Regio- and stereoselective synthesis of novel spiropyrrolidines through 1,3-dipolar cycloaddition reactions of azomethine ylides and 2-styrylquinazolin-4(3H)-ones
Efficient regio- and stereoselective synthesis of novel of spiropyrrolidines was achieved through 1,3-dipolar cycloaddition reaction of 2-styrylquinazolin-4(3 H )-ones with azomethine ylides generated in situ from decarboxylative coupling of l -proline and isatin. The present approach offers the adv...
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| Veröffentlicht in: | RSC advances 2014-01, Vol.4 (61), p.32303-32311 |
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| container_title | RSC advances |
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| creator | Maurya, Ram Awatar Nayak, Ranjita Reddy, Chada Narsimha Kapure, Jeevak Sopanrao Nanubolu, Jagadeesh Babu Singarapu, Kiran Kumar Ajitha, M. kamal, Ahmed |
| description | Efficient regio- and stereoselective synthesis of novel of spiropyrrolidines was achieved through 1,3-dipolar cycloaddition reaction of 2-styrylquinazolin-4(3
H
)-ones with azomethine ylides generated
in situ
from decarboxylative coupling of
l
-proline and isatin. The present approach offers the advantages of a clean and simple methodology, high atom economy, short reaction time, wide substrate scope, and a high yielding protocol for spiropyrrolidines. |
| doi_str_mv | 10.1039/C4RA03508A |
| format | Article |
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H
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in situ
from decarboxylative coupling of
l
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H
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in situ
from decarboxylative coupling of
l
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H
)-ones with azomethine ylides generated
in situ
from decarboxylative coupling of
l
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| language | eng |
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| source | Royal Society Of Chemistry Journals 2008- |
| subjects | Cleaning Coupling Cycloaddition Economics Methodology Reaction time Substrates Synthesis (chemistry) |
| title | Regio- and stereoselective synthesis of novel spiropyrrolidines through 1,3-dipolar cycloaddition reactions of azomethine ylides and 2-styrylquinazolin-4(3H)-ones |
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