On the possibility of ephedrine detection: time-resolved fluorescence resonance energy transfer (FRET)-based approach
Ephedrine is one of the main precursor compounds used in the illegal production of amphetamines and related drugs. Actually, conventional analytical methods such as high-performance liquid chromatography (HPLC), capillary electrophoresis (CE), and gas chromatography–mass spectrometry (GC–MS) are use...
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| Veröffentlicht in: | Analytical and bioanalytical chemistry 2016-09, Vol.408 (23), p.6329-6336 |
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| creator | Varriale, Antonio Marzullo, Vincenzo Manuel Di Giovanni, Stefano Scala, Andrea Capo, Alessandro Majoli, Adelia Pennacchio, Angela Staiano, Maria D’Auria, Sabato |
| description | Ephedrine is one of the main precursor compounds used in the illegal production of amphetamines and related drugs. Actually, conventional analytical methods such as high-performance liquid chromatography (HPLC), capillary electrophoresis (CE), and gas chromatography–mass spectrometry (GC–MS) are used for the detection of ephedrine; sadly, these methods require qualified personnel and are time-consuming and expensive. In order to overcome these problems, in recent years, different methods have been developed based on the surface plasmon resonance (SPR) and electrochemical method. In this work, we present a simple, rapid, and effective method to detect the presence of ephedrine in solution, based on competitive fluorescence resonance energy transfer (FRET) assay. The antibody anti-ephedrine and ephedrine derivative were produced and labeled respectively, with two different fluorescent probes (donor and acceptor). The change in FRET signal intensity between donor and acceptor ephedrine compounds gives the possibility of detecting ephedrine traces of at least 0.81 ± 0.04 ppm (LOD).
Graphical abstract
A new Time-resolved Fluorescence Resonance Energy Transfer (FRET) assay for ephedrine detection |
| doi_str_mv | 10.1007/s00216-016-9738-y |
| format | Article |
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Graphical abstract
A new Time-resolved Fluorescence Resonance Energy Transfer (FRET) assay for ephedrine detection</description><identifier>ISSN: 1618-2642</identifier><identifier>EISSN: 1618-2650</identifier><identifier>DOI: 10.1007/s00216-016-9738-y</identifier><identifier>PMID: 27395357</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Amphetamines ; Analytical Chemistry ; Animals ; Antibodies ; Biochemistry ; Capillary electrophoresis ; Central Nervous System Stimulants - analysis ; Characterization and Evaluation of Materials ; Chemical properties ; Chemistry ; Chemistry and Materials Science ; Chromatography ; Electrochemistry ; Energy ; Energy transfer ; Enzymes ; Ephedra sinica - chemistry ; Ephedrine ; Ephedrine - analysis ; Fluorescence ; Fluorescence Resonance Energy Transfer - methods ; Fluorescence spectroscopy ; Fluorescent Dyes - chemistry ; Food Science ; Fretting ; Gas chromatography ; High performance liquid chromatography ; Identification and classification ; Immunoassay - methods ; Immunoglobulin G - chemistry ; Laboratories ; Laboratory Medicine ; Limit of Detection ; Liquid chromatography ; Mass spectrometry ; Mathematical analysis ; Methods ; Monitoring/Environmental Analysis ; Quantum dots ; Rabbits ; Research Paper ; Resonance</subject><ispartof>Analytical and bioanalytical chemistry, 2016-09, Vol.408 (23), p.6329-6336</ispartof><rights>Springer-Verlag Berlin Heidelberg 2016</rights><rights>COPYRIGHT 2016 Springer</rights><rights>Analytical and Bioanalytical Chemistry is a copyright of Springer, 2016.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c542t-c29cafd71fe655886d0866f044cee8f75942cbd9f05cf880d9f2e431806e50e63</citedby><cites>FETCH-LOGICAL-c542t-c29cafd71fe655886d0866f044cee8f75942cbd9f05cf880d9f2e431806e50e63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00216-016-9738-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00216-016-9738-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27395357$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Varriale, Antonio</creatorcontrib><creatorcontrib>Marzullo, Vincenzo Manuel</creatorcontrib><creatorcontrib>Di Giovanni, Stefano</creatorcontrib><creatorcontrib>Scala, Andrea</creatorcontrib><creatorcontrib>Capo, Alessandro</creatorcontrib><creatorcontrib>Majoli, Adelia</creatorcontrib><creatorcontrib>Pennacchio, Angela</creatorcontrib><creatorcontrib>Staiano, Maria</creatorcontrib><creatorcontrib>D’Auria, Sabato</creatorcontrib><title>On the possibility of ephedrine detection: time-resolved fluorescence resonance energy transfer (FRET)-based approach</title><title>Analytical and bioanalytical chemistry</title><addtitle>Anal Bioanal Chem</addtitle><addtitle>Anal Bioanal Chem</addtitle><description>Ephedrine is one of the main precursor compounds used in the illegal production of amphetamines and related drugs. Actually, conventional analytical methods such as high-performance liquid chromatography (HPLC), capillary electrophoresis (CE), and gas chromatography–mass spectrometry (GC–MS) are used for the detection of ephedrine; sadly, these methods require qualified personnel and are time-consuming and expensive. In order to overcome these problems, in recent years, different methods have been developed based on the surface plasmon resonance (SPR) and electrochemical method. In this work, we present a simple, rapid, and effective method to detect the presence of ephedrine in solution, based on competitive fluorescence resonance energy transfer (FRET) assay. The antibody anti-ephedrine and ephedrine derivative were produced and labeled respectively, with two different fluorescent probes (donor and acceptor). The change in FRET signal intensity between donor and acceptor ephedrine compounds gives the possibility of detecting ephedrine traces of at least 0.81 ± 0.04 ppm (LOD).
Graphical abstract
A new Time-resolved Fluorescence Resonance Energy Transfer (FRET) assay for ephedrine detection</description><subject>Amphetamines</subject><subject>Analytical Chemistry</subject><subject>Animals</subject><subject>Antibodies</subject><subject>Biochemistry</subject><subject>Capillary electrophoresis</subject><subject>Central Nervous System Stimulants - analysis</subject><subject>Characterization and Evaluation of Materials</subject><subject>Chemical properties</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Chromatography</subject><subject>Electrochemistry</subject><subject>Energy</subject><subject>Energy transfer</subject><subject>Enzymes</subject><subject>Ephedra sinica - chemistry</subject><subject>Ephedrine</subject><subject>Ephedrine - analysis</subject><subject>Fluorescence</subject><subject>Fluorescence Resonance Energy Transfer - methods</subject><subject>Fluorescence spectroscopy</subject><subject>Fluorescent Dyes - chemistry</subject><subject>Food Science</subject><subject>Fretting</subject><subject>Gas chromatography</subject><subject>High performance liquid chromatography</subject><subject>Identification and classification</subject><subject>Immunoassay - methods</subject><subject>Immunoglobulin G - chemistry</subject><subject>Laboratories</subject><subject>Laboratory Medicine</subject><subject>Limit of Detection</subject><subject>Liquid chromatography</subject><subject>Mass spectrometry</subject><subject>Mathematical analysis</subject><subject>Methods</subject><subject>Monitoring/Environmental Analysis</subject><subject>Quantum dots</subject><subject>Rabbits</subject><subject>Research 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the possibility of ephedrine detection: time-resolved fluorescence resonance energy transfer (FRET)-based approach</title><author>Varriale, Antonio ; Marzullo, Vincenzo Manuel ; Di Giovanni, Stefano ; Scala, Andrea ; Capo, Alessandro ; Majoli, Adelia ; Pennacchio, Angela ; Staiano, Maria ; D’Auria, Sabato</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c542t-c29cafd71fe655886d0866f044cee8f75942cbd9f05cf880d9f2e431806e50e63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Amphetamines</topic><topic>Analytical Chemistry</topic><topic>Animals</topic><topic>Antibodies</topic><topic>Biochemistry</topic><topic>Capillary electrophoresis</topic><topic>Central Nervous System Stimulants - analysis</topic><topic>Characterization and Evaluation of Materials</topic><topic>Chemical properties</topic><topic>Chemistry</topic><topic>Chemistry and Materials 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Actually, conventional analytical methods such as high-performance liquid chromatography (HPLC), capillary electrophoresis (CE), and gas chromatography–mass spectrometry (GC–MS) are used for the detection of ephedrine; sadly, these methods require qualified personnel and are time-consuming and expensive. In order to overcome these problems, in recent years, different methods have been developed based on the surface plasmon resonance (SPR) and electrochemical method. In this work, we present a simple, rapid, and effective method to detect the presence of ephedrine in solution, based on competitive fluorescence resonance energy transfer (FRET) assay. The antibody anti-ephedrine and ephedrine derivative were produced and labeled respectively, with two different fluorescent probes (donor and acceptor). The change in FRET signal intensity between donor and acceptor ephedrine compounds gives the possibility of detecting ephedrine traces of at least 0.81 ± 0.04 ppm (LOD).
Graphical abstract
A new Time-resolved Fluorescence Resonance Energy Transfer (FRET) assay for ephedrine detection</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>27395357</pmid><doi>10.1007/s00216-016-9738-y</doi><tpages>8</tpages></addata></record> |
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| subjects | Amphetamines Analytical Chemistry Animals Antibodies Biochemistry Capillary electrophoresis Central Nervous System Stimulants - analysis Characterization and Evaluation of Materials Chemical properties Chemistry Chemistry and Materials Science Chromatography Electrochemistry Energy Energy transfer Enzymes Ephedra sinica - chemistry Ephedrine Ephedrine - analysis Fluorescence Fluorescence Resonance Energy Transfer - methods Fluorescence spectroscopy Fluorescent Dyes - chemistry Food Science Fretting Gas chromatography High performance liquid chromatography Identification and classification Immunoassay - methods Immunoglobulin G - chemistry Laboratories Laboratory Medicine Limit of Detection Liquid chromatography Mass spectrometry Mathematical analysis Methods Monitoring/Environmental Analysis Quantum dots Rabbits Research Paper Resonance |
| title | On the possibility of ephedrine detection: time-resolved fluorescence resonance energy transfer (FRET)-based approach |
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