A Multicenter, Double-Blind, Placebo-Controlled Trial Comparing Piperacillin-Tazobactam with and without Amikacin as Empiric Therapy for Febrile Neutropenia

In a prospective, multicenter, double-blind, randomized clinical trial, we compared the efficacy of piperacillin-tazobactam (4.5 g 3 times daily intravenously) plus placebo versus piperacillin-tazobactam plus amikacin (7.5 mg/kg twice daily intravenously) for the treatment of 760 febrile, adult pati...

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Veröffentlicht in:	Clinical infectious diseases 2001-10, Vol.33 (8), p.1295-1301
Hauptverfasser:	Del Favero, Albano, Menichetti, Francesco, Martino, Pietro, Bucaneve, Giampaolo, Micozzi, Alessandra, Gentile, Giuseppe, Furno, Paolo, Russo, Domenico, D'Antonio, Domenico, Ricci, Paolo, Martino, Bruno, Mandelli, Franco
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Amikacin - therapeutic use Anti-Bacterial Agents - therapeutic use Antibacterial agents Antibiotics Antibiotics. Antiinfectious agents. Antiparasitic agents Bacteremia Bacterial Infections - drug therapy Bacterial Infections - physiopathology Biological and medical sciences Double-Blind Method Drug Therapy, Combination - therapeutic use Experimentation Female Fever Fever - etiology Humans Infections Major Articles Male Medical sciences Microorganisms Middle Aged Neutropenia Neutropenia - chemically induced Neutropenia - complications Oncology Penicillanic Acid - analogs & derivatives Penicillanic Acid - therapeutic use Pharmacology. Drug treatments Piperacillin - therapeutic use Prospective Studies Response rates Staphylococcus Treatment Outcome
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