Analgesia in clinically relevant rodent models of sepsis
Postoperative analgesia in rodent sepsis models has been considerably neglected in the past. However, intentions to model clinical practice, increasing awareness of animal ethics, efforts to apply the 3Rs (replacement, reduction, refinement), and stricter legislation argue for a change in this respe...
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| Veröffentlicht in: | Laboratory animals (London) 2016-12, Vol.50 (6), p.418-426 |
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| creator | Jeger, Victor Hauffe, Till Nicholls-Vuille, Flora Bettex, Dominique Rudiger, Alain |
| description | Postoperative analgesia in rodent sepsis models has been considerably neglected in the past. However, intentions to model clinical practice, increasing awareness of animal ethics, efforts to apply the 3Rs (replacement, reduction, refinement), and stricter legislation argue for a change in this respect. In this review, we describe different concepts of analgesia in rodent models of sepsis focusing on opioid agonists as well as non-opioid analgesics. Advantages and pitfalls in study design and side-effects are discussed. Score sheets should be used to adapt analgesia or to terminate experiments using humane endpoints. Further research is needed to differentiate behavioral changes caused by sepsis and pain or as a consequence of analgesia. Information on the efficacy of analgesia in sepsis models is scarce. Hence, studies are needed to identify the best ways to reduce suffering of research animals and thereby optimize the clinically relevant rodent models of sepsis. |
| doi_str_mv | 10.1177/0023677216675009 |
| format | Article |
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However, intentions to model clinical practice, increasing awareness of animal ethics, efforts to apply the 3Rs (replacement, reduction, refinement), and stricter legislation argue for a change in this respect. In this review, we describe different concepts of analgesia in rodent models of sepsis focusing on opioid agonists as well as non-opioid analgesics. Advantages and pitfalls in study design and side-effects are discussed. Score sheets should be used to adapt analgesia or to terminate experiments using humane endpoints. Further research is needed to differentiate behavioral changes caused by sepsis and pain or as a consequence of analgesia. Information on the efficacy of analgesia in sepsis models is scarce. Hence, studies are needed to identify the best ways to reduce suffering of research animals and thereby optimize the clinically relevant rodent models of sepsis.</description><subject>Analgesia - classification</subject><subject>Analgesia - methods</subject><subject>Analgesia - utilization</subject><subject>Analgesics - therapeutic use</subject><subject>Analgesics, Opioid - therapeutic use</subject><subject>Animals</subject><subject>Disease Models, Animal</subject><subject>Mice</subject><subject>Postoperative Care - methods</subject><subject>Rats</subject><subject>Research Design</subject><subject>Sepsis - prevention & control</subject><issn>0023-6772</issn><issn>1758-1117</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kDFPwzAQhS0EoqWwM6GMLAE7dux4rCoKSJVYYLYc51ylcpLia5D673HVwoDE9HT6vnvDI-SW0QfGlHqktOBSqYJJqUpK9RmZMlVWOUv0nEwPOD_wCblC3KSTiYpekkmhNNVMsymp5r0Na8DWZm2fudD2rbMh7LMIAb5sv8vi0ECKLkXAbPAZwhZbvCYX3gaEm1POyMfy6X3xkq_enl8X81XuOFe73HJZSgaCagXS11J5oRveCAkKbM2t95JZpwutBC2FlFXNPS28lM6KJnE-I_fH3m0cPkfAneladBCC7WEY0bBKlFVRlJQllR5VFwfECN5sY9vZuDeMmsNe5u9e6eXu1D7WHTS_Dz8DJSE_CmjXYDbDGNNe-H_hN8ZRcVU</recordid><startdate>201612</startdate><enddate>201612</enddate><creator>Jeger, Victor</creator><creator>Hauffe, Till</creator><creator>Nicholls-Vuille, Flora</creator><creator>Bettex, Dominique</creator><creator>Rudiger, Alain</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201612</creationdate><title>Analgesia in clinically relevant rodent models of sepsis</title><author>Jeger, Victor ; Hauffe, Till ; Nicholls-Vuille, Flora ; Bettex, Dominique ; Rudiger, Alain</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c337t-a36561e4097e6fb67f49d3d46e7eab3aff61ac92974054668b3f02f66ca4db3a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Analgesia - classification</topic><topic>Analgesia - methods</topic><topic>Analgesia - utilization</topic><topic>Analgesics - therapeutic use</topic><topic>Analgesics, Opioid - therapeutic use</topic><topic>Animals</topic><topic>Disease Models, Animal</topic><topic>Mice</topic><topic>Postoperative Care - methods</topic><topic>Rats</topic><topic>Research Design</topic><topic>Sepsis - prevention & control</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jeger, Victor</creatorcontrib><creatorcontrib>Hauffe, Till</creatorcontrib><creatorcontrib>Nicholls-Vuille, Flora</creatorcontrib><creatorcontrib>Bettex, Dominique</creatorcontrib><creatorcontrib>Rudiger, Alain</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Laboratory animals (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jeger, Victor</au><au>Hauffe, Till</au><au>Nicholls-Vuille, Flora</au><au>Bettex, Dominique</au><au>Rudiger, Alain</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Analgesia in clinically relevant rodent models of sepsis</atitle><jtitle>Laboratory animals (London)</jtitle><addtitle>Lab Anim</addtitle><date>2016-12</date><risdate>2016</risdate><volume>50</volume><issue>6</issue><spage>418</spage><epage>426</epage><pages>418-426</pages><issn>0023-6772</issn><eissn>1758-1117</eissn><abstract>Postoperative analgesia in rodent sepsis models has been considerably neglected in the past. However, intentions to model clinical practice, increasing awareness of animal ethics, efforts to apply the 3Rs (replacement, reduction, refinement), and stricter legislation argue for a change in this respect. In this review, we describe different concepts of analgesia in rodent models of sepsis focusing on opioid agonists as well as non-opioid analgesics. Advantages and pitfalls in study design and side-effects are discussed. Score sheets should be used to adapt analgesia or to terminate experiments using humane endpoints. Further research is needed to differentiate behavioral changes caused by sepsis and pain or as a consequence of analgesia. Information on the efficacy of analgesia in sepsis models is scarce. Hence, studies are needed to identify the best ways to reduce suffering of research animals and thereby optimize the clinically relevant rodent models of sepsis.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>27909191</pmid><doi>10.1177/0023677216675009</doi><tpages>9</tpages></addata></record> |
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| ispartof | Laboratory animals (London), 2016-12, Vol.50 (6), p.418-426 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; SAGE Complete A-Z List |
| subjects | Analgesia - classification Analgesia - methods Analgesia - utilization Analgesics - therapeutic use Analgesics, Opioid - therapeutic use Animals Disease Models, Animal Mice Postoperative Care - methods Rats Research Design Sepsis - prevention & control |
| title | Analgesia in clinically relevant rodent models of sepsis |
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