Resolving Conflicting Predictions from Multimapping Reads

The first step in the analysis of data produced by ultra-high-throughput next-generation sequencing technology is to map short sequence "reads" to a reference genome, if available. Sequencing errors, repeat regions, and polymorphisms may lead a read to align to multiple locations in the ge...

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Veröffentlicht in:	Journal of computational biology 2016-03, Vol.23 (3), p.203-217
Hauptverfasser:	Canzar, Stefan, Elbassioni, Khaled, Jones, Mitchell, Mestre, Julián
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Alignment Biology Contig Mapping - methods Contig Mapping - standards Deletion Gene sequencing Genome, Human Genomes Human Genome Project Humans Mapping Mathematical models Polymorphism, Genetic Utilities
Online-Zugang:	Volltext
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