Cephalotanins A-D, Four Norditerpenoids Represent Three Highly Rigid Carbon Skeletons from Cephalotaxus sinensis

Four polycyclic norditerpenoids, cephalotanins A–D (1–4) representing three unprecedented carbon skeletons with highly rigid ring systems, were isolated from Cephalotaxus sinensis and structurally characterized by a combination of various methods. Compounds 1 and 2 are new skeletal norditerpenoid tr...

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Veröffentlicht in:	Chemistry : a European journal 2016-10, Vol.22 (41), p.14648-14654
Hauptverfasser:	Xu, Jin-Biao, Fan, Yao-Yue, Gan, Li-She, Zhou, Yu-Bo, Li, Jia, Yue, Jian-Min
Format:	Artikel
Sprache:	eng
Schlagworte:	biosynthetic pathways Carbon Carbon - chemistry cephalotanins Cephalotaxus - chemistry cephalotaxus norditerpenoid Chemistry Diterpenes - chemistry Diterpenes - isolation & purification Diterpenes - pharmacology HEK293 Cells Humans Inhibition Molecular Docking Simulation Molecular Structure Natural products NF-kappa B - antagonists & inhibitors nf-κb inhibition Pathways Plant Extracts - chemistry Plant Leaves - chemistry Precursors structural elucidation Structure-Activity Relationship
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