, the new approach employs N-acylsaccharins as coupling partners to give ynones in good to excellent yield. This protocol can be efficiently utilized in the synthesis of a broad array of ynones under low catalyst loading and Cu-free conditions.
doi_str_mv	10.1039/c6cc06428k
format	Article
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subjects	Amides Arrays Bonding Catalysts Cleavage Coupling Palladium Synthesis (chemistry)
title	Palladium-catalyzed Sonogashira coupling of amides: access to ynones via C-N bond cleavage
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