Evaluation of route-to-route extrapolation factors based on assessment of repeated dose toxicity studies compiled in the database RepDose registered

The majority of repeated dose toxicity studies are available for the oral route. For risk assessment, however, data are needed from the relevant exposure route, i.e. inhalation or dermal. Instead of conducting additional animal studies, route-to-route (R2R) extrapolation may be performed. To explore...

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Veröffentlicht in:	Toxicology letters 2016-11, Vol.261, p.32-40
Hauptverfasser:	Schroder, K, Escher, SE, Hoffmann-Dorr, S, Kuehne, R, Simetska, N, Mangelsdorf, I
Format:	Artikel
Sprache:	eng
Schlagworte:	Confidence intervals Exposure Extrapolation Inhalation Toxicity Toxicology Uncertainty
Online-Zugang:	Volltext
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