Radical trideuteromethylation with deuterated dimethyl sulfoxide in the synthesis of heterocycles and labelled building blocks
The potential of deuterated pharmaceuticals is being widely demonstrated. Here we describe the first trideuteromethylation under radical reaction conditions using deuterated dimethyl sulfoxide as a reagent for the synthesis of labelled heterocycles and trideuteromethylated compounds. A broad scope o...
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| Veröffentlicht in: | Chemical communications (Cambridge, England) England), 2016-01, Vol.52 (84), p.12486-12489 |
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| container_issue | 84 |
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| container_title | Chemical communications (Cambridge, England) |
| container_volume | 52 |
| creator | Caporaso, Roberta Manna, Srimanta Zinken, Sarah Kochnev, Alexander R Lukyanenko, Evgeny R Kurkin, Alexander V Antonchick, Andrey P |
| description | The potential of deuterated pharmaceuticals is being widely demonstrated. Here we describe the first trideuteromethylation under radical reaction conditions using deuterated dimethyl sulfoxide as a reagent for the synthesis of labelled heterocycles and trideuteromethylated compounds. A broad scope of the developed method for the synthesis of various scaffolds was demonstrated. |
| doi_str_mv | 10.1039/c6cc07196a |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 1359-7345 |
| ispartof | Chemical communications (Cambridge, England), 2016-01, Vol.52 (84), p.12486-12489 |
| issn | 1359-7345 1364-548X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1845799414 |
| source | Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Deuteration Dimethyl sulfoxide Pharmaceuticals Radicals Reagents Scaffolds Synthesis Synthesis (chemistry) |
| title | Radical trideuteromethylation with deuterated dimethyl sulfoxide in the synthesis of heterocycles and labelled building blocks |
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