SAR studies of 3,14,19-derivatives of andrographolide on anti-proliferative activity to cancer cells and toxicity to zebrafish: an in vitro and in vivo study

Andrographolide is bestowed with an interesting pharmacophore and has attracted numerous studies on the design and synthesis of andrographolide derivatives. In this study, a small library of 3,14,19-modified derivatives of andrographolide were synthesized and tested for their in vitro inhibitory act...

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Veröffentlicht in:	RSC advances 2015-01, Vol.5 (29), p.22510-22526
Hauptverfasser:	Peng, Yuran, Li, Jingjing, Sun, Yicheng, Chan, Judy Yuet-Wa, Sheng, Dekuan, Wang, Kun, Wei, Ping, Ouyang, Pingkai, Wang, Decai, Lee, Simon Ming Yuen, Zhou, Guo-Chun
Format:	Artikel
Sprache:	eng
Schlagworte:	Cancer Danio rerio Derivatives Embryos Freshwater Libraries Pharmacology Synthesis Toxicity Zebrafish
Online-Zugang:	Volltext
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