Radical trideuteromethylation with deuterated dimethyl sulfoxide in the synthesis of heterocycles and labelled building blocks

Radical trideuteromethylation with deuterated dimethyl sulfoxide in the synthesis of heterocycles and labelled building blocks

The potential of deuterated pharmaceuticals is being widely demonstrated. Here we describe the first trideuteromethylation under radical reaction conditions using deuterated dimethyl sulfoxide as a reagent for the synthesis of labelled heterocycles and trideuteromethylated compounds. A broad scope o...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2016-01, Vol.52 (84), p.12486-12489
Hauptverfasser: Caporaso, Roberta, Manna, Srimanta, Zinken, Sarah, Kochnev, Alexander R, Lukyanenko, Evgeny R, Kurkin, Alexander V, Antonchick, Andrey P
Format: Artikel
Sprache:eng
Schlagworte:
Deuteration
Dimethyl sulfoxide
Pharmaceuticals
Radicals
Reagents
Scaffolds
Synthesis
Synthesis (chemistry)
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Zusammenfassung:The potential of deuterated pharmaceuticals is being widely demonstrated. Here we describe the first trideuteromethylation under radical reaction conditions using deuterated dimethyl sulfoxide as a reagent for the synthesis of labelled heterocycles and trideuteromethylated compounds. A broad scope of the developed method for the synthesis of various scaffolds was demonstrated.
ISSN:1359-7345
1364-548X
DOI:10.1039/c6cc07196a